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Benzos Do short-acting benzos create tolerance when given time to exit your system?

vekkersc

Greenlighter
Joined
Jul 3, 2010
Messages
47
Hello everyone,

I was hoping someone could offer some advice on the following. I made a short version and a long version of this post.

Short version: Will I still build up tolerance to short-acting benzos like Halcion and Dormicium when only taken every 72 hours, given their half-lifes are only around 6 hours?

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Long version: I suffer from severe insomnia and moderate social anxiety. Flunitrazepam used to work wonders at treating both of them, but I am starting to create a huge tolerance to it. My usual dosage used to be 4mg for quite a while. It knocked me right out within half an hour of taking it, and I slept for a good seven hours.

However, I am now forced to take it roughly three times a week, so my tolerance to it went up very quickly. Last night, it took me 8mg to put me to sleep, yet I was still only able to sleep for a total of 4 hours. I think this tolerance is due to Flunitrazepam's relatively long half-life. I don't think I'm giving it enough time to exit my system before my next dosage, so the tolerance just keeps building up.

I've tried Mirtazapine, which works wonders in putting me to sleep very quickly at only 7.5mg, but it leaves me feeling like a zombie the next day (and it's extremely hard to wake up). It also does not provide me with any anxiety relief, leaving me very socially awkward at work, which sucks big time.

So I am looking for a stronger sedative that knocks me right out, like Halcion or Dormicium, while continuing with a small dosage of Flunitrazepam for anxiety relief the next day. Since Halcion and Dormicium only have a half-life of about 6 hours, would it be fair to assume that I would not build up tolerance to either drug, when only taken every 72 hours?


Thanks for your time.
 
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Even if you do skip a day or two between doses, I believe tolerance still can develop. You may avoid physical dependence for a longer time with a schedule like that, but mentally you will still develop a tolerance to the effects of the drug. Personally, I only use benzos 3-5 times per month now a days, but due to abusing them 4 or 5 years ago I still have quite a tolerance to them.

I believe that tolerance to GABA drugs does not decrease linearly, in contrast to opiates. It is obviously more complicated than that but my point is that benzo tolerance barely goes down, even after long periods of abstinence. I used to get knocked out by .5mg alprazolam, and now I have to take at least 3mg to get a substantial effect. And this is when I take it a couple times per month.

You may be able to keep your tolerance lower, for longer, but I would still expect tolerance to grow even with shroter acting benzodiazepines such as midazolam or triazolam. Especailly in combination with flunitrazepam, your tolerance will not stay where it is at.

Benzo tolerance grows rapidly in my experience, and falls very very slowly. Use them as sparingly as possible if you want to keep your tolerance in check as best as you can.
 
There is no relation between half-life and tolerance; half-life is just a measure of how long it (generally) takes for your body to metabolize a substance, while tolerance is the process of your body adapting to the effects of the drugs. Development of tolerance is - in general - more related to potency (in terms of receptor affinity) than to the length of the effect. So if you are worried about developing tolerance, the best option is to use a low-potency, short-acting benzodiazepine, ideally without active metabolties. However, such a benzo would also be the least of help for your insomnia.

Have you already discussed this issue with your doctor? Perhaps you could ask for another approach, without benzodiazepines. Also, you might consider titrating your mirtazapine dose so it does help you get to sleep, without feeling like a zombie the next day.

Also, it is likely your benzo-tolerance exacerbates your day-time anxiety, perhaps bring this up with your doctor too...
 
Even if you do skip a day or two between doses, I believe tolerance still can develop. You may avoid physical dependence for a longer time with a schedule like that, but mentally you will still develop a tolerance to the effects of the drug. Personally, I only use benzos 3-5 times per month now a days, but due to abusing them 4 or 5 years ago I still have quite a tolerance to them.

I believe that tolerance to GABA drugs does not decrease linearly, in contrast to opiates. It is obviously more complicated than that but my point is that benzo tolerance barely goes down, even after long periods of abstinence. I used to get knocked out by .5mg alprazolam, and now I have to take at least 3mg to get a substantial effect. And this is when I take it a couple times per month.

