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Cocaine Cocaine harder than amphetamine?

N

Noctis

Bluelighter
Joined
Oct 25, 2009
Messages
67
from a recreational point of view, which causes more permanent changes to the dopaminergic system relative to casual use. Blowing a few lines of uncorrupted cocaine (acts on the reuptake of dopamine by inhibiting dopamine active transport), or a medicinal dose of adderall/amphetamine salts (the meth precursors method of action causing dopamine receptors to produce more of the neurotransmitter). this isn't a poll of cardio health, but of downregulation damage.
 
amphetamines(esp.meth) tend to be harder on the brain, but like what captain heroin said, frequency of use is a big factor on damage.
 
hypothetically
a half gram of mildly adulterated street cocaine (consider the standard common in your radius) over one night
or
40 mg of amphetamine salts over one night
 
yea in my experience I believe amphetamines would be the more damaging substance.

One of my theories is that cocaine is a naturally occuring alkaloid in the coca plant whereas amphetamines do not occur naturally in any form(atleast not that I know of)....therefore, they would be more likely to cause harm. Doesnt our brain have thousands of neurological receptors for different naturally occuring chemicals/molecules to be inserted into them, suggesting that humans developed with these natural chemicals playing atleast some sort of role during our evolution? I believe that this is true with opiates in some way....I am horrible at explaining this because I dont really understand it all that well, but im sure ive read of it many places before.

And since amphetamines dont occur naturally, maybe they dont quite fit into our brains receptors in as healthy a way as other natural chemicas do??...maybe???

I dont know, its just a loosely based theory, maybe someone else can shed some light on what im trying to get at.

*But yes, the amount of a drug being used plays a huge role in this as well. In my opinion though, a certain amount of cocaine will be less damaging to our brains and bodies than an equal amount of amphetamines.
 
Noctis said:
hypothetically
a half gram of mildly adulterated street cocaine (consider the standard common in your radius) over one night
or
40 mg of amphetamine salts over one night
Click to expand...

40mg of amphetamine salts (i.e. adderall) is probably better for you than a half gram of cocaine. This is just my gut instinct, I don't want to definitively say one way or the other.

jamesBrown said:
yea in my experience I believe amphetamines would be the more damaging substance.

One of my theories is that cocaine is a naturally occuring alkaloid in the coca plant whereas amphetamines do not occur naturally in any form(atleast not that I know of)....therefore, they would be more likely to cause harm.
Click to expand...

That's not something you can really go off of, there are plenty of synthetic drugs that are much safer than the tropane alkaloids found in Datura.
 
Captain.Heroin said:
40mg of amphetamine salts (i.e. adderall) is probably better for you than a half gram of cocaine. This is just my gut instinct, I don't want to definitively say one way or the other.



That's not something you can really go off of, there are plenty of synthetic drugs that are much safer than the tropane alkaloids found in Datura.
Click to expand...

Yes I am fully aware of that, but it still doesnt mean that in this particular situation, it could be a factor.

The alkaloids found in datura could simply be alkaloids which humans did not evolve to "co-exist" with in a positive way...so to speak.

But, I do agree with you that my theory is definitely not something anyone should take as fact.....I was simply wondering outloud using vague recollections to guide me.

Sorry if I caused any harm....and please dont take my posts in this thread too seriously....allthough I do think there are some things that I have spoken of that are worth looking into.
 
Wiki:

"Cocaine binds directly to the DAT1 transporter, inhibiting reuptake with more efficacy than amphetamines which phosphorylate it causing internalization; instead primarily releasing DAT (which cocaine does not do) and only inhibiting its reuptake as a secondary, and much more minor, mode of action than cocaine and in another manner: from the opposite conformation/orientation to DAT."

I think binding to the DAT1 is safer than phosphorlyting DAT1 and entering dopamine vesicles and forcing dopamine out. Cocaine wins my vote for safer drug.
 
rollingstoned! said:
Wiki:

"Cocaine binds directly to the DAT1 transporter, inhibiting reuptake with more efficacy than amphetamines which phosphorylate it causing internalization; instead primarily releasing DAT (which cocaine does not do) and only inhibiting its reuptake as a secondary, and much more minor, mode of action than cocaine and in another manner: from the opposite conformation/orientation to DAT."

I think binding to the DAT1 is safer than phosphorlyting DAT1 and entering dopamine vesicles and forcing dopamine out. Cocaine wins my vote for safer drug.
Click to expand...

Am I wrong, or does this post somewhat support my theory that I had stated earlier??
 
Soap MacTavish said:
The whole problem would be finding that unadulterated cocaine, which is as gone as the 80's.
Click to expand...

HA...thats true in some way....but, some adulterants cause very minor damage(lots of times less damage than the coke itself) therefore it could be assumed that the OP was talking about a half gram of average cocaine adulterated with typical non-threatening substance(s) compared to adderal.

Its still possible to make a comparison even though one or both of the substances isnt pure.
 
The good coke is around...scarce but there. At least in thses parts. Costs a bit more though.
 
Mm with all the cuts in most cocaine you find these days that adds some form of damage. But as someone else said cocaine is just stopping the reuptake instead of forcing more dopamine out of the neurotransmitter and such. But a dose of say 40mg adderall and half gram street cocaine , come on now i would definitely say the cocaine is doing more damage.
 
So here's my ? In all this. Cocaines action on dopamine, is more closely related to the action of Ritalin and such. Whereas amphetemine is the opposite (such as mixing the 2 wuld cause a block on the action of amp). So my guess is that amp is more harmful on dopamine than cocc is. & in my experience, a night of redosing on amps vs a nite of redosing cocaine the amp is more harmful and causes way more lasting side effects, tho in a binge you become "geeked" alot sooner than in an amp binge (maybe because the amp acts alot longer than a dose of cocc does). Your theory on coexisting with the natural alkaloids vs man mades very interesting but after a few generations of using man made chems wuldnt the body adapt to coexist just the same as the natural ones? Also those natural alkaloids didn't exist rlly in Europe and such like they did in native peoples in SA and the such. So really people of European descent would have about the same tolerance to each. Just speculation of course, it is 0430hrs n I am sober and still awake so I didn't bring my A game lol
 
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