More reference levels for pure cocaine.
Nasal B.A. 20-30%.
Smoked B.A. 5-30%
Oral B.A. maybe 10%?
IV is of course 100% bioavailiable
General purpose stimulant as derived from coca tea: 200mg/day maximum (orally mind you, which is less effective than nasal) ... blood levels likely don't exceed 5mg ... this corresponds to about 20mg or a "bump" every 3-4h.
"Average street dose" 20-50mg intranasal
Lethal dose approx. 1200mg.
The implication here of course is that with good coke you shouldn't need a lot. It also shouldn't make your whole fucking face numb, and shouldn't last more than maybe 45 minutes, tops.
I have a vague recollection that 30mg of intravenous cocaine hydrochloride is rather a lot, so a "dose" is likely going to be anywhere from 50 milligrams up for most people to start with (assuming good quality pure shit)
Really you should try to limit yourself to ~200mg a rail, and probably no more than a gram in a night. But this is of course going to vary with genetics, personal tolerance, and purity of your shit
Slow titration upwards is the best though. Start with a little knife-tip and see how long it goes for, and how it makes you feel. Increase dosage as needed.
Note: Many of cocaine's systemic adverse effects are due to excessive sympathetic activity {10} {19} and may be caused by rapid absorption, {13} {19} decreased patient tolerance, {01} or, rarely, {19} hypersensitivity. {01} {19} Toxic reactions are relatively uncommon with appropriate use of usual clinical doses.
The fatal dose of cocaine has been reported to be 1.2 grams. However, patient sensitivity to the effects of the medication is highly variable; adverse effects have been reported with as little as 20 mg. {01} {02} {05}
Acute toxicity may occur very rapidly. {01} {12} {19} Manifestations of systemic cocaine toxicity may occur in 3 stages (early stimulation, advanced stimulation, and depression). Although many of the signs and symptoms of early stimulation would not necessarily require medical intervention under other circumstances, their occurrence following use of cocaine indicates that prompt action is required, because progression from one stage of toxicity to the next may be very rapid. {13} {19}
The following side/adverse effects have been selected on the basis of their potential clinical significance (possible signs and symptoms in parentheses where appropriate)—not necessarily inclusive:
Yes, like, a pin head.
I mean, god forbid you think you got heroin, but ended up with fucking a fucking fentanyl analogue..