Yeah, we are usually ANTI-DRUG SYNTH stuff here, but I want Roches input on this well-known synth:
==BEGIN==
HYDROXYCODEINONE: The same product obtained from the 30% hydrogen peroxide treatment of thebaine in acetic acid can also be obtained directly from codeine.
30 grams of codeine in 80ml water with 25grams acetic acid, is treated cold with a solution of 20grams sodium dichromate in 25ml water. An oily precipitate forms which becomes crystal after short warming. The mixture is heated to 80deg with stirring until all the solid goes into solution; the temperature rises spontateously to 90deg. After short standing, the base is precipitated from the cold solution as the dichromate by adding an excess of chromic acid solution. Crystallize from alcohol with a little chloroform as plates, decomposes at 275deg. Stable to strong acid or alkali. Soluble in chloroform, ethyl acetate, ligroin. Sparingly in alcohol, insoluble in ether or water.
Simple hydrogenation over Pt, Pd, or Ni would satutate the recovered and purified compound to the potent dihydro version. Hydrogenation over Pt or Pd in dilute acetic acid give 93% to 97% yields. This product would be 14-hydroxydihydrocodeinone or Oxycodone, either as the dichromate or possibly acetyl salt.
==END==
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