Opioids DXM and Opiates question

[Anthrogirl]

I have a question for you guys. I hope i am posting in the right place. I am a chronic pain patient and I am also an ex opiate addict. As strange as this may seem I have been able to control my usage of opiates to only two to three days a week. The reason being is that I now get migraines and the opiates make them worse so I don't want to abuse them. I also try to keep my tolerance down by taking them only two to three times a week. The problem is my pain has gotten worse lately and I have had to take increasing amounts (although still only 3 times a week) and my tolerance has been getting worse and worse but I don't want to raise my narcotics even though my doc is willing. So I tried taking DXM (long acting) 60 mg twice a day starting Thursday night to try to reduce my tolerance.
About an hour ago I got a headache so I took two fioricet with Codiene that are prescribed to me for tension headaches. I am sitting here high as hell!! How did the DXM tolerance reduction effects kick in this quick? Is this normal? Does anyone know? I normally never feel anything from two Fioricet! I am now worried about taking my oxycodone or morphine. How will I know how much to take? I don't want to OD!

 

[Znegative]

Well, DXM lowers tolerance but it also acts as a potentiator for opiates. Not to mention that it also works similarly with barbiturates I believe. I would just avoid taking the. Stronger pain meds for the day if you can or take much lower dosages.

 

[laCster]

NMDA antagonism works best for lowering tolerance if taken 3-5 hrs before. I really like DXM and I like to mix DXM with bupre. However, I can down 590mg in a day and still be functional lol

 

[Anthrogirl]

Thanks for the replies! Next time my pain acts up I'm going to play it really safe and only take a 1/4 of my regular oxy or morphine dose (that's about as small as I can cut them). I just didn't expect the DXM to work so well or so fast at reducing tolerance.

 

[shimazu]

uhh DXM "reduces" tolerance?

I thought it was just a potentiator I didnt know anything could reduce a tolerance except time?

 

[laCster]

NMDA antagonists stop the onset of tolerance, and might even reduce tolerance... IDK about reducing tolerance, but it definitely kind of resets the tolerance. i found dosing the nmda-antagonist such as mxe of DXM 3-5 hrs before gave me the most noticeable "Reset" of tolerance.. like my tolerance wont drop, but lets say i got high off of 45mg oxy IR the past two days. usually, it would take 60mgs on the third day to feel "high" but 45mgs had me feeling good. if i took DXM 3-5hrs before hand (150-200mgs) and then took 45mgs on the third day, id be high as fuck! just as high, if not higher than two days before.

NMDA-antagonism reducing tolerance is all over the internet and all over bluelight. try typing "nmda-antagonist; tolerance bluelight" in google and you will get some good hits.

here ill go ahead and search for you...
http://www.bluelight.ru/vb/threads/...lection-of-the-evidence-and-anecdotal-reports

^ this is the megathread in ADD

 

[shimazu]

but is it really reducing your tolerance or just potentiating the dose you are about to take?

Six in one half dozen the other I guess but its kind of a misleading statement

 

[laCster]

^ idk about completely reducing, but it definitely stops tolerance from growing AND if you take the DXM at the same time or prior to dosing, the dextromehtorphan will potentiate (being a 2d6 and 3a4 substrate), and synergize with your opiate of choice

DXM is definitely worth a shot, and i can buy pure DXM syrup (~500mgs) for less than a pack of cigs. i am biased towards DXM thought as i get really good effects from it. a nice buzz, energy, and it goes really well with opiates!!