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Cocaine Analogs

stolpioni

Bluelighter
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Apr 1, 2009
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These are four analogs I've found that seems to have very similar
stimulating effects to cocaine.
Now, I was hoping somebody could explain a little more in detail about these,
and I was hoping someone might have tried any of these compunds and
can write about their experiences.

Dichloropane
(in contrast to the closely related RTI-112, dichloropane is a potent stimulant drug which produces similar effects to cocaine in animal studies, although with a slower onset and longer duration of action.)

Butyltolylquinuclidine
(2-Butyl-3-(p-tolyl)quinuclidine (BTQ) is a stimulant DRI.[1] It is one of a number of substituted quinuclidine derivatives developed as potential medications for the treatment of cocaine abuse,[2] and produces similar effects to cocaine in animal studies, although milder and longer lasting.)

Troparil
(Troparil is documented to be a few times more potent than cocaine as a dopamine reuptake inhibitor,[1] but is less potent as a serotonin reuptake inhibitor,[2] and has a duration spanning a few times longer)

Salicylmethylecgonine (2'-Hydroxycocaine)
(Its potency in vitro is around 10x that of cocaine,[2] although it is only around three times more potent than cocaine when administered to mice.)

Difluoropine
(S)-(+)-2β-Carbomethoxy-3α-(bis(4-fluorophenyl)methoxy)tropane (Difluoropine, O-620) is a stimulant drug synthesised from tropinone, which acts as a potent and selective dopamine reuptake inhibitor.)

Cocaethylene
Cocaethylene appears to, in most users, produce more euphoria and possess a longer duration of action than cocaine. Some studies suggest that it may have a higher cardiovascular toxicity than cocaine. Cocaethylene is more potent than cocaine at binding to the dopamine transporter, however it is less potent at binding to the serotonin transporter and norepinephrine transporter

The one I'm hoping for the most is Troparil, and I would like to know if anyone has tried it and can compare it to cocaine for me.
 
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The branch missing that removes the voltage gated sodium channel action potential from cocaine to make troparil makes it no different really than methylphenidate (Ritalin, Concerta). An overlay of dextro-methylphenidate and Troparil molecules in 3D look nearly identical. So removing that branch also changes something to do, either via the action potential which causes sodium channel blocking, or just the conformation of the binding to the dopamine receptors, it enough to make Troparil, though better at binding to monoamines, less euphoric in the same way that Ritalin is.

I looked into the phenyltropanes, and they don't seem promising in terms of ever being more euphoric or having more of a rush than cocaine itself. Their longer duration of action itself, attests to that. Cocaine's particular euphoric type compared to other stimulants is in its extreme hygroscopic nature and fast onset and short duration of action.
 
The guy who came on here and told us about using troparil and giving it to friends made it clear that it is abusable, long-lasting, and addictive as feck; whether or not that poster is to be believed or not is up to you.

MDMA, MDA, MDE, AMP, METH, ETH, and MESCALINE also have no Ph-(C=O)-O-R linkage, and they are also as euphoric as fock.

The ester linkages of coca, especially that heavier phenyl ester linkage of coca, is why it's such an easy target for quick metabolic catalysis in vivo or with an acid or base in a beaker, for that matter.
 
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The guy who came on here and told us about using troparil and giving it to friends made it clear that it is abusable, long-lasting, and addictive as feck; whether or not that poster is to be believed or not is up to you.

MDMA, MDA, MDE, AMP, METH, ETH, and MESCALINE also have no Ph-(C=O)-O-R linkage, and they are also as euphoric as fock.

The ester linkages of coca, especially that heavier phenyl ester linkage of coca, is why it's such an easy target for quick metabolic catalysis in vivo or with an acid or base in a beaker, for that matter.

Troparil certainly would be extremely addictive and reinforcing just looking at it with a knowledge of stiimulants of that class (related to piperidines), though it, "potency" higher or not, hits only like a pure methylphenidate sans pill binding process common to prescribed, supposedly, and not as good as pharmaceutical grade or pure extracted cocaine (made hydrochloride) from coca.
 
Well the first is more potent at reuptaking dopamine but is weaker at reuptaking serotonin making it not a very good candidate (would probably be a bit more 'fun' than bupropion according to the article).

The other seems to be undoubtably the winner as it is 5 times more potent at reuptaking all three monoamine transporters (with some selectivity for dopamine..essential to stimmulants) than cocaine.
EXP-561 is also a curious one.
Have a look at this page also: http://en.wikipedia.org/wiki/Triple_reuptake_inhibitor
 
Well the first is more potent at reuptaking dopamine but is weaker at reuptaking serotonin making it not a very good candidate (would probably be a bit more 'fun' than bupropion according to the article).

The other seems to be undoubtably the winner as it is 5 times more potent at reuptaking all three monoamine transporters (with some selectivity for dopamine..essential to stimmulants) than cocaine.
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Sure, a winner like naphyrone, another TRI. Everyone's favourite 8) .
 
yeah, the TRI's haven't exactly been well received as recreational drugs. that's kind of the point, though.

cocaines effect at SERT is fairly weak, weak enough that I'd hardly consider it a prerequisite for a good cocaine like stimulant.
 
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