Dapoxetine as a MDMA adulterant

[hamhurricane]

i know the seizures published in the DEA microgram often seem to have have little rhyme or reason (false alprazolam tablets which contain melatonin?) but i found it interesting that a recent MDMA mimic tablet contained a combination of TFMPP and Dapoxetine - for those of you unfamiliar with Dapoxetine its a SSRI with an ultra short 1.5h half life (the shortest of any SSRI?) used to treat premature ejaculation. i have never tried it, but since its a new(ish) drug i wonder if it has euphoric recreational effects?

 

[(zonk)]

^those sound like horrible pills(...i know this is of no help)

 

[seep]

I think it's safe to say no. The boolean query DAPOXETINE AND EUPHORIA turns up one Google result without an ellypsis: the result seems to be a listing of adverse effects during a dapoxetine tolerability trial (not placebo controlled) and seems to state that euphoria was reported by three of 1774 subjects.

What's more, most of the literature is rife with material like the following:

Time to ejaculation after vaginal penetration increased from less than 1 minute to more than 3 minutes. At twelve weeks, the placebo group (n = 783) averaged 1.94 minutes before ejaculation, the 30 mg dose group (n = 798) averaged 3.02 minutes and the 60 mg dose group (n = 758) averaged 3.65 minutes. Higher satisfaction levels were reported by both men and women.

Which is illuminating when you reflect on the fact that dapoxetine was initially intended to be an antidepressant. Nobody seems to even see it as worthwhile to examine the psychotropic effects.

It surprises me a little that there's hardly any mention of sexual side effects regarding this drug (e.g. erection problems or diminished sensation)--but I don't know much about it.

The FDA gave the maker a Not-Approvable Letter in 2005. Maybe there's something there.

 

[hamhurricane]

^^^
wow what an astoundingly shitty medication i cant imagine 3.65 minutes being that satisfying for either party is that really the best big pharma's master chemists can muster? i would imagine (low dose)DXM, Kratom or even two beers would be more effective.

so i wonder why they were mixing Dapoxetine into the tablets - are any of the psychoactive piperazines PDEx inhibitors as well? i ask because sildenafil and co. are pips (i doubt its been studied but perhaps one of the SAR luminaries could hazard a guess) if they are, maybe the intention was not MDMAmimesis but rather a sexual enhancement pill...

 

[fastandbulbous]

It surprises me a little that there's hardly any mention of sexual side effects regarding this drug (e.g. erection problems or diminished sensation)--but I don't know much about it.

Why not market the other SSRI's as treatment for premature ejaculation after all with paroxetine the time to ejaculation after vaginal penetration would go from under a minute to 5 weeks (if you can get an erection in the first place)!

Best inhibitor I've come across (no pun intended) is desoxypipradrol - managed about 6 hours before the big moment (for which ~I was mighty grateful as I'd been trying for the last 5 hours)

 

[Holy_cow]

I've tried Dapoxetine. Can't remember the dose, it was long ago, but I'm certain it was an active dose. No euphoria and no recreational effects. Didn't try sex while on it.

There is a plant growing in the forrests around here. It has pretty flowers early in spring and an underground bulb. Ingesting a relatively small amount of the dried bulb has exactly the effects Dapoxetine is supposed to have.

 

[dread]

I recently had a blowjob while on MDPV. I didn't time it but it surely was longer than 3.65 minutes....

 

[(zonk)]

they'll put anything in an e-pill these days

 

[Voltech]

Actually it's very dificult to buy Dapoxetine online. Prilligy is dispensed only by pharms.


But there are 1 website who sells this pills (very cheap). The Seller says each pill contains 100mg Sildenafil and 60mg. Dapoxetine. (they are in rhombus form, and a strange green colour)

We lab-analized one of this pills, They didn' contain Sildenafil, only dapoxetine, and less cuantity than 60mg. The GC/MS shows a very clean peak.

I tried one and the have no euphoric recreational effects. You can sleep, and didn't note anithing strange.

Maybe people sell it as Fake pill, but not as adulterant.

Mix Dapoxetine( SSRI) with MDMA is dangerous. you can get a serotonin syndrome.

 

[Coolio]

Best inhibitor I've come across (no pun intended) is desoxypipradrol - managed about 6 hours before the big moment (for which ~I was mighty grateful as I'd been trying for the last 5 hours)

Weird. Just tried desoxy again for the first time in years recently; before I used it for focusing on work, I felt compelled to wank and it didn't take hardly any time at all.

 

[seep]

Mix Dapoxetine( SSRI) with MDMA is dangerous. you can get a serotonin syndrome.

Wasn't this debunked by Fire?

To the Editor of the New England Journal of Medicine:

In their article discussing online drug information resources, Boyer et al. express concern over a comment made on Erowid.org that taking an SSRI after Ecstasy may reduce the risk of MDMA neurotoxicity.1 They state that taking an SSRI after MDMA might lead to serotonin syndrome, but their concern is unsubstantiated.

SSRI coadministration has been practiced by MDMA users for many years, without evidence of serotonin syndrome, as documented by published papers2 and dozens of unpublished reports collected by Erowid. Additionally, one clinical study administered 1.5 mg/kg MDMA (po) after citalopram with no evidence of increased medical risk (3). By blocking MDMA interactions with the serotonin transporter, SSRIs reduce the physiological and experiential effects of MDMA in humans2,3 and neurotoxicity in rodents.4 This includes attenuation of both heart rate and blood pressure increases.

No drug or drug combination is without risks. At least one adverse event (not involving serotonin syndrome) has been reported after this combination.5 Attempting to decrease risk of MDMA neurotoxicity with an SSRI may increase other risks, but serotonin syndrome is not known to be one of them.

The well meaning but misinformed concerns of Boyer et al. illustrate why many people rely on Erowid.org and other alternative information sources rather than biased "anti-drug" or government-sponsored sites. Unlike those sources, the Erowid.org archive maintains reliability through literature reviews, expert critiques, interviews with users and input from readers. We welcome comments and corrections.

1. Boyer EW, Shannon M, Hibberd PL. 2001. Web Sites with Misinformation about Illicit Drugs. N Engl J Med 345:469-471.
2. Stein DJ, Rink J. 1999. Effects of ‘Ecstasy' blocked by serotonin reuptake inhibitors. J Clin Psychiatry 60:485.
3. Liechti ME, Vollenweider FX. 2000. The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine (‘Ecstasy') in healthy volunteers. J Psychopharmacol 14:269-74.
4. Shankaran M, Yamamoto BK, Gudelsky GA. 1999. Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. Eur J Pharmacol 385:103-10.
5. Lauerma H, Wuorela M, Halme M. 1998. Interaction of serotonin reuptake inhibitor and 3,4-methylenedioxymethamphetamine? Biol Psychiatry 43:929

 

[Voltech]

Personally I havn't tried to mix dapoxetine with MDMA, because MDMA acts like a ejaculation delayer by it self.

The first time I tried dapox I've take before amph+GHB+Mephedrone. and I didn't feel nothing unusual.