Harm Reduction Combining depressants

[Ninae]

I was wondering what are the most dangerous depressants to combine.

I mostly just use depressants and have slipped into a coma many times, from compulsively redosing after benzo amnesia has set in. I rarely combine with alcohol, which I know is most dangerous. But would anyone be able to make a list of what are the most depressing drugs/most dangerous to combine?

Like, I know benzos and opiates is the classic dangerous combination, though less sure about what amounts are dangerous. But what about other depressants, like, say, Lyrica, or Soma. Would Lyrica be more depressing to the nervous system than benzos (as it sure knocks you out harder)? Also, MXE I know is slightly depressing, but a stimulant as well, so I'm guessing not that dangerous. Anyway, some safety guidelines would be appreciated.

 

[NeighborhoodThreat]

It's not as cut and dry as you may think. A lot has to do with dosing and individual tolerance, as well as the time frame that you're taking the drugs in question during.

Barbiturates, alcohol, GHB (and related drugs GBL, 1,4-Butanediol) are historically the most potent depressants out there, GABA depressants anyway. There are some opiates and opioids that will kill you if you mixed them with even very low doses of benzos, again, for a non-tolerant person. For example, combining fentanyl (and its analogs), buprenorphine or methadone with benzos or other depressants is very dangerous.

I'd say mixing barbiturates with basically anything is the most dangerous. Barbiturates and alcohol has killed plenty of people. Benzodiazepines are more "forgiving" when it comes to mixing with other depressants, but it is still quite dangerous. Soma is another depressant that is dangerous to mix with benzos, alcohol, opiates, etc. All depressants are dangerous when mixed together. How dangerous depends on many, many factors, as I've said before.

Again, it is very difficult to answer your question because of how vague it is.

 

[Ninae]

I know its not that simple and people can get very different results from taking the same doses, etc. that's why I wanted to ask. Apart from type of drugs I was also wondering what size doses are dangerous to mix, like how many benzos you can safely take with how much alcohol, for instance. Also how dangerous are weak opiates like Codeine or UEI (don't know which would be the strongest) to mix with other downers.

 

[Moe-D]

Lyrica might be kinda bad :/ especially in big doses, since it gets kinda strange on it's own already.
But I've mixed Lyrica with opioids, bupre and methadone to name couple, but rly dont go above 600mg if you decide to mix..
And pop those pill's patiently if your high on opi's already!! Cause your feeling good already, and adding too much can be kinda... ass..

 

[Ninae]

Yea, Lyrica must be much worse than Gabapentin. What about Seroquel though? Is that also a dangerous depressant to add into the mix?

 

[NeighborhoodThreat]

Once again, we don't know what "mix" you're talking about here.

 

[Moe-D]

Ive mixed it with bupe.. Doesnt get any better or potentiate euphoricly maby makes you more "noddy". But im pretty sure it is dangerous

 

[NeighborhoodThreat]

I've mixed Seroquel with a few different opiates (low doses of Seroquel, never anything higher than 50mg) and it really just acts like a super powerful antihistamine (very sedating - lots more "nod" as Moe-D mentions).

As far as mixing Seroquel, an opioid/opiate and another depressant goes...I wouldn't do it. It is more dangerous.

 

[Ninae]

What about other things you might not think of, but just take for sleep, like Phenibut and Niacin?