Does Abilify have 5HT activity, and if so, what kind?

[blase deviant]

I wanted to mix Abilify with DXM, and was wondering if this could cause serotonin syndrome.

No one in OD seems to know.

 

[almost-]

I don't think so.

Aripiprazole exhibits high affinity for dopamine D2 and D3, serotonin 5-HT1A and 5-HT2A receptors (Ki values of 0.34, 0.8, 1.7, and 3.4 nM, respectively), moderate affinity for dopamine D4, serotonin 5-HT2C and 5-HT7, alpha1-adrenergic and histamine H1 receptors (Ki values of 44, 15, 39, 57, and 61 nM, respectively), and moderate affinity for the serotonin reuptake site (Ki=98 nM). Aripiprazole has no appreciable affinity for cholinergic muscarinic receptors (IC50>1000 nM). Aripiprazole functions as a partial agonist at the dopamine D2 and the serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptor.

http://www.rxlist.com/cgi/generic/abilify_cp.htm


But OH WHY do you want to take Abilify with DXM!?

 

[blase deviant]

Well, I take Abilify for schizoaffective, and I don't have enough money for Ketamine.

 

[blase deviant]

Does anyone know? I had serotonin syndrome once and it was quite unpleasant...