Opioids Decreasing Bupe's blockade with SJW

[RTrain]

So St John's Wort is suppose to be a pretty potent CYP3A4 inducer and bupe is metabolized by that enzyme. Anyone think its possible SJW will decrease the blockade effect time for bupe? There are people out there who say they use it to get a stronger agonist effect from bupe because of quicker metabolizing into norbupe. One would think if its metabolizing quicker then its going to reduce the blockade time. I have also read reports which state it has little effect on how the bupe makes you feel, but they definitely needed to redose sooner. Anyone got any thoughts on this or maybe some facts (?!?!)

 

[El Barto]

Interesting thread, it would be great to know how exactly to decrese the blockade effects of bupre

But i have a question, what do you mean with SJW? Saint Jhon who rides the dragon is the only saint jhon i know

 

[Gaz_hmmmm]

^^^
Ignore this arse here! If you have nothing to add to the thread don't bother posting!

St John's Wart/Hypericum perforatum is an MAOI. Just a warning for you RTrain but here's a quote from Erowid :-

Although early analysis indicated that St. John's Wort (Hypericum perforatum) is a MAOI,1 more recent research has shown this action to be extremely weak, and the herb's antidepressant effects can not be attributed to MAO inhibition.1 There have been no reported "adverse MAOI effects" from the combination of St. John's Wort with any of the foods or drugs commonly contraindicated when taking a MAOI. However, several chemicals found in St. John's Wort are known to activate five cytochrome P450 enzymes, and the body uses cytochrome P450 enzymes to break down most pharmaceuticals. There is strong evidence that it decreases drug levels in the blood with a number of medications, reducing their effectiveness, among other possible interactions.1

St. John's Wort's method of action on mood is still a mystery. It has been shown to increase serotonin levels, but this may be accomplished via a means that is more comparable to tricyclic antidepressants than to selective serotonin reuptake inhibitors. In any case, several herbal medical texts recommend that people avoid taking St. John's Wort in conjunction with an SSRI, due to concerns about causing serotonin syndrome. For this reason, it seems prudent to also avoid, or be extremely careful when taking, recreational drugs that strongly boost serotonin--such as MDMA, MDA, etc.--while taking St. John's Wort.

http://www.erowid.org/ask/ask.php?ID=3140

I don't know if I'd risk messing around with it. I'd advise you to definitely do alot of research into it.