Ok so ive been taking Fluoxetine 20mg for 10 days now. A week at 20mg a day and the past 3 days 40mg a day im trying to dxm trip ive been doing it for years built my tolerance up so i have to take 3bottles of Robo (60pills). zzz sucks... anyways im wondering when its ok to take it last time i took my Fluoxetine was about 24hrs ago maybe a little longer aint tryin to get serotonin syndrome thx for your answers
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OD Moderators: Keif’ Richards | negrogesic
Misc DXM and Fluoxetine help plz...
- Thread starter DTG420
- Start date
icameasarat
Greenlighter
- Joined
- Sep 1, 2013
- Messages
- 20
20 MG is a pretty low dosage and 40 is pretty average. Flouxotine stays in your system for 10 days after your last dose (but the amount decreases each day of course)
ErgicMergic
Bluelighter
I've been on 90-120mg DXM extended release daily for about 1.5 years for therapeutic NMDA antagonism, and due to the Serotonin Syndrome scare, it took me a very long time to taper from 0 to 2.5 to 5mg to 7.5mg to 10mg Prozac once daily, which I've been on for about 5 months. A lot of doctors will say that a dose as low as 10mg of Prozac is almost a placebo as an anxiolytic, and they're probably right, but combined with the DXM, it has very powerful 5-HT (serotonin) reuptake inhibition synergy.
Here's the problem: Prozac is one of the longest acting pharmaceuticals out there, which is why you will feel no withdrawal if you miss less than 4-5 days of dosing, as the half-life for fluoxetine and norfluoxetine are ridiculously long, so don't think you can skip a few days of Prozac then trip of DXM. It will literally take 3 weeks without Prozac for the active metabolites to be significantly reduced to low enough levels where the risk of SS when mixing with DXM becomes a non-issue.
If you've been on Prozac for more than a couple of weeks, I wouldn't recommend it at all. If you're dead-set on tripping off an NMDA antagonist, try some Methoxetamine or pure (vial) Ketamine instead, as they have no appreciable 5-HT activity.
Here's the problem: Prozac is one of the longest acting pharmaceuticals out there, which is why you will feel no withdrawal if you miss less than 4-5 days of dosing, as the half-life for fluoxetine and norfluoxetine are ridiculously long, so don't think you can skip a few days of Prozac then trip of DXM. It will literally take 3 weeks without Prozac for the active metabolites to be significantly reduced to low enough levels where the risk of SS when mixing with DXM becomes a non-issue.
If you've been on Prozac for more than a couple of weeks, I wouldn't recommend it at all. If you're dead-set on tripping off an NMDA antagonist, try some Methoxetamine or pure (vial) Ketamine instead, as they have no appreciable 5-HT activity.
sekio
Bluelight Crew
2 weeks is the ideal "washout". DXM combined with antidepressants is a recipe for a very uncomfortable trip (serotonin syndrome and/or hypertensive crisis)