You may be able to keep your tolerance lower, for longer, but I would still expect tolerance to grow even with shroter acting benzodiazepines such as midazolam or triazolam. Especailly in combination with flunitrazepam, your tolerance will not stay where it is at.

Benzo tolerance grows rapidly in my experience, and falls very very slowly. Use them as sparingly as possible if you want to keep your tolerance in check as best as you can.

Aw, that is very bad news for me. :!

I am currently doing therapy sessions with a psychologist for my social anxiety, and without Flunitrazepam, I absolutely cannot get the right words out of my mouth, making the treatment painstakingly slow. I suppose I'm out of options. I'm sure my psychiatrist won't even ponder allowing me to continuously increase my Fluni dosage until the psychologist therapy is finally over (probably around 6 months). Huge bummer.
 
Yeah, it is certainly a predicament I would say. While tolerance is inevitable, by taking the lowest dose possible while still obtaining the therapeutic effect needed, you can keep the rate in which tolerance grows to a minimum. Raising your dose, and taking high doses for recreation are what literally ruin your tolerance. Benzos are great tools, but abusing them typically always leads to trouble.. Addiction/dependence, huge doses just for effects, etc..

If I were you I would look into alternative remedies for your insomnia, and then switch to a longer acting, but less potent benzo to use for your social anxiety. Flunitrazepam (rohypnol) is a very strong benzo. Something like clonazapam or diazapam, or even phenazepam may be a better choice for GAD and social anxiety at work.
 
There is no relation between half-life and tolerance; half-life is just a measure of how long it (generally) takes for your body to metabolize a substance, while tolerance is the process of your body adapting to the effects of the drugs. Development of tolerance is - in general - more related to potency (in terms of receptor affinity) than to the length of the effect. So if you are worried about developing tolerance, the best option is to use a low-potency, short-acting benzodiazepine, ideally without active metabolties. However, such a benzo would also be the least of help for your insomnia.

Have you already discussed this issue with your doctor? Perhaps you could ask for another approach, without benzodiazepines. Also, you might consider titrating your mirtazapine dose so it does help you get to sleep, without feeling like a zombie the next day.

Also, it is likely your benzo-tolerance exacerbates your day-time anxiety, perhaps bring this up with your doctor too...

Thanks for you reply. I have been considering the mirtazapine option, although it seems that a 7.5mg dosage is the only one that knocks me right out, but leaves me feeling like crap the next day. It's a huge struggle trying to be productive at work. I just feel tired, zombified, and completely unmotivated during the entire day.

I've tried 15mg as well, but that dooesn't help me sleep nearly as well as 7.5mg. It'll leave me rolling in bed for a good 2-3 hours before I can finally sleep, and when I wake up, I still feel zombified :|

I'll try a dosage lower than 7.5mg and see how that works out.

We have exhausted almost all non-benzo sleep aids with no effect whatsoever. I could name over a dozen non-benzo sedatives that had no effect on me, and my psychiatrist only switched me to Fluni after we had already tried all other options. The only non-benzo that puts me to sleep is Mirtazapine.

I haven't spoken to my psychiatrist about the tolerance issue because my health plan only allows me to see him every 45 days, and it's only been two weeks since my last visit. This increased tolerance to Fluni developed literally in a matter of a week, as I've had to make more frequent use of it. I was hoping to stay off it for about 4 days to see if my tolerance would come back down, but as you guys said, I don't think that's going to work.

In the meanwhile, I suppose I could try Mirtazapine for sleep, and a low dosage of Fluni in the mornings, for anxiety. Not sure that's going to work.

I'll definitely ask him about a low-potency, short-acting benzo, as you suggested. However, did you mean I should take it at night along with Mirtazapine, or in the mornings? Also, as I asked BrokedownPalace, wouldn't my tolerance to Flunitrazepam make this low-potency benzo ineffective?

