Opioids Cimetidine vs grapefruit, timeline

[RedRum OG]

For opioids, does anyone have personal experience or online evidence/proof of cimetidine or grapefruit being better for potentiation? Are they basically the same? (Obviously grapefruit juices have widely varying levels of everything, this isn't the point) Do cimetidine and grapefruit inhibit the exact same enzymes? Is there any added benefit in using both?

2nd question is: when is it best to take? I usually do an hour before orally dosing. Is this too soon or too late or just right? Any re-dosing advice/info?

Tl;dr- what's the difference between cimetidine and grapefruit as far as opioid potentiation, when is it most efficient to take in relation to opiate dose?

(Oxycodone specifically, but Suboxone too)

 

[brutus]

I would lean toward using GFJ ever since a close friend of mine developed gynecomastia from using cimetidine to potentate opiates.

 

[tricomb]

T-1h : Drink a tall glass of GFJ (I drink close to 500mL)
T-30mins: hydroxyzine/diphenhydramine
T-15mins: cannabinoids
T-0: Dose the opioids.

 

[fairnymph]

I've used both for heroin & hydromorphone, and I get more effect from 2 x 400mg cimetidine tablets, which I usually take 15 minutes before my opiate & every 8 hours thereafter, than I've ever gotten from grapefruit. Unfortunately, I seem to develop a tolerance to cimetidine such that after 3 days of continual use it barely works, so I recommend using it every other day if you're a daily opiate user.

The effects from grapefruit are so subtle I don't usually bother unless I have it on hand. That said, peeling a white (not pink!) grapefruit & eating the slices the way one would with a peeled orange seems to be stronger than just drinking the juice.

 

[Choosing_Positive]

T-1h : Drink a tall glass of GFJ (I drink close to 500mL)
T-30mins: hydroxyzine/diphenhydramine
T-15mins: cannabinoids
T-0: Dose the opioids.

LOL, I like it. A recipe to get lit!! T+1hr: Lit as fuck, do no drive or operate heavy remote controls, watch out for cigarette nods and rambling, incoherent conversations... hahaha

 

[Snake_Eyes]

I would lean toward using GFJ ever since a close friend of mine developed gynecomastia from using cimetidine to potentate opiates.

Tits from tagamet? WTF? How long and what amount was he taking?

 

[bingey]

500 ml glasses! You live in the states tricomb?

Anyway I find that the the effects of white grapefruit juice are pretty steady but do fade away with repeated use. Ps fairnymph the reason why fresh peeled grapefruits work so well is that the coumarins are most most concentrated in the skin/rind of the grapefruit , in juice these elements get exposed and destroyed. If you can stomach it try eating a little skin (burns though)

 

[fairnymph]

^ I suspected that was why, and if I could find organic grapefruits in Germany I'd totally try eating the peel. I've been able to find every other type of organic citrus, but not grapefruit. And as pesticides are concentrated in the peel, I'm not keen on eating peel from conventional citrus.

 

[tricomb]

I know right, big glass for a big boy, haha.

I prefer to use freshly squeezed (organic duh) grapefruits as my source of GFJ, but the avg GF only yields maybe a couple hundred mL.