BilZ0r
Bluelight Crew
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A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice.
Escobedo I, O'shea E, Orio L, Sanchez V, Segura M, de la Torre R, Farre M, Green AR, Colado MI.
Departamento Farmacologia, Facultad Medicina, Universidad Complutense, 28040 Madrid, Spain
Br J Pharmacol. 2005 Jan;144(2):231-241.
PDF Available Free
What he have here is essentially another paper trying to show us that central, direct into the brain, administartion of MDMA is not neurotoxic, and again, we have a methodological flaw, which stops them from making that conclusion.
I won't go through all the figures, just the important ones. Basically the experiment goes: Inject mice with 30mg/kg three times, at 3 hour intervals, or directly inject MDMA into the striatum, 1, 10 or 100 µg once. Then measure rectal temperature, and dopamine and serotonin content in the brain either 1 hour or 7 days after final dosing.
So the results.. as you would expect a reduction in striatal dopamine, and general brain serotonin content in the brain after IP injection, but not after direct injection into the striatum 1 hour after dosage.
And similar results 7 days after dosing, except here you don't get long term serotonin damage, just dopamine damage, but again, only after peripheral dosage, not central injection.
So, the toxic metabolite crowd is just about to strike one up for themselves, as it says in the abstract "This indicates that the long-term effect is not attributable to the parent compound [MDMA]". BUT, they measured the rectal temperature, and, as you would expect, knowing the importances of peripheral serotonin receptors in MDMA-induced hyperthermia (which the neurotoxicity is dependent on), DIRECT INJECTION OF MDMA INTO THE BRAIN DOES NOT PRODUCE HYPERTHERMIA
So while it is, prima facie, legitamate to say direct injections of MDMA do not cause neurotoxicity, it is completely invalid of them to then conclude that under normal circumstances MDMA in the brain isn't neurotoxic in itself, or more, that peripheral MDMA metabolism is needed to cause neurotoxicity.
Escobedo I, O'shea E, Orio L, Sanchez V, Segura M, de la Torre R, Farre M, Green AR, Colado MI.
Departamento Farmacologia, Facultad Medicina, Universidad Complutense, 28040 Madrid, Spain
Br J Pharmacol. 2005 Jan;144(2):231-241.
PDF Available Free
What he have here is essentially another paper trying to show us that central, direct into the brain, administartion of MDMA is not neurotoxic, and again, we have a methodological flaw, which stops them from making that conclusion.
I won't go through all the figures, just the important ones. Basically the experiment goes: Inject mice with 30mg/kg three times, at 3 hour intervals, or directly inject MDMA into the striatum, 1, 10 or 100 µg once. Then measure rectal temperature, and dopamine and serotonin content in the brain either 1 hour or 7 days after final dosing.
So the results.. as you would expect a reduction in striatal dopamine, and general brain serotonin content in the brain after IP injection, but not after direct injection into the striatum 1 hour after dosage.
And similar results 7 days after dosing, except here you don't get long term serotonin damage, just dopamine damage, but again, only after peripheral dosage, not central injection.
So, the toxic metabolite crowd is just about to strike one up for themselves, as it says in the abstract "This indicates that the long-term effect is not attributable to the parent compound [MDMA]". BUT, they measured the rectal temperature, and, as you would expect, knowing the importances of peripheral serotonin receptors in MDMA-induced hyperthermia (which the neurotoxicity is dependent on), DIRECT INJECTION OF MDMA INTO THE BRAIN DOES NOT PRODUCE HYPERTHERMIA
So while it is, prima facie, legitamate to say direct injections of MDMA do not cause neurotoxicity, it is completely invalid of them to then conclude that under normal circumstances MDMA in the brain isn't neurotoxic in itself, or more, that peripheral MDMA metabolism is needed to cause neurotoxicity.