Yeah, it is certainly a predicament I would say. While tolerance is inevitable, by taking the lowest dose possible while still obtaining the therapeutic effect needed, you can keep the rate in which tolerance grows to a minimum. Raising your dose, and taking high doses for recreation are what literally ruin your tolerance. Benzos are great tools, but abusing them typically always leads to trouble.. Addiction/dependence, huge doses just for effects, etc..

If I were you I would look into alternative remedies for your insomnia, and then switch to a longer acting, but less potent benzo to use for your social anxiety. Flunitrazepam (rohypnol) is a very strong benzo. Something like clonazapam or diazapam, or even phenazepam may be a better choice for GAD and social anxiety at work.

Thanks for your thoughts! Your post seems pretty much in line with what 3rd_I_blind said. You mentioned I should consider switching to a longer acting, but less potent benzo to treat my anxiety. Wouldn't my tolerance to Flunitrazepam make this low-potency benzo ineffective? Also, as I asked 3rd_I_blind, should this benzo be taken at night or during the day?

I realize these are all questions I should be asking my psychiatrist, but since my next visit will only be in over a month's time, I am a little desperate, as I still have a lot of real-life issues to deal with, which I can't tackle with anxiety problems and getting no sleep at all. I'm on the verge of being fired due to lateness, missing too many days of work, not to mention my poor relationship with others at work due to GA. Quite literally, FML.
 
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I have my own theory in which I think the occasional use of a short-life benzo has less impact on tolerance and withdrawal than the longer acting ones. Why not the longer the half life the more time your body has to build tolerance and addiction to it? Valium is going to work for a long time in your body yet the effects wear off after a few hours. Perhaps this is due to tolerance developing.
But you say you are developing tolerance anyway so I'd watch out and quit while you can. Your sleeping issues will get worse along with the more tolerance it builds. There must be a natural ligand for the bzd receptor made in the body that is not going to perform its function correctly after benzo use.
 
Ideally you want to learn how to deal with social anxiety and GAD without medication. I am sure you already know this. But if you were to switch to a weaker benzo than rohypnol, I wouldn't say it would be ineffective. Therapeutic effects can still be present without the feeling of intoxication. Sometimes this lack of "feeling it" can be translated to thinking that the drug is not working, which isn't necessarily the case.

Benzos work best when used short term, but the reality is that some people need benzos for life basically, in order to function properly and carry on with a normal life at work, home, etc. I feel like I am one of those people, as well. So I sympathize with your situation, and wish I had better answers or the solution to your problem.

Personally, since we seem quite similar, by preferred benzo regimen is diazapam or clonazapam. Diazapam, because of the added muscle relaxation properties it possess. Dosing in the morning when I wake up, and then in the evening is what I do, which allows me to have the therapeutic value of the drug be effective for the work day, and the evening dose helps me when I go out and socialize, and helps sleep as well. Twice daily, or perhaps even three times, allows peak plasma levels to build up and have an effective dose working for the maximum time.

It is a double edged sword, though, unfortunately.. Chronic benzo use certainly helps when used responsibly, but if for some reason you get cut off or run out or whatever you are pretty much fucked. I have been through bad benzo withdrawal before and it is no fun. Opiate withdrawal is childs play in comparison.

I see that you can only see your doctor every forty-five days, but surely you can call him, no? He shouldn't have a problem discussing these issues with you via telephone.
 
^Brokedown makes a good point, a lot of people think benzos "aren't working anymore" because they don't feel any effects. This is obviously different for people who use benzos recreationally and people who use benzos medically. I realize there is a large group of people who use them for both purposes (I am one of those people). Don't get sucked into thinking that your benzo isn't working just because you aren't feeling it.

