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Combining Psilocybin and Mescaline. Anyone done it?

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MetanoiaMan

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WAs reading and article about original palo alto psychedelic experiments in the sixties. Mixed Psilocybin and Mescaline. I have both and have used them separately. Wondering if anybody has ever combined them and what their experience was?
 
I've mixxed cactus tea resin with shrooms. Best combo ever, always eat my shrooms and cactus about the same time. Right as soon as you start peaking on shrooms the cactus will start to kick in (cactus tends to be really sneaky onset at an hour and a half for me.) This combo will make you super lethargic with a nice fuzzy body buzz, has some of the most wonderful flowing visuals as well.
Another reason this rocks is because if i go all the way with mushrooms i feel like demon entities are spying on me, if i go all the way with cactus i puke my guts out. This combo allows me to trip face without puking or fearing for my sanity.
I have a couple of foot worth of cactus resin and a mushroom chocolate that i've been saving for the right time. Best for a solo trip im my opinion, it's a very gentle combo that should be enjoyed with nature.
The downside to this combo is bloating from eating dried mushrooms and cactus extract. Best to consume these on an empty stomach, once i ate them after a large meal and i looked pregnant from all the trapped gas. Peppermint tea will help unplug with the quickness and gives very relieving and entertaining mega-farts.
My suggestion is DO IT
 
I could definitely see some synergy going on there, but it also sounds like a recipe for Nuclear Powered Puking™. Make sure to report back if you do it!
 
Nothing intresting in this combo: between the waves of tryptamine you will feel waves of phenethylamines. Was like a fighting between them. Than phenetylamines wins and you do not feel any triptamine at all. Just the waste of mushrooms.
 
Wutang_Forever said:
I've mixxed cactus tea resin with shrooms. Best combo ever, always eat my shrooms and cactus about the same time. Right as soon as you start peaking on shrooms the cactus will start to kick in (cactus tends to be really sneaky onset at an hour and a half for me.) This combo will make you super lethargic with a nice fuzzy body buzz, has some of the most wonderful flowing visuals as well.
Another reason this rocks is because if i go all the way with mushrooms i feel like demon entities are spying on me, if i go all the way with cactus i puke my guts out. This combo allows me to trip face without puking or fearing for my sanity.
I have a couple of foot worth of cactus resin and a mushroom chocolate that i've been saving for the right time. Best for a solo trip im my opinion, it's a very gentle combo that should be enjoyed with nature.
The downside to this combo is bloating from eating dried mushrooms and cactus extract. Best to consume these on an empty stomach, once i ate them after a large meal and i looked pregnant from all the trapped gas. Peppermint tea will help unplug with the quickness and gives very relieving and entertaining mega-farts.
My suggestion is DO IT
Click to expand...
I dig your enthusiasm. i have mushrooms that I've encapsulated and achuma resin. So, I'm thinking it will go down easy....
 
IamMe90 said:
I could definitely see some synergy going on there, but it also sounds like a recipe for Nuclear Powered Puking™. Make sure to report back if you do it!
Click to expand...


It was awesome. I went low dose with each and it was mellow and beautiuful. Figured it was better to do too little than too much. I hung out around the house feeling warm and open and then rode down to Venice Beach on my bike and felt the air going by and saw the sun shining on the water in the holiest of ways. It's warm, easy and compatible. Highly Recommended.
 
Ayahuasca is similar to shrooms (alternate name for psilocybin is 4-PO-DMT):

Moreover, there is circumstantial evidence for traditional use of ayahuasca containing mescaline and/or other B-phenethylamines in Amazonian Peru. One of the most complete scientific studies of ayahuasca yet conducted reported the use by Peruvian Indians of a cultivated Opuntia species, called tchai in Sharanahua, as an ayahuasca admixture, and said to be "very strong."[ * ] Another cactus, a species of Epiphyllum, known as pokere in Sharanahua and wamapanako in Culina, was likewise added to ayahuasca.(15) A Shipibo informant recently stated that tchai was no longer employed in ayahuasca, the resulting brew becoming too intense.(16) We have no phytochemical data on these cacti, but several species of Opuntia are known to contain low levels of mescaline, (17) and preliminary human bioassays suggest that the B-carboline harmaline might in fact potentiate mescaline - low doses of 60 and 100 mg mescaline hydrochloride, corresponding to 51 and 86 mg base or 0.78 and 1.32 mg/kg respectively, were decidedly psychoactive. The combination of mescaline or mescaline-containing cacti with B-carbolines has been dubbed peyohuasca.(5,18)

15. Rivier, L. and J.-E. Lindgren (1972). 'Ayahuasca,' the South American hallucinogenic drink: An ethnobotanical and chemical investigation. Economic Botany. 26(1):101-129.

16. Bianchi, A. and G. Samorini (1993). Plants in association with ayahuasca. Jahrbuch fur Ethnomedizin und BewuBtseinsforschung. 2:21-42.

17. Ott, J. (1993). Pharmacotheon: Entheogenic Drugs, Their Plant Sources and History. Natural Products Co., Kennewick, WA.

18. Ott, J. (1994). The Age of Entheogens & The Angels' Dictionary. Natural Products Co., Kennewick, WA.

5. Ott, J. (1994). Ayahuasca Analogues: Pangean Entheogens. Natural Products Co., Kennewick, WA.

Jonathan Ott. Pharmahuasca: On Phenethylamines and Potentiation. MAPS newsletter, Volume 6, Number 3, Summer 1996, 32-34

*B. N. Meyer, Y. A. H. Mohamed, and J. L. McLaughlin, ‘β-Phenethylamines from the cactus genus Opuntia’, Phytochemistry, vol. 19, no. 4, pp. 719–720, Jan. 1980


I dont recommend adding Syrian Rue to San Pedro for a better San Pedro experience because I dont think it makes it better. I think it makes it harder to hear San Pedro and makes the experience a little harsher. I do recommend Ayahuasca brews with t'chai - I think its a pretty nice mix and it does enhance it a little bit (not a huge difference, but a mild addition that is nice). I think it makes it easier to to talk to Ayahuasca and makes the experience a little more positive leaning and lovey dovey feeling.

MapachoCura, Feb 16, 2024, reddit

I never ignored that harmine/harmala has mild psychedelic properties on its own (I wrote articles and published a book about working with vine only brews many years ago so am well aware). I never said it doesnt. I just said I dont find mixing MAOI's with San Pedro to be beneficial or worthwhile - San Pedro is better on its own. Mixing more things doesnt always make it better, sometimes it detracts or just isnt very noticeable etc. In this case, you will be slightly higher but not much, but San Pedro doesnt seem to like the mix and talks to people way less. Also increased nausea and body load for no added benefits.

MapachoCura, Feb 14, 2024, reddit
 
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