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Drugs that have caloric value

SpiralusSancti

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Beside booze what are some other that fit description? Even most other active alcohols don’t as far as I know. Is that due to some kind of booze-man co-evolution? Or is it easy enough to create other drug/foods? Design at least.

Ether has some caloric value too, due to being partly metablized to, ofc, ethanol.

When there’s any speak about ethanol alternatives, like alternative viable to really replace alcohol world wide I think all is cheap talk until two things ain’t realized. First being it can be produced by anyone by no more complex procedure but fermentation (or whatever bio-reaction) and distillation (or whatever easy to master extraction). Second thing I’m not sure how important but I suspect that it would need to be realized is that it’s like booze also a food. In times of famine and at some point in the future having drug that has caloric value is more important than it seems to people in the west. Having hundreds of liters of booze during famine did made lives in many nations in many points of history a lot easier. Would be cool if booze had b12 added to it as some propose to significantly cut down it’s damage. Beers with b vitamins and minerals actually don’t make a such a bad addition to a meal or even “a snack”. Same goes for a bit of some other quality drinks.

Back to the topic, I think caloric value of ethanol must have to do at least something to do with how appealing is it to most humans. If people get addicted do certain foods, and they do, getting addicted to a drug-food, and also enjoying it more than non-psychoactive foods seems perfectly logical. Things going other way too also seems pretty logical and I have a feeling that if that could be done, hypothetical 0 calories ethanol drinks would be chosen by less people than normal ethanol drinks. If test would be made so that drinks of similar taste, but some with 0 calorie ethanol and some with normal ethanol would be offered pretty soon most would chose ones with calories. Both cuz people evolved to seek caloric stuff (and same giving us a sort of pleasure) and cuz caloric ethanol likely has better effects and adds energetic component to high and makes more room before burn-out.

So what are some other drugs that have caloric value? I assume skillfull chemist could play around and create something like gluco-amphetamine of a sort so when it’s consumed it’s separated into some sugar and some amphetamine. But what would be really interesting is some molecule that is active by itself but also has caloric value. I feel that’ll be a property of a true alcohol replacement and not just potential alternative with similarish effects. I’m sure that molecule that is less similar in effects to alcohol than some stuff already in existence but will also have caloric value would more likely “cheat” the brain into thinking – hey, this is some great food-like drug and drug like food. And that being active compound itself and not mixture it’s put in could make a difference.

Another thing, is it possible to consume some enzymes and make some other drugs a food too? And what are best targets for modifying human DNA to be able to use them like food too? I’m pretty sure that can’t be done with GHB like drugs, but being able to metabolize such drug as a food source would automatically make it harder to OD on it. Maybe with enough use of some great drug we’ll evolve spontaneously to digest it like a food after a few million years of use.
 
Humans, and all animals that eat plants, have evolved alongside ethanol for many millions if not a billion years. Ever since fungus started feeding off sugars produced by plants.

It's probably why our bodies are relatively efficient at metabolizing it even though it's toxic.

Most animals have a similar reaction to it as humans (drunkenness), which may point to how far back in evolution animals started to evolve to handle it.

I wonder though, do other drugs not have calories, they just don't report them?

I believe the way they calculate the calorie content of food is they sort of light it on fire and calculate how much energy it releases. Wouldn't drugs also do that?

Maybe the reason ethanol has so many calories is because you're consuming so damn much of it when you drink. A single 5% abv beer has over 15g of ethanol in it. There's no other drug out there where a typical dose is in the range of an ounce or multiple ounces.

Would be cool if booze had b12 added to it as some propose to significantly cut down it’s damage.
That's actually an interesting idea. Beer could probably be made more nutritious. Although, maybe if they did it's illegal to advertise a beer as being "healthy", lol. At the very least they should add thiamine (B1).

There is kombucha or whatever it's called, fermented mushroom brew with ethanol in it, sold as a health drink. In the US it must not contain more than 0.5% abv or something

Another thing, is it possible to consume some enzymes and make some other drugs a food too? And what are best targets for modifying human DNA to be able to use them like food too? I’m pretty sure that can’t be done with GHB like drugs, but being able to metabolize such drug as a food source would automatically make it harder to OD on it. Maybe with enough use of some great drug we’ll evolve spontaneously to digest it like a food after a few million years of use.