In general, as Brokedown said, the longer-acting benzos are better for reducing how quickly your tolerance goes up, at least in my experience. I used to use alprazolam (Xanax, prescribed), and even though that benzo is very much a "peaks and valleys" benzo, my tolerance was increasing quicker and my anxiety was up and down with the effects of the Xanax. Xanax also completely erased my memory, I don't know if that's a problem with flunitrazepam or not but just wanted to throw that out there, shorter-acting benzos tend to do that. I tried SSRIs for a minute, horrible sexual side effects, not for me.

Got switched to lorazepam which is nicer, I've been on it for almost a year now and 0.5mg still works wonders for stopping anxiety right in its tracks, 1.0mg for a serious anxiety attack. So, tolerance can be kept down with sparse use and understanding that even though you don't feel the intoxicating/recreational effects of the benzo in question, it is most likely still working its magic.

Short version:
Benzos are the ultimate double-edged sword, please treat them with respect and only use them when you need them. If another drug works for helping you sleep, I say give that a shot. Your doctor should be understanding in regards to this. Good luck :)
 
I'll definitely ask him about a low-potency, short-acting benzo, as you suggested. However, did you mean I should take it at night along with Mirtazapine, or in the mornings? Also, as I asked BrokedownPalace, wouldn't my tolerance to Flunitrazepam make this low-potency benzo ineffective?
Most of this questions are not really for us to decide, since giving an answer is forcing me/us to 'play doctor' while we don't know your situation and have no mental healthcare background. I'll give my opinion on the matter anyway, but please keep in mind it is just my opinion and you should at least give your doctor a call before making drastic changes to your drug regimen.

I think you'll be best off if you only resort to benzo if you have a real anxiety attack. The baseline anxiety you are feeling everyday seems to be (in my opinion) more related to your benzo dependence than that it is intrinsic anxiety. Since dependence and tolerance go hand-in-hand, your general anxiety will decrease as your tolerance is degenerating. Of course it is shitty to feel anxious all day, but suppressing this anxiety with your benzo is only making matters worse - eventually you might end up in a situation were you can't do anything without taking large amounts of benzo's.

Tolerance in case of benzodiazepines is always a general tolerance, so if you are tolerant to flunitrazepam you are also tolerant to diazepam etc. etc. However, it is not necessarily so that a lower potency benzodiazepine is absolutely useless once you have a tolerance. You just need more to reach the desired effect, but it's not like you should switch to more and more potent alternatives because of tolerance. Furthermore, switching to a lower potency substance gives you chance to lose the tolerance - but only if you can refrain from dosing too much.

BTW, as far as science knows there is no natural ligand for the BZD receptor. In fact, the BZD is just another name for the GABAa receptor subtype that has a binding site for benzodiazepines. But unlike most other drugs that bind to receptors, benzodiazepines do not activate but alter the conformation of the receptor protein, so it has a greater affinity for GABA. Therefore it does not mimic the endogenous ligand, it potentiates the effect of this ligand.
 
Yes, tolerance will still built even if you take it every 72 hours (this is the case with all benzos, but especially with short acting ones).

Flunitrazepam is not a good benzo for daytime anxiety. Flunitrazepam, like triazolam, midazolam, temazepam, etc is meant for severe insomnia. They are highly sedative benzos that will knock you right into tomorrow. You'd be better off with something like diazepam for daytime anxiety. Clonazepam is another good choice.
 
Hell yes, what makes you think this would have any real effect at all?
So, like, does that mean if I just do heroin ever other day (not evvverydayy cmon guis, repeatedly, I will totally avoid being subject to all of that tolerance I hear is a bitch? NO!? you're no fun I'm just going back to drinking

Doing more of a class of chemical, causes the effects linked to..increased consumption of that chemical, and other structurally similar drugs as well (cross-tolerance).

