Codeine & its potention, can we clarify the difference with it & other opiates

[Levvytation]

Codeine & its potention, can we clarify the difference with it & other opiates

One of the hardest facts to find on this forum is this:

Should you take your various potentitors' (Tagamet, GFJ, promethazine, diphenhydramine) before/with the codeine, or wait till its effects have kicked in.

There seems to be no definite yea or nay as far as I can see....one school of thought says codeine (uniquely?) is a 'pro-drug' and needs to be metabolised by the liver to become morphine, therefore the above potentiators prevent/reduce the codeine's disired effect. Others say different.

There are experts here, come on!

 

[Mr Blonde]

Diphenhydramine you can take before hand.

Promethazine take during, it inhibits CYP2D6 which is what converts codeine to morphine.

Tagamet and grapefruit juice need to be taken before an opioid to prevent metabolism, but will reduce the amount of codeine converted into morphine.

As far as different schools of thought... the majority of effects come from codeine being converted into morphine. Some people believe codeine-6-glucorinide may have an effect too but I have seen no evidence indicating it is euphoric or anything, there is no idea how potent it is and if enough of the codeine is converted into it for effect.

 

[nekointheclouds]

Diphenhydramine you can take before hand.

Promethazine take during, it inhibits CYP2D6 which is what converts codeine to morphine.

Tagamet and grapefruit juice need to be taken before an opioid to prevent metabolism, but will reduce the amount of codeine converted into morphine.

As far as different schools of thought... the majority of effects come from codeine being converted into morphine. Some people believe codeine-6-glucorinide may have an effect too but I have seen no evidence indicating it is euphoric or anything, there is no idea how potent it is and if enough of the codeine is converted into it for effect.

Tagamet and GFJ effect different enzymes. GFJ does NOT effect the CYP2D6 enzyme. Check out this thread:

http://www.bluelight.ru/vb/showthread.php?t=171335

 

[Naggers]

This doesn't really answer your question, but it might help in some way:

Chart of CYP450 substrates, inhibitors and inducers.

 

[psychomimetic]

Diphenhydramine you can take before hand.

Promethazine take during, it inhibits CYP2D6 which is what converts codeine to morphine.

Tagamet and grapefruit juice need to be taken before an opioid to prevent metabolism, but will reduce the amount of codeine converted into morphine.

As far as different schools of thought... the majority of effects come from codeine being converted into morphine. Some people believe codeine-6-glucorinide may have an effect too but I have seen no evidence indicating it is euphoric or anything, there is no idea how potent it is and if enough of the codeine is converted into it for effect.

Diphenhydramine is also a CYP2D6 inhibitor.

 

[Shambles]

I find GFJ potentiates codeine (and DHC) quite significantly. No idea about any of the others though. Only other things I've used to potentiate were accidental discoveries - namely tramadol and GBL. The latter in particular is extremely effective at potentiating to the point of being dangerous. Doses need to be significantly reduced until you adjust to the combo... to be honest, I'd have to warn against that one unless you're very careful cos even as a long-term heavy user of both that combo nearly finished me off when I combined them with no idea they would interact.

 

[Psychedelic Jay]

Inducers are best in ever way.

This is what I mean: Inhibitors make them metabolize slower simply because once you have blocked off one enzyme that makes a less potent metabolite, you have flooded the other one, and you are still making the exact same amount of the most active metabolite, meaning you have extended and not heighten the high in any way.

Inducers are increasing the amount of these enzymes, leading to most times double to triple the amount being converted to more active metabolites, leading to a very intense high.

Phenobarbital is the best inducing potentator, and one of the longest lasting for many applications.

 

[Levvytation]

Promethazine take during, it inhibits CYP2D6 which is what converts codeine to morphine.

Right thanks.

this is what has been confusing me (& others I'm guessing)

I take it though you mean that this inhibiting action of the promethazine on CYP2D6 doesn't waste any codeine right? What happens to the codeine
that would have been metabolised into morphine by the liver but never made it because of the promethazine?

 

[Psychedelic Jay]

It's slowed down tremendously.