Could Tylenol (acetaminophen) inhibit the metabolism of melanotan 2, causing side effects?

JohnBoy2000

JohnBoy2000

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It's the only explanation I can think of.

In 2022 I dosed mt2 heavily as I do every year, no problem.

At the end of 2022 through 2023 I had to start dosing between 2 and 4 tablets of tylenol every day (about 2 grams on average).

Which is known to be toxic to the liver, perhaps inhibiting certain enzyme activity, and other liver function?

Well, first I developed an intolerance to retinoids (tretinoin).

Then in summer 2023 I dosed mt2 as usual, and on the third day developed an significant increase in my tinnitus, and SHARP mood fluctuation (depression).

These are listed side effects of mt1 on the fda data site, but I had never experienced them previously.

Only explanation I have is, the daily Tylenol use inhibited metabolism of the aforementioned, cause side effect emergence.

Thoughts on this as a possibility?
 
Ever drink that stuff I'm on a high dose of acetaminophen right now!
 
I have been taking 4 grams of paracetamol /day for 20+ years, with opioids, benzos, antiepileptics and more. I use a vial of Melanotan 2 every spring, I haven't noticed anything but the tan and the liver bloodwork is perfect.
 
JohnBoy2000 said:
It's the only explanation I can think of.

In 2022 I dosed mt2 heavily as I do every year, no problem.

At the end of 2022 through 2023 I had to start dosing between 2 and 4 tablets of tylenol every day (about 2 grams on average).

Which is known to be toxic to the liver, perhaps inhibiting certain enzyme activity, and other liver function?

Well, first I developed an intolerance to retinoids (tretinoin).

Then in summer 2023 I dosed mt2 as usual, and on the third day developed an significant increase in my tinnitus, and SHARP mood fluctuation (depression).

These are listed side effects of mt1 on the fda data site, but I had never experienced them previously.

Only explanation I have is, the daily Tylenol use inhibited metabolism of the aforementioned, cause side effect emergence.

Thoughts on this as a possibility?
Click to expand...
I would lean more towards the quality of your Grey market goods that are being manufactured without quality control over Tylenol potentiating the effects of drugs.
 
Psykoton said:
I have been taking 4 grams of paracetamol /day for 20+ years, with opioids, benzos, antiepileptics and more. I use a vial of Melanotan 2 every spring, I haven't noticed anything but the tan and the liver bloodwork is perfect.
Click to expand...

May I ask what condition you're using the acetaminophen for?

No issues with hearing or tinnitus or anything?

Mind me asking, do you still have all your hair? Curious how its effect on liver function effects skin/hair health also.
 
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They shouldn't interact. Melanotan is going to get degraded to its component amino acids in the proteasome. This is going to occur outside of the liver and won't engage any of the cytochrome p450 enzymes involved in oxidative metabolism.

Tylenol doesn't induce/inhibit liver enzymes. It's toxicity comes from oxidative metabolism to the electrophile, NAPQi. This is reactive enough that it only attacks proteins in the liver (as it isn't stable enough to be transported elsewhere in the body). The subsequent liver damage is hard to forecast, as the majority of the damage occurs when your body sees liver protein-NAPQI addicts as foreign and begins to kill cells containing that adduct. The immune involvement means that this damage is not strictly dose-dependant.

I would expect your negative effects to be coming from hormonal issues, rather than a pharmacokinetic drug-drug interaction.

When we take drugs we alter ourselves. Too often people are surprised when drugs that they have tolerated well, are now problematic. Physiology is dynamic.
 
Skorpio said:
They shouldn't interact. Melanotan is going to get degraded to its component amino acids in the proteasome. This is going to occur outside of the liver and won't engage any of the cytochrome p450 enzymes involved in oxidative metabolism.

Tylenol doesn't induce/inhibit liver enzymes. It's toxicity comes from oxidative metabolism to the electrophile, NAPQi. This is reactive enough that it only attacks proteins in the liver (as it isn't stable enough to be transported elsewhere in the body). The subsequent liver damage is hard to forecast, as the majority of the damage occurs when your body sees liver protein-NAPQI addicts as foreign and begins to kill cells containing that adduct. The immune involvement means that this damage is not strictly dose-dependant.

I would expect your negative effects to be coming from hormonal issues, rather than a pharmacokinetic drug-drug interaction.

When we take drugs we alter ourselves. Too often people are surprised when drugs that they have tolerated well, are now problematic. Physiology is dynamic.
Click to expand...
Agreed. Should be no interaction. Those sound like regular melanotan sides to me.
 
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