The theory that the drugs with sharp peaks and crashes, as well as shorter half lives (High hill to flat ground ratio you know) often lead to a compulsive need to constantly re-dose, hence almost exponentially growing consumption and therefore tolerance, and, as compared to other drugs with long peaks and smooth slopes, the dose increase, and often the tolerance is much more slowly accumulating...but, its there. For me, I'm poor, Phenazepam for drool

I am not sure if you were being a little aggressive in your first statement. I was just looking for some advice, as I am new to benzos. The rest of your post was a little hard to understand, but I think I got the jist of it. Thanks for your reply :)

I have my own theory in which I think the occasional use of a short-life benzo has less impact on tolerance and withdrawal than the longer acting ones. Why not the longer the half life the more time your body has to build tolerance and addiction to it? Valium is going to work for a long time in your body yet the effects wear off after a few hours. Perhaps this is due to tolerance developing.
But you say you are developing tolerance anyway so I'd watch out and quit while you can. Your sleeping issues will get worse along with the more tolerance it builds. There must be a natural ligand for the bzd receptor made in the body that is not going to perform its function correctly after benzo use.

Thanks for your reply. Based off what you said, does this mean that my tolerance to Flunitrazepam will forever make it more difficult for me to fall asleep, or if I stay off it for good, it will come back to normal?

When I said I suffer from severe insomnia, there was actually a little more to it. The condition I have is often described as Non-24-hour sleep-wake syndrome. If you don't feel like reading all that, it basically means that my natural internal clock is wired at 36 hours. 24 hours being awake, and 8 hours sleeping. If a day consisted of 36 hours, I wouldn't need any medication at all. Apparently, melatonin supplements helps with this, but they are illegal where I live. :X

Ideally you want to learn how to deal with social anxiety and GAD without medication. I am sure you already know this. But if you were to switch to a weaker benzo than rohypnol, I wouldn't say it would be ineffective. Therapeutic effects can still be present without the feeling of intoxication. Sometimes this lack of "feeling it" can be translated to thinking that the drug is not working, which isn't necessarily the case.

Benzos work best when used short term, but the reality is that some people need benzos for life basically, in order to function properly and carry on with a normal life at work, home, etc. I feel like I am one of those people, as well. So I sympathize with your situation, and wish I had better answers or the solution to your problem.

Personally, since we seem quite similar, by preferred benzo regimen is diazapam or clonazapam. Diazapam, because of the added muscle relaxation properties it possess. Dosing in the morning when I wake up, and then in the evening is what I do, which allows me to have the therapeutic value of the drug be effective for the work day, and the evening dose helps me when I go out and socialize, and helps sleep as well. Twice daily, or perhaps even three times, allows peak plasma levels to build up and have an effective dose working for the maximum time.

It is a double edged sword, though, unfortunately.. Chronic benzo use certainly helps when used responsibly, but if for some reason you get cut off or run out or whatever you are pretty much fucked. I have been through bad benzo withdrawal before and it is no fun. Opiate withdrawal is childs play in comparison.

I see that you can only see your doctor every forty-five days, but surely you can call him, no? He shouldn't have a problem discussing these issues with you via telephone.

My usage of benzos is roughly every 3 days. I am not sure if this means I'll be fucked when I stop taking them. There was a period a few months ago when I stopped taking Fluni completely, and started taking Mirtazapine in in its place. It did wonders at fighting back the withdrawal symptoms, but the social anxiety was still there.

I can't really call my doctor unfortunately. The most I can do is send him an e-mail asking for a prescription and explaining the reason I need it.

I do agree with you that ideally I should seek treatment for GAD without benzos, although without them, it would take me forever to give my psychologist the right answers due to anxiety. I would need a lot more therapy sessions, and simply would not be able to afford paying for them all, be it on a short or long term basis. I really don't know what to do about this, it feels as if I'm trapped.

^Brokedown makes a good point, a lot of people think benzos "aren't working anymore" because they don't feel any effects. This is obviously different for people who use benzos recreationally and people who use benzos medically. I realize there is a large group of people who use them for both purposes (I am one of those people). Don't get sucked into thinking that your benzo isn't working just because you aren't feeling it.

