Been trying to get off of this drug for about 5 months now, everytime I do I have bad thoughts of wanting to harm people so I have to go back on it. THe trouble is that I"ve gained 30 lbs on this drug, went from 220 to 250. UGH! What do I do people? Is there any antipsychotic that might ward off the bad thoughts during the withdrawal?
What are you on it for?
The withdrawal of Depakote is pretty intense. You have to taper off of it slowly just like any other med and you need to do this under the care of your psychiatrist. Depakote is a heavy duty prescription for long term use so obviously your doctor sees a need for such strong intervention.
I wouldn't take Depakote lightly. Neurontin is known to help get off of Depakote but it carries its own risk of dependence and it is not a mood stabilizer and carries a slight risk of hypomania. It also isn't commonly used for that purpose, it is normally prescribed for other reasons and carries that as an added bonus.
Out of all of the atypicals, the only one that I would ever personally recommend is Geodon (ziprasidone). Its certainly far less nasty than Depakote is. Zyprexa (olanzapine) would trigger even more weight gain than Depakote and most likely Seroquel (quetiapine) would as well. Geodon tends to be weight neutral or mildly weight positive. Some people lose weight on it.
It is definitely something to discuss with your doctor - the two of you need to come together and decide what is best. There are very few cases where long term use of Depakote is effective, let alone recommended. It can be a godsend for someone locked in mania or coming off of a huge alcohol bender where seizure risk is a strong concern but that's typically a short intervention, 1 to 3 months maximum as other drugs are less toxic and more effective for maintenance therapy.
As for the other mood stabilizers, the only one that I would recommend is Trileptal (oxcarbazepine, the big brother of Tegretol (carbamazepine) that keeps the effectiveness without the side effects and drug interactions) or possibly Lamictal (lamotrigine). I didn't like the side effects of Lamictal and you have the risk of SJS with it but it is weight neutral and for some people it is the most effective mood stabilizer around.
Topamax (topiramate) is worth a look too. It has strong mood stabilizer properties and weight loss is a very common side effect. It is commonly used for migraines but it is being used for mood stabilization more and more plus it is one of the strongest anti-seizure meds around to boot. The big issue with it is that it has a notorious reputation for making you feel stupid. We call it "Dope-a-max" around here because it really does slow you down mentally. Then again, Depakote does too.
Best of luck to you!