Opioids Diminished euphoria from opiates

[Survival0200]

I used to love codeine when I was younger. I could get a nice high from a dose of 100 mg, and really high with 200 mg.

After some years I started taking clozapine and citalopram.

Today, when I take the same kind of doses of codeine, it really doesn't work that well. I get some effects for an hour and so, but not the same kind of glow as before.

I wonder if my medication has some kind of effect on getting diminished euphoria from opiates?

I understand clozapine is a dopamine antagonist - could it play a role here? Do you think antipsychotics generally diminish the euphoria from opiates?

Also, I think citalopram is a mild CYP2D6 inhibitor, and codeine needs this enzyme for the demethylation to morphine.

 

[GetMeOutOfThisCRAP]

I doubt that would cause this interaction. Even with very infrequent use--one does build tolerance just more slowly.

However in my opinion--whatever medication you are taking might affect your digestive system. That could delay or weaken the opioid effects I suppose. Sometimes the buzz just doesn't hit as hard without rhyme or reason. Opioids act on a very complex mechanism of action. They're not always going to work like a charm. The metabolism has to be in good working order.

But either way opiates have diminished euphoria in time anyway. Man what a terrible realization when a blue M30 glorious oxycodone felt like a joint. The effects were so mild by then.. then again I ate them daily. All opiates suck in the end. What a bunch of evil douche substances.

 

[KangKongSoup]

Those two meds will definitely diminish the euphoria.