In general, as Brokedown said, the longer-acting benzos are better for reducing how quickly your tolerance goes up, at least in my experience. I used to use alprazolam (Xanax, prescribed), and even though that benzo is very much a "peaks and valleys" benzo, my tolerance was increasing quicker and my anxiety was up and down with the effects of the Xanax. Xanax also completely erased my memory, I don't know if that's a problem with flunitrazepam or not but just wanted to throw that out there, shorter-acting benzos tend to do that. I tried SSRIs for a minute, horrible sexual side effects, not for me.

Got switched to lorazepam which is nicer, I've been on it for almost a year now and 0.5mg still works wonders for stopping anxiety right in its tracks, 1.0mg for a serious anxiety attack. So, tolerance can be kept down with sparse use and understanding that even though you don't feel the intoxicating/recreational effects of the benzo in question, it is most likely still working its magic.

Short version:
Benzos are the ultimate double-edged sword, please treat them with respect and only use them when you need them. If another drug works for helping you sleep, I say give that a shot. Your doctor should be understanding in regards to this. Good luck
Thanks for your thoughts! When I say that Flunitrazepam isn't working anymore, all I really mean is that it's not putting me to sleep, at all. Its social anxiety relief is still present the next day, strangely enough. As I mentioned earlier, my psychiatrist and I have gone through a long list of non-benzos to help me sleep, none of which worked except for Mirtazapine. However, it does not help with social anxiety, nor with my therapy sessions. I prefer going to work not having slept at all than having taken Mirtazapine the night before, as it leaves me completely zombified and unproductive.

Would you mind elaborating a little on your lorazepam usage? How often do you use it? Do you take it at night or during the day? I've noticed that a small dosage of Flunitrazepam in the morning helps me with anxiety throughout the day. I was thinking about doing this three times a week, while making use of a non-benzo other than Mirtazapine for sleep (which I have yet to find). I'm not sure if it would be a good idea to take Flunitrazepam three times a week in the mornings, in terms of tolerance and dependence, though. Thanks again.

Most of this questions are not really for us to decide, since giving an answer is forcing me/us to 'play doctor' while we don't know your situation and have no mental healthcare background. I'll give my opinion on the matter anyway, but please keep in mind it is just my opinion and you should at least give your doctor a call before making drastic changes to your drug regimen.

I think you'll be best off if you only resort to benzo if you have a real anxiety attack. The baseline anxiety you are feeling everyday seems to be (in my opinion) more related to your benzo dependence than that it is intrinsic anxiety. Since dependence and tolerance go hand-in-hand, your general anxiety will decrease as your tolerance is degenerating. Of course it is shitty to feel anxious all day, but suppressing this anxiety with your benzo is only making matters worse - eventually you might end up in a situation were you can't do anything without taking large amounts of benzo's.

Tolerance in case of benzodiazepines is always a general tolerance, so if you are tolerant to flunitrazepam you are also tolerant to diazepam etc. etc. However, it is not necessarily so that a lower potency benzodiazepine is absolutely useless once you have a tolerance. You just need more to reach the desired effect, but it's not like you should switch to more and more potent alternatives because of tolerance. Furthermore, switching to a lower potency substance gives you chance to lose the tolerance - but only if you can refrain from dosing too much.

BTW, as far as science knows there is no natural ligand for the BZD receptor. In fact, the BZD is just another name for the GABAa receptor subtype that has a binding site for benzodiazepines. But unlike most other drugs that bind to receptors, benzodiazepines do not activate but alter the conformation of the receptor protein, so it has a greater affinity for GABA. Therefore it does not mimic the endogenous ligand, it potentiates the effect of this ligand.
Thank you, I appreciate your reply. My anxiety issues are linked to childhood psychological problems, which I am dealing with my psychologist. Before I started taking Flunitrazepam, I still suffered from anxiety and had a lot of difficulty dealing with the social environment at work. Same case with the insomnia. It has always taken me between 4 and 8 hours rolling around in bed until I could finally sleep, even before I started taking any sleep medication. This drug was my last resort to not losing my job due to both insomnia and anxiety. I have tried lower potency benzos such as Diazepam and Zolpidem. Diazepam was as good as placebo, and Zolpidem built up tolerance way too quickly (but I made way too frequent use of it), not to mention it made irritable the next day. I will definitely not try a more potent benzo, as you do raise a valid point. Right now I am only looking for an alternative that will not make me lose my job due to lack of sleep or poor relationship with my co-workers. :\

Yes, tolerance will still built even if you take it every 72 hours (this is the case with all benzos, but especially with short acting ones).

