Harm Reduction Careless mixing of drugs not to mix; tapentadol, DXM, duloxetine, edible cannabis - serotonin syndrome or bad trip?

[LucidSDreamr]

I’m a person that can recite the pharmacological profile of any recreational drug by heart and also thus can easily guess know which to not mix based on similarities or contradictions in their overlap.

I’m also a drug addict that swallows pills like pac man and is too stoned to even stop and think about what I’m taking sometimes. I made a mistake and mixed some drugs and has a bad experience. Wondering if it was serotonin syndrome.

I am tapering off of duloxetine and been taking 20 mg about 2X a week to ward off withdrawal. The night of the incidence I took the drugs as listed below in time and after the tapentadol and weed really kicked in I had some symptoms of serotonin syndrome perhaps? Or what was it? I had extreme really good euphoria rushes somewhat like an opioid but better, almost like mdma, at first with some light psychedelic visuals. Then my heart began racