Dmmda

[Canis aureus]

Well,

interesting ccompound to say the least. It is in the class of essential amphetamines like Shulgin puts it. The corresponding essential oil is apiole from the Oil of Parsley (I won't go deeper in syntesis talk )

I lke the structure, because it reminds one of both, MDMA and mescaline! And as Shulgin puts it further effects are also very interesting -- (75 mg) "This was equal to somewhere between 75 and 100 micrograms of LSD". Dosage being from 25mg to 75 mg while Pihkal dosages are in a bit of lower side of scale. What dose would be equal to 200 micrograms of acid, if such dose would actually exist? But, maybe the potential of that drug won't go that high at all. Anyway, would be perfect one to test in some sunny day...

I forgot to say, that I like also the lustful theory of essential amphetamines, corresponding to those essential oils of course.

 

[Riemann Zeta]

Wow, this is one of those weird 4-substituent amphetamines, like tetramethoxyamphetamine. Historically, 4-substituent amphetamines just haven't been well received, as they have a considerable body load. However, considering there exist only a handful of reports on these guys, their potential is pretty much unknown.

 

[Ham-milton]

With all those other substitutents, I'm surprised it's active. It is a weirdo, for sure.

I assume that because it's so substituted it doesn't have the body load issues.

 

[Canis aureus]

I add the quotes, although everyone could take a look at Pihkal if one just wants. In commentary etc, Shulgin wrote:

DMMDA was the first of the tetraoxygenated amphetamine derivatives that was ever explored in man, back in 1962. And it is not easy to find an acceptable single phrase to describe its action or an acceptable number to describe its potency. I have put the value of 10 mescaline units (M.U.) into the literature and this would imply that maybe 30 milligrams was an active dose. This is probably too low, and some day I would like to run an experiment with the entire research group with this compound to see just what it really does.

The essential oil that corresponds to DMMDA is, of course, apiole from the Oil of Parsley, which again ties together the spice world and the amphetamine world. And there is isoapiole, also a natural thing. This pair represents the ring-substitution pattern of one of the ten essential oils and DMMDA is one of the ten essential amphetamines.

Several people have asked me what I thought about the potential activity of a compound with a methyl group added to DMMDA. One of these possibilities would be the N-methylated derivative, 2,5-dimethoxy-N-methyl-3,4-methylenedioxyamphetamine, or METHYL-DMMDA (or DMMDMA for the dimethoxy-methylenedioxy-methamphetamine nomenclature). It is a MDMA analogue, and is described in the recipe for METHYL-MMDA-2.

And in Methyl-MMDA-2, he put:

This is the only MMDA analogue that has been explored as an N-methyl derivative. A more highly substituted analogue has also been made, the N-methyl derivative of DMMDA. Isoapiole (see its preparation under DMMDA) was oxidized with formic acid and hydrogen peroxide to the ketone (2,5-dimethoxy-3,4-methylenedioxyphenylacetone, a solid with a mp of 75-76 °C from methanol) which was reductively aminated with methylamine and amalgamated aluminum to give 2,5-dimethoxy-N-methyl-3,4-methylenedioxyamphetamine hydrobromide monohydrate (METHYL-DMMDA, or DMMDMA) as a white crystalline solid with a mp of 91-92 °C. The hydrochloride salt was a hygroscopic solid. Anal. (C13H22BrNO5) C,H. The above ketone has also been used in the synthesis of another methylated DMMDA, on the beta-carbon. This is described under DMMDA itself. DMMDMA has not yet been launched into an evaluation program, and I wouldn't be surprised if the needed dosage might be up there somewhere over 100 milligrams. I feel quite sure that the answers may be known in the near future. There is a surprisingly large number of inconspicuous chemical explorers out there all over the world, doing their synthetic thing in their private laboratories. They are truly the astronauts of inner space.

I really like that last sentence.

 

[GlassAss420]

"There is a surprisingly large number of inconspicuous chemical explorers out there all over the world, doing their synthetic thing in their private laboratories. They are truly the astronauts of inner space. "

When I grow up I wanna be a chemist.. LOL.

 

[<pyridinyl_30>]

I have heard a trip report of DMMDA (from apiole) at the 50mg level that was barely threshold at best. It would not surprise me if DMMDA is orally active at the 200mg to 500mg level. I would be willing to try it at that level anyway.