Flunitrazepam is not a good benzo for daytime anxiety. Flunitrazepam, like triazolam, midazolam, temazepam, etc is meant for severe insomnia. They are highly sedative benzos that will knock you right into tomorrow. You'd be better off with something like diazepam for daytime anxiety. Clonazepam is another good choice.

Thank you for clarifying that for me. Based on my own experience, I find a low dosage (2mg) of Flunitrazepam in the morning does not make me sleepy at all. It just relieves anxiety. Diazepam, as I mentioned in my previous post, had no effect on me. I haven't tried Clonazepam, so I suppose that is something I could look into. Thanks!
 
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Would you mind elaborating a little on your lorazepam usage? How often do you use it? Do you take it at night or during the day? I've noticed that a small dosage of Flunitrazepam in the morning helps me with anxiety throughout the day. I was thinking about doing this three times a week, while making use of a non-benzo other than Mirtazapine for sleep (which I have yet to find). I'm not sure if it would be a good idea to take Flunitrazepam three times a week in the mornings, in terms of tolerance and dependence, though. Thanks again.

Not a problem, I'm currently prescribed 1mg lorazepam per day for panic disorder, I usually take 0.5mg in the late afternoon/evening to relax me after a long day, but since I've been unemployed as of late my consumption of lorazepam (and other drugs) has decreased, probably because I'm less stressed and have less overall anxiety. My doctor instructed me to take 1mg in the late morning if I feel like I need to, but he was pretty vague about dosing besides that, which is fine. I prefer being able to decide my dosing and frequency of dosage.

I do sometimes take 1mg at a time, but its quite rare, even if I do go up to 1mg total, it split into two 0.5mg doses throughout the day, as lorazepam's duration of action isn't long enough for dosing in the morning. I am able to take days and days off from lorazepam without problems, and I try my best to at least take a 24 hour break between using it. I'm surprised my tolerance isn't higher, to be honest, even with those low dosages I've still been using it for much longer than "2-4 weeks".

What really helps my anxiety is knowing I have lorazepam on hand to knock a full-blown panic attack down in its tracks.

As far as the 36 hour sleep cycle thing goes, is melatonin completely illegal in your country or is it RX-only? I've been using melatonin a lot recently and it helps put me to sleep better than any benzo I've tried.
 
It happens to me as well, I think its a combination of being on a shared wireless connection and the bluelight server being on the other side of the planet, no worries my friend :)
 
Not a problem, I'm currently prescribed 1mg lorazepam per day for panic disorder, I usually take 0.5mg in the late afternoon/evening to relax me after a long day, but since I've been unemployed as of late my consumption of lorazepam (and other drugs) has decreased, probably because I'm less stressed and have less overall anxiety. My doctor instructed me to take 1mg in the late morning if I feel like I need to, but he was pretty vague about dosing besides that, which is fine. I prefer being able to decide my dosing and frequency of dosage.

I do sometimes take 1mg at a time, but its quite rare, even if I do go up to 1mg total, it split into two 0.5mg doses throughout the day, as lorazepam's duration of action isn't long enough for dosing in the morning. I am able to take days and days off from lorazepam without problems, and I try my best to at least take a 24 hour break between using it. I'm surprised my tolerance isn't higher, to be honest, even with those low dosages I've still been using it for much longer than "2-4 weeks".

What really helps my anxiety is knowing I have lorazepam on hand to knock a full-blown panic attack down in its tracks.

