DXO and DXM cross-tolerance

[Hyperspaced]

Hey everybody.

This question may sounds stupid, but did Dextromethorphan (DXM) and Dextrorphan (DXO) have a cross-tolerance?

I take DXM for 6 years now and the tolerance got up so high, that all the positive effects are gone.
I know that they 2 have different effects, but i can imagine that overall they still are quiet similiar 2 each other, arent they? So can I take DXO instead of DXM or wouldnt it change anything?

Thx for your help and greetz from germany

 

[viridarius]

As far as i know DXO is impossible to get really but your question is about tolerance so le me answer you. First off, your going to have cross tolerance between any two drugs that are in the same class. DXO and DXM are both disossitives so yes there will be cross tolerance between these to drugs. Second, DXO is produced when your body breaks down DXM. Part of the effects felt are from DXO, so along with the cross tolerance you also already have a tolerance to DXO itself. Ive heard people say that more DXO is produced when you take DXM polistirex over how much is produced when you take HBr. I don't know how accurate this is. If its true then if you usually take poli then you'll have a higher DXO tolerence then most DXM users.

 

[《Plasticity》]

You don't develop tolerance to any particular substance, but downregulation to the receptors responsible for a drugs effects. Although i've seen anecdote reporting that complete tolerance doesn't cross over between all dissociatives, likely due to the fact that other receptors contribute to the effects each drug, there is without a doubt always some degree of tolerance due to the fact that the main effects responisble for a dissociative are attributed through NMDA antagonism.

While DXM is a "dirty" drug (hits quit a few receptors), just about the only real differences between it and DXM as far as MOA goes is that DXO lacks SRI activity. In other words, expect near complete cross-tolerance. How do you plan on coming by pure DXO anyways?

 

[Hyperspaced]

Thanks 4 your answers. I dont think that long how he come on DXO. First he just wanna know if it would work to "change" the drugs, but as u both said it wouldnt change anything so thanks for your replies

Ketamin and MXE are also cross-tolerant to DXM, arent they? Both seem like good alternatives or?

Are there other similar drugs like DXM, that would work as an antidepressant and also give u some nice highs, without getting a tolerance that quick?

 

[《Plasticity》]

Yes, DXM, ketamine, and MXE are all cross-tolerant. However that doesn't mean there is no benefits to making a switch from DXM. The thing is that you can push the latter two to a higher level due to the fact that ingestion is so much easier and ketamine and MXE are easier on the body. Both MXE and ketamine are fantastic anti-depressants, so they should be a suitable alternative. MXE is also has serotonin re-uptake inhibitor activity like SSRI anti-depressants. Just curious, why do you ask? Have you reached a point where DXM isn't cutting it anymore? What's your dose?

Just so you know the term "SWIM" isn't allowed on bluelight, no big deal but it offers no protection and can really complicate posts when more than 1 person is involved therefor it's against the rules.

 

[Hyperspaced]

Ah ok i wont use SWIM anymore

I take DXM for 6 years now.
First 2 years: 2 times a week á 510 mg DXM-HBr
Second 2 years: 3 times a week á 400 mg DXM-HBr
5th year. 4 times a week á 350 mg DXM-HBr
Last year: Alot more, i lost control in the end i didnt had any positive effects from it so i pushed it with alcohol what in
the first month worked pretty well, but after that i fall down and went to the rehab...

What do u mean with ingestion is easier? So u recommend to first give MXE a try?

 

[《Plasticity》]

What I meant was that it's easier to snort a small line of ketamine, or eat/snort/sublingual (whatever method you wanna use) MXE than chug a bunch of syrup or eat a ton of robo gels and you won't get nearly as many gastrointestinal side-effects. I'm assuming your not using synthetic DXM powder?

 

[Hyperspaced]

In germany DXM is free availible in apothecerys as a cough blocker so you just have to eat 15 capsules, what isnt a big deal, i think.