DNP mini cycle gone wrong

Hexagon Sun

Hexagon Sun

Bluelighter
Joined
Mar 29, 2010
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Spain
After reading for a week or 2 pretty much everything I found on DNP Im ready to start it.

It takes like 36h to notice the heat. I take around 200-300mgs day. Winter is coming so the feeling is great. But at the 3rd day I get some serious fatigue. I go to the gym but at the second machine I give up. I have the strenthg of a little child. I spent the rest of the session doing light cardio.

On nights I can sleep with no much trouble but in the mornings Im wet like coming from the swmming pool. I can stand the fatigue and changing the sheets 2 a day. Im also getting hungry like an african daddyless child and obssesely fantasizing with food 24h

At the 5th day I weight myself. I was thinking I should have lost like 4-5 pounds, right? Like 1 pound day, which is the typical success report using DNP. Well, fuck, no. Im only 1.5 pounds lighter. So 5 days sweating like a bastard, non able to go to the gym and hungry like a mf beast to lost 120miligrams a day doesnt cut it. At all

There are reports that the week after you stop the DNP you still lose more weigth as you were water bloated.

In my case, I have not lost a micra, but gained 1.2kilos from day 0. Almost 3 pounds, For fucks sake. Somehow Im more hungrier that at the begining of the experiment. And it seems I have lost some autocontrol about feeding.

Before some say: I also added t3, and I think that helped to catabolize even more muscle. So pretty much everything went wrong in this 5 days experiment

The only good feeling was to recover the muscular strength again after 3 or 4 days off the drug

I dont think Im repeating it soon, but If I were, In retrospective, I think I should have stocked ephedrine to help with appetite suppression and be extra clear with myself that I must keep the diet under control, but it starts to be like a stack of poisons, one over the other... So currently looking at another strategies

Semaglutide seems like a revolution on weight loss. Currently looking to source it. It´s the most expensive peptide I have ever see, by a long shoot
 
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Hmm, you say you read about it for two weeks, but seem surprised that your appetite went thru the roof? You really have to control how much you eat on this stuff. Sticking to a diet religiously and keeping a detailed food diary helps. Too many people think they can just eat whatever and will still lose weight but that doesn't usually happen.

Personally I found DNP to be an excellent tool but it took a while for me to find the best strategy for my own body.
 
CFC said:
Hmm, you say you read about it for two weeks, but seem surprised that your appetite went thru the roof? You really have to control how much you eat on this stuff. Sticking to a diet religiously and keeping a detailed food diary helps. Too many people think they can just eat whatever and will still lose weight but that doesn't usually happen.

Personally I found DNP to be an excellent tool but it took a while for me to find the best strategy for my own body.
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Yeah, totally. I fell in all the newbie traps. I also think that I overdosed t3. From day 3 I started taking 40mcgs, which did the hunger even worst. I should have probably stick to a third of that dose

My math was like, people are losing a pound per day, with is near 4000cals, ok? So if I eat just a bit more Im still losing a hackathon of cals. Wrong. You also have to note that as long as you spend the day in the bed doing basically nothing, your expenditure goes south too.

Whay would be perfect is to find a dosage, maybe 50 or 100mgs day, that elevates the caloric waste but keep the glycogen so you can pretty much do normal life. Does it sounds reasonable?. I dont feel like find it out in myself now, tho

One of the big lessons here is that I fucking love my glycogen storage full and ready to rock

I also found something about microdosing DNP for cognitive effects but I didnt follow that rabbit hole...
 
Some info on DNP from an old friend:

Basically the mitochondria are the power factories of the cell. Just like the entire cell itself and it's core containing it's lined with a lipid layer that protects it from just anything getting in there, that's why transport molecules like carnitine are needed to shuttle acyl groups into the mitochondria. The layer around the mitochondria is unique in that it's actually a double layer. Inside the inner layer, the actual inside, is where the citric acid cycle occurs. acetyl-CoA, the final product of food, is taken through a 4-complex system that breaks it down and at each step, protons (H+) is created and pumped into the middle layer between its two membranes. So this outer space is full of protons, and the inside of the mitochondria are devoid of them, which creates a gradient where the protons desperately want to get to the inner space where the concentration of protons is lower. The only way they can get there is through the ATP synthase gates. Because of the flow of protons through the ATP synthase it is activated (look at it like a wind or water mill) and energy in the form of ATP is created.

DNP is basically a very fat soluble aromatic ring with two nitrogen groups and a hydroxyl group (OH). It likes to nest inside lipid layers. All of them. But it doesn't do anything in most lipid layers, except the inner lipid layer of the mitochondria. The inner space is devoid of protons and creates a gradient with the outer space. It starts pulling on the DNP, rotates it's OH group towards the inner space and rips it's proton (H+) off. This leaves an O-. This negatively charged group wants its proton back but can't beat the gradient. However a different gradient is created by the protons in the outer space pulling that negatively charged O- toward it and donating one of the gazillion of H+ ions yielding the neutral OH again.