They recently somehow genetically engineered a strain of yeast which converts sugar into morphine instead of alcohol. That boggles my mind as morphine is an incredibly more complex molecule.

Maybe the process could be reversed? Metabolized morphine into sugar. I guess this would have to be done in the gut and not the liver. Having fungus in your liver sounds like a shitty way to die.
 
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Humans, and all animals that eat plants, have evolved alongside ethanol for many millions if not a billion years. Ever since fungus started feeding off sugars produced by plants.

It's probably why our bodies are relatively efficient at metabolizing it even though it's toxic.

Most animals have a similar reaction to it as humans (drunkenness), which may point to how far back in evolution animals started to evolve to handle it.

I wonder though, do other drugs not have calories, they just don't report them?

I believe the way they calculate the calorie content of food is they sort of light it on fire and calculate how much energy it releases. Wouldn't drugs also do that?
No, they have caloric value as does wood not as does sugar and ethanol. At least all the classic one I am aware of. So even if you have a real caloric bomb in a sense of energy, think of certain plastic explosives and their supposed psychoactivity those are not used as calories in the body and like ethanol in the end if not used stored as fat.
That's actually an interesting idea. Beer could probably be made more nutritious. Although, maybe if they did it's illegal to advertise a beer as being "healthy", lol. At the very least they should add thiamine (B1).
Adding vitamin b12 to alcohol to counter some of the negative effects of chronic use (maybe even main negative when it comes to the brain if addiction and behaviour itself isn’t considered) is proposed almost the moment it was realized that one of main dangers of such use is that it causes b12 deficiency, but who the hell wants alcoholics with preserved brain, right? Sadly such is the world we live in.
They recently somehow genetically engineered a strain of yeast which converts sugar into morphine instead of alcohol. That boggles my mind as morphine is an incredibly more complex molecule.

Maybe the process could be reversed? Metabolized morphine into sugar. I guess this would have to be done in the gut and not the liver. Having fungus in your liver sounds like a shitty way to die.

Various yeasts and bacteria has been engineered to metabolize various drugs including THC, some opiods, some stimulants and loads of various non-psychoactive medicine and precursors. In fact no reason you could not train/engineer Claviceps purpurea (or something else) to produce LSD, but it isn’t worth the hassle as LSA is close enough and there isn’t a big legal market to make it fiasable like finding a morphine producing yeast. It’s worth noting that yeast does not produce morphine from sugar but metabolize something added into it . Sometimes yeast or whatever micro-organism will treat added stuff as food and sometimes as toxin but will turn it into what’s it “trained” to do. Morphine to sugar wouldn’t work or at very best would bi billion times harder than creating LSD producing micro-organism.

But I do talk about such organisms, something that could use some abundant chemical, be it some sugar to create some of better/safer alcohols or be it some amino acid or whatever.. Just as long as starting material is something that’s abundant in most places in the world. That’s the alcohol replacement we need before space age and molecular printers.
 
GHB is metabolized into succinate, which feeds directly into the TCA cycle, so it likely has caloric value.

The big thing with ethanol is its low potency. Any peptide would have nutritional value if consumed in the doses people drink ethanol.
Thnx for your reply. Knew that for peptides but didn’t for GHB.
 
Peptides as in smaller parts of amino acids but including those active in the brain, right? Hope I didn’t come as ignorant as if GHB is peptide I wasn’t aware of that. But as it’s also endogenous probably is.
 
now I wonder how many drugs are proteins
I'd guess tryptamines at least.
Tryptamines are serotonin analogues that is analog of tryptophan that is protein?
So, it should be energy then, too?
 
now I wonder how many drugs are proteins
I'd guess tryptamines at least.
Tryptamines are serotonin analogues that is analog of tryptophan that is protein?
So, it should be energy then, too?
Drugs that are proteins are rare. Venoms and toxins not so much.

And serotonin, I'm almost positive isn’t caloric in a kontekst talked here so I assume neither is any of the tryptamines.
 
Peptides as in smaller parts of amino acids but including those active in the brain, right? Hope I didn’t come as ignorant as if GHB is peptide I wasn’t aware of that. But as it’s also endogenous probably is.
Peptides require more than one amino acid. GABA is a gamma amino acid, but GHB lacks the amine, so is only a hydroxy acid.
 
I assume GHB analogues that are of so low potency that they could get quite caloric per dose?

