Misc difference between dimenhydrinate and diphenhydramine?

[tttannerrr]

is dimenhydrinate more powerful than diphenhydramine? and also what are the differences between the two?

 

[sekio]

Dimenhydrinate is a compound of diphenhydramine with chlorotheophylline (basically caffeine). As such it is weaker as an antihistamine but has fewer sedative side effects.

Diphenhydramine is the stronger of the two.

 

[Thanatos]

^ are you sure it is always in conjunction with a xanthene? I thought dimenhydrinate was just a salt of diphenhydramine.

 

[sekio]

It is.

Chemically, dimenhydrinate is a salt of two drugs: diphenhydramine, and 8-chlorotheophylline, a chlorinated derivative of theophylline.

Read More

 

[allthegoodjwh's]

also i might add 50 mg dimenhydrinate contains 27.2 mg of diphenhydramine as far as comparing the two potency wise

 

[Thanatos]

How many mg's of chlorotheophylline would be in a 50 mg tablet of demenhydrinate? I can't find much info besides the equivelant dose of diphenhydramine posted above and on a few basic sites.

 

[sekio]

50 - 27.2mg, or 22.8mg

54.4% diphenhydramine
45.6% 8-chlorotheophylline

 

[Thanatos]

Do you know the dose necessary for a threshold-active dose of 8-chlorothephylline? I'm curious if it acts more as a means of keeping the combo salt non-drowsy or actively stimulating, while retaining anti-emoticon effects.

 

[sekio]

Dosage would likely be similar to caffeine.

It's added in to combat the sedation, somewhat.