This makes the gradient pull the DNP toward the inner space again and the process repeats ad infinitum as long as there is a gradient. Basically you create a proton leak. The result is that ATP synthase doesn't work and ATP creation is "uncoupled" from the citric acid cycle, and all that energy is released as heat. But the body senses an energy shortage, and starts asking for more food to be delivered to the mitochondria; so the gradient is always maintained (also why DNP makes you hungry). This isn't regulated by anything but the dose of DNP. So at some point zero ATP is created, and the heat levels in the body become dangerous to all physiological processes. This can result in death. Very few of the recent deaths associated with it are accidental, a few people tried to kill themselves with it knowing it was lethal. Sadly not knowing it's not a pleasant way to go, as it can take three days to die, full well knowing by day 2 they can't do anything to help you and having 48 agonising hours left. Trust me, you don't want to go this way, so give this compound the respect it deserves.

You always start at a dose of 150-250mg from a trustworthy source recommended by someone you trust, or you simply don't try it. You keep that dose for at least 5 days because DNP builds up and you want to know how you react to a dose before you increase it. The two times I used it, I started at 200, increased to 400 and stayed there for 3 weeks. The first two weeks were actually very manageable. Fatigue, lethargy and lack of strength set in and you sweat more. But you can still function. The last two weeks however are a living fucking hell. The sweating gets so bad you change T-shirts three times a day (don't wear one if you don't have to) have to shower multiple times a day. At night you sleep on a mattress, no sheets, window open in the middle of winter and two fans aimed at you, your pillow wrapped in a towel and you still wake up in a pool of sweat.

DNP also comes with other risks, it is a very strong oxidant that depletes anti-oxidant levels quick. Anti-oxidants are needed, but none more than Vitamin C, Vitamin E and curcumin. VIT-C and E were actually already being recommend by Dan Duchaine, and without knowing why that recommendation took on a life of its own and people megadosed it. That really isn't necessary, but taking 500-1000mg of C and 400-800mg of E daily is warranted, since those are the anti-oxidants needed in the eye. In fact this is the likely reason why DNP use can cause cataract and blindness in people. VIT E, C and curcumin have actually been shown to stop the progression of cataract. You may or may not need these, but we are talking about losing your sight, so you may not want to be taking that risk.
In fact I'd consider this the biggest risk if you use it more than once. If you are careful, with a protocol like above, and not the shitty 1 week build up to 800-1000mg DNP protocols some recommend, then trust me you'll realize perfectly well you shouldn't be going higher. In fact I don't ever use DNP anymore, because the result over a complete diet is the same for me, and the suffering is just as bad. The only thing is that with DNP, across a 3-4 day span each time, the fat loss was almost linear and very dependable, like 0.3-0.4kg a day. That makes timing your diet very easy.

Having said that, DNP use has to stop AT LEAST 3 weeks out from any competition. As you can lose 8-10kg in 4 weeks, you won't really notice it visually, as you'll be flat, miserable and full of water. It'll take at least another week for the DNP to clear your body sufficiently, and then another week to return to normal, visually, leaving you with prep week only to fine tune things.

To give you an idea of how toxic DNP is to cells, have any of you ever had a fungus on your toenail ? Do you know how long you have to apply those treatments to get rid of that ? Like twice a day for 4-5 months. I had one my first time on DNP. That fungus was gone in a week on DNP. Cellular respiration stops. In simple organisms like fungi and bacteria that's instant death.

Like insulin it is a very dangerous and potentially lethal compound, but the risk of that becomes almost nil if you are well informed, and once you know how you react to it, and what to watch for.
 
I had the same experience as GF. 250mg is my sweet spot where I can function at generally a good physical capacity. I put on a few lbs of water out the gate then it ate through my glycogen like crazy and then I flattened out. Massive weight loss in a deficit due to glycogen and water weight dropping initially. Then it slowed down. Took about 10 days for the DNP to clear and fill back out completely. The mechanism of action is pretty neat though as we covered it in one of my classes lol.
 
Some info on the DNP in microdoses as a cognitive enhancer/nootropic

TLTR; at 1 to 25mgs/day it helps with cognition/anti alzehimer, better mitocondrial health and a gazillion more claims

One user that took it everyday at 250mgs for 4 years straigh reports this:

I have been on a low-dose of DNP for nearly 4 years and figured some of you may be interested in hearing about my experience.

Most consistently, I used a low dose, 250 mgs, every other day. I experimented with doses up to but no more than 500 msg everyday. The results have been life-changing. I truly believe DNP to be one of the best supplements available for metabolic health and life-extending purposes. Over the four years I have never been sick with the exception of contracting mononucleosis about 2 years ago. I used to be very susceptible to sickness and infections. My energy levels and sense of well-being are high, my hormone levels are all in healthy ranges, my body composition is excellent and more resilient to bad diets and lack of exercise, and I even believe I sleep better. Metabolism remains at an elevated state, even upon cessation. I believe it is helping to maintain mitochondrial health and perhaps could help reverse age-related mitochondrial decline. It reduces ROS and has improved my insulin sensitivity and glucose tolerance. I have suffered no known negative side-effects and do not use supplements to mitigate its side effects, nor do I believe it to be necessary. I do not necessarily believe DNP to be solely responsible for my excellent state of health, but do believe it has helped maintained a healthy metabolic environment, which as a result has improved my general health and well-being.