As far as the 36 hour sleep cycle thing goes, is melatonin completely illegal in your country or is it RX-only? I've been using melatonin a lot recently and it helps put me to sleep better than any benzo I've tried.

Thanks again for your reply. I will definitely talk to my doctor about a less potent, longer-acting benzo to take in the mornings.

As for Melatonin, it is simply not available where I live, although it used to be at one point. The large pharmaceutical companies bribed the Government to remove it from the market because other tranquilizers such as fluoxetine and clonazepam are more profitable. That's the true, sad reality of the situation.

The only way I can obtain Melatonin is by asking relatives who live in the US to ship me a bottle in a generic, disguised box, so the Gov't doesn't confiscate it. I've heard a lot of positive things about it and would love give it a try.
 
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It happens to me as well, I think its a combination of being on a shared wireless connection and the bluelight server being on the other side of the planet, no worries my friend :)

It is a site wide issue, we are all experiencing it. The admins/engineers are working hard at fixing it, though. It certainly is getting better over the past couple of days, though.
 
@ vekkersc - I should have mentioned in my other post, I've used clonazepam as well (not prescribed it, but its everywhere) and I like how its longer-acting than lorazepam, but, at least for me, it is far too sedating. Your mileage may vary, however, a lot of people prefer clonazepam over lorazepam for other reasons, I view them to be equals excepting for the sedating aspect, which, in some cases, is a good thing.

@ BrokedownPalace - I wasn't aware this was a system wide problem, I thought it was due to crappy wireless environments where I connect to Bluelight...good to hear its being worked on though!
 
Is there anything one can do to reverse tolerance to benzodiazepines after heavy recreational abuse? I am currently prescribed Seroquel, for bi-polar disorder, 100mg to be taken before bed, though I do not take it as I don't need it. Also, I am prescribed alprazolam 2mg to be taken 3 times a day for panic disorder. Now, I'll be honest, though I do have a problem with anxiety and used to be severely depressed, I don't believe that my psychiatrist's diagnosis of bi-polar disorder type I is accurate, and whilst from time to time I do get extremely anxious and panicked, mostly in social situations, the panic disorder label is inaccurate too. But I do have regular access to cheap, government subsidized, Xanax. My fiance and I are both opiate addicts, heroin is our poison - of course, and we're currently taking buprenorphine (Subutex) daily as part of a maintenance program. Initially, we were taking 32mg sublingually for the first year or two but we've now weened ourselves down to around 8mg IV each day. Anyway, though heroin and any opiate for that matter is our drug of choice, we love our benzos. In between scripts, when we run out, we purchase Xanax, Valium and Rivotril on the street. I would say we use, or binge is probably a more accurate term, a few times each month with around 6 weeks being the longest break in between useage. Now, we take I've been told are obscene amounts of benzos; a bottle of 50 2mg Xanax will taken care of over the course of a night. That's 25 2mg alprazolam each which equates to 50mg alprazolam. Generallly we will start with 10-16mg each as sometimes after such a dose we will feel absolutely no effect whatsoever and other times it'll be messy and only bits and pieces of memory remain as to what we got up to. It is not unheard of for us to take 40mg of clonazepam each in one mouthful, and regardless of the dose I hardly ever get any effect from clonazepam. Large doses of diazepam sometimes work great and other times I wouldn't have known that we had ingested any drugs at all. My first question is this, has/does anyone else take doses like this of the aforementioned drugs? And if so, how do they effect you? Secondly, why is it that sometimes the recreational effects of the drugs can be significantly felt and quite enjoyable, yet other times we experience absolutely nothing whatsoever? And thirdly, if this is a question of tolerance, and I believe it may very well be as when I first started taking Xanax 4-6mg would utterly floor me, my partner also, is there any way that we can reduce said tolerance by taking any supplements or medications that may help alleviate this fear that one day we won't be able to get nicely molested by benzodiazepines? I look forward to any information that you guys might be able to share. :)
 
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