Cocaine Does glutamate antagonists blocks cocaine rewarding effects?

[twoface]

Hello all

Does glutamate antagonists blocks cocaine rewarding effects?

Thanks!!!

 

[sekio]

Petri Hyytiä, Pia Bäckström, Sture Liljequist, Site-specific NMDA receptor antagonists produce differential effects on cocaine self-administration in rats, European Journal of Pharmacology, Volume 378, Issue 1, 28 July 1999, Pages 9-16, ISSN 0014-2999, 10.1016/S0014-2999(99)00446-X.
(http://www.sciencedirect.com/science/article/pii/S001429999900446X)

The effects of site-specific NMDA receptor antagonists on intravenous cocaine self-administration were examined in rats trained to self-administer cocaine [...] The non-competitive NMDA receptor antagonists, dizocilpine (MK-801) and memantine dose-dependently decreased cocaine self-administration, while the competitive NMDA receptor antagonist, CGP 39551, and the NMDA/glycine receptor antagonist, L-701,324, were without effect. Under a progressive ratio (PR) schedule, dizocilpine increased the number of cocaine infusions in a manner similar to increasing the unit dose of cocaine, suggestive of potentiation of cocainereward. Conversely, memantine produced rate-decreasing effects on the PR schedule. These results demonstrate that NMDA receptor antagonists acting at different modulatory sites of the NMDA receptor do not share dizocilpine's cocaine reward enhancing effects although they are all known to be effective blockers of NMDA receptor activity.

It seems that they potentiate the rewarding effect of cocaine, rats who are trained to self administer cocaine use less when they have MK801 or memantine in them.

 

[THC2LSD]

I do know that a type of glutamate antagonist(well NMDA antagonist) PCP does not block the rewarding effects of methamphetamine. Quite the opposite in fact. There's even a combo called space base, which is crack mixed with PCP.