In order to test those observations given above, I decided to try an experiment for myself regarding low doses on tryptamines with 5HT1a agonist activity, only with some differences
1/ As I did not have any DMT to carry out this experiment with, I used 5-methoxy DMT, which differs slightly from DMT in terms of qualitative effects, but is also a potent 5HT1a as well as 5HT2a agonist (dose adjusted accordingly). The 5-methoxy DMT was material that had been recrystallizede from methanol, then dissolved in sterile saline (actually for cats, but the same make up/osmolarity as saline for human use)
2/ As I have no experience of how to give IV doses, I have had to use the IM route. For this purpose, I used 3 times the IM dose regeime that would have been used for IV administration.
To ensure no issues with any possible tolerance, I also left at least 2 hours between doses
0.3mg (300ug equiv to 100 ug IV)
Not much happened, could feel something, but too vague not to be put down to placebo
0.75mg (750ug equiv to 250ug IV)
Definitely something, it feels quite relaxing, but not particularly psychedelic in nature, although there is a tendancy to be more concerned with inner mental processes, rather than external stimuli (other than background music)
1.5mg (equiv to 500ug IV))
Aha! This is more familiar, a certain psychedelic nature to the experience, but quite mild compared to the intense onslaught of smoked material. Still characterized by a relaxed, laid back onset of intoxication.
3.0mg (equiv to 1.0mg IV)
Pretty much more of the same as 1.5mg, except nowhere near as relaxed; even had the odd moment of feeling the onset second by second. Time dilation is noticable now
4.5mg (equiv to 1.5mg IV)
Right, that's my lot. This is characteristic of 'normal' 5-methoxy DMT onset, except that instead of the sudden 'whoosh' of the smoked experience, this was more of feeling my ego and intergrated sense of self being slowly (in comparison to smoking onset) dismantled. The onset was a much more anxious affair, and I kept finding myself partaking of stereotyped movements (leg rubbing mostly) that I recognize as being one of the things I tend to do with early stage onset anxiety of large doses of psilocybin and other oral psychedelics with a fairly rapid onset. The whole thing lasted about 45 mins, and the first 10 mins in no way resembled anything like a relaxed opiate onset. Somebody said that they'd never try snorting 5-methoxy DMT because of the uncomfortable onset; I think that this method lies somewher between smoking and snorting, but I'm not keen to repeat theis dosage and method.
It does seem to be the case that small doses have some sort of very relaxing psychological effect, similar to opiates, but I think it's most probably also got a lot to do with the MDMA type anxiety reducing effects as well.
PS. A couple of hours after the last dose, I developed a tension headache, possibly due to the subconcious anxiety generated by the two higest doses. Took 2, 500mg paracetamol tablets and 5 mg of diazepam at least 45 mins to get rid of it (just in case anyone intends to repeat the above)