My concerns: I plan to continue DNP supplementation perhaps for the extent of my life. I have reviewed libraries worth of literature on the subject and have found little reason to discontinue, but if you believe there are significant concerns that should be addressed I would be delighted to hear your insight. My primary concern is cataracts. At the doses I take I have not noticed a yellowing of any tissue or bodily fluids. At higher doses, though, I did experience yellowing of bodily fluids. I'm concerned about the possibility that DNP may deposit yellow pigments into the lens of the eye, facilitating the cataract development that is sometimes reported. At this point, and with the doses I use, I hope this does not become a problem. Annual eye appointments have not suggested it to be a problem as of yet, but never-the-less it is a concern of mine.

Second, I wonder the impact of DNP on gut microbiota. I would assume that DNP-mediated mitochondrial uncoupling would occur in the gut bacteria as well. I don't know if this would promote healthy bacterial colonization or reduce it. I have not noticed any significant gut-related problems but I still plan to have a stool analysis performed some day. Although, it may not be too revealing as I have had a strong medical history with antibiotic use, up until about 4 years ago.
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Yeah - DNP is illegal in most places.... because of the death toll.

DNP overdose will cause fatal hyperthermia, with body temperature rising to as high as 43.1 °C (109.6 °F) shortly before death. Case reports have shown that an acute administration of 10–20 milligrams per kilogram of body weight in humans can be lethal.

I'm just shocked that people keep on taking it, especially since it's also a bioaccumulating pesticide.
 
Fertile said:
Yeah - DNP is illegal in most places.... because of the death toll.

DNP overdose will cause fatal hyperthermia, with body temperature rising to as high as 43.1 °C (109.6 °F) shortly before death. Case reports have shown that an acute administration of 10–20 milligrams per kilogram of body weight in humans can be lethal.

I'm just shocked that people keep on taking it, especially since it's also a bioaccumulating pesticide.
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The lethal dose is very close to a normal dose, and that coupled with the long half life make it very dangerous.
But AFAIK all deaths caused by it have been people that bought it as a magic pill to get lean without knowing anything about it and thought taking more would be better.
 
Phobos said:
The lethal dose is very close to a normal dose, and that coupled with the long half life make it very dangerous.
But AFAIK all deaths caused by it have been people that bought it as a magic pill to get lean without knowing anything about it and thought taking more would be better.
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Interesting that some makers get around the law by offering sodium dinitrophenolate.

But if anyone is taking an unknown 'fat burner' is just shows that those who take drugs as part of their physical training are by far the LEAST informed. I've been temped to buy those multidose vials and plaster any old steroid name onto them.
 
The microdoses im talking in the previous post are 1 to 25mgs total per day, not per kilo. Pretty much everyone knows that DNP is deadly in the hands of a retarded.

I love to experiment all kind of substances and biohackings of all colors. 90% of the times it turns vanilla, shit or counterproductive, but you find some jewels too.

Currently testing the microdosage regimen at 4mgs/day total. Today is the first day. Some users report cognitive enhancements in a week or so. I would say its BS and I wont notice anything but I just feel like doing the test. I will report back in 7 to 10 days if the 4mgs day had not killed me
 
Hexagon Sun said:
The microdoses im talking in the previous post are 1 to 25mgs total per day, not per kilo. Pretty much everyone knows that DNP is deadly in the hands of a retarded.

I love to experiment all kind of substances and biohackings of all colors. 90% of the times it turns vanilla, shit or counterproductive, but you find some jewels too.

Currently testing the microdosage regimen at 4mgs/day total. Today is the first day. Some users report cognitive enhancements in a week or so. I would say its BS and I wont notice anything but I just feel like doing the test. I will report back in 7 to 10 days if the 4mgs day had not killed me
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Yeah -20mg/day has proven fatal. So not a microdose.
 
Fertile said:
Interesting that some makers get around the law by offering sodium dinitrophenolate.

But if anyone is taking an unknown 'fat burner' is just shows that those who take drugs as part of their physical training are by far the LEAST informed. I've been temped to buy those multidose vials and plaster any old steroid name onto them.
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I think the fatalities have all been overweight people that did not work out (or just started) and wanted to get lean fast.
Most bodybuilders have heard the dangers of it and are aware that they could die.

Fertile said:
Yeah -20mg/day has proven fatal. So not a microdose.
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Really? I had no idea that some people could be so sensitive.
Where did you read about that? Case study, news?
 
Phobos said:
I think the fatalities have all been overweight people that did not work out (or just started) and wanted to get lean fast.
Most bodybuilders have heard the dangers of it and are aware that they could die.


Really? I had no idea that some people could be so sensitive.
Where did you read about that? Case study, news?
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Case study.
 
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