Also beside gluconate there are some other salts that make for and caloric drug, right? Isn’t saccharate another example. GHB or some analogue in form of some of those salts is so far runner up for next most caloric drug after ethanol.
 
I assume GHB analogues that are of so low potency that they could get quite caloric per dose?

Also beside gluconate there are some other salts that make for and caloric drug, right? Isn’t saccharate another example. GHB or some analogue in form of some of those salts is so far runner up for next most caloric drug after ethanol.
Quite caloric is definately a stretch. Fatty acids have 9 kilocalories per gram, so assuming that ghb is as caloric as any other fat it's not going to give you even the calories of a cheeseburger with a pretty debauched night.
 
Anybody know what the most calorific edibles are? I mean, surely someone has launched a 'Stonedburger' franchise by now.
 
Anybody know what the most calorific edibles are? I mean, surely someone has launched a 'Stonedburger' franchise by now.
Probably those hilariously huge d9 gummies people are marketing under the hemp farm bill

Joking aside I've had a giant peanut butter cup with infused peanut butter and chocolate, that was probably the highest calorie edible I've purchased but I've added cannabinoids to my breakfast before while cooking.

Also here's a recipe for a THC infused cheeseburger


Although my pedantry won't allow me to consider cannabinoid edibles caloric drugs because the active compound isn't what's technically supplying the calories
 
Being so lipophilic, THC in a burger is a good way of increasing bioavailability.

So can we term the burger as an excipient? With a small gelcap containing 2CB being close to the other end of the scale in terms of calories.

Do we include excipients as sometimes they do alter a drugs action?
 
Kratom contains calories and of course some minerals. However the calories provided aren't significant enough to sustain a person. Not sure how accurate it is, but the kratom I've recently been getting has had a nutrition label on it and it states that 3 grams of dried leaf provides 10 calories.

I imagine any plant based psychoactive will have caloric content of some kind. I'm sure cannabis does, especially when added to a fat or vegetable. Wouldn't be surprised if Kava and Khat have a small amount of calories
 
Kratom contains calories and of course some minerals. However the calories provided aren't significant enough to sustain a person. Not sure how accurate it is, but the kratom I've recently been getting has had a nutrition label on it and it states that 3 grams of dried leaf provides 10 calories.

I imagine any plant based psychoactive will have caloric content of some kind. I'm sure cannabis does, especially when added to a fat or vegetable. Wouldn't be surprised if Kava and Khat have a small amount of calories
Yes and so do many plant based drugs. Shrooms (yeah not a plant but still) have some proteins and some of very low potency where you would have to eat hundred(s) of grams of fresh shrooms for a strong trip actually wouldn’t be that bad of a meal with some side dish. Especially given that most mushrooms are about 1/10 water they are still pretty nutritional and I kind of always wondered why they aren’t more pushed as a food but that’s another topic. Than cacti, even some succulents are used as a food, psychoactive ones are about as caloric as a next herbal tea, but up there in a top when it comes to health. Ganja used as a hole is fibery and again not caloric at al, but pretty healthy (I myself am a bit of an expert in preparing it and eating it lol). Numerous other plants that come to mind are usually at most caloric as salad, tropane salad anyone lol? There’s a couple of fruits that are pretty caloric and caloric but ofc most usual psychoactive is ethanol. Idk English name for those and some are native to Mediterian, some tree with a fruit that looks a bit like round strawberry (our name is derived from that) is known for it’s pschoactivity but it seems it contains only ethanol, way before it’s overripe. Mulberries (white and black) contain, something. So does nar (fruit that looks like a big rose bud or something). There are many other world wide but I’m interested in compounds that are caloric and none in those plants, beside ethanol are, as neither are actives from kratom.
Btw. both kava, kratom, kath, tea and coffee really do have a tiny amount of calories but again not their active compaunds.
 
Anybody know what the most calorific edibles are? I mean, surely someone has launched a 'Stonedburger' franchise by now.
Probably something I made lol. I used to bake pizza with hash, something ala English breakfast with hash, very caloric hot buttery chocolate with hash and many other caloric bombs with hash or concentrates. I’ve also made pretty good meat meals with either or even "whole" good weed. Really good weed can be used in some meals in place of rosemary and some other spices and if you do it properly it’s a delight to eat. Tho eaten enough after you use toilet after digesting it, well it’ll have a distinct smell, still somewhat incriminating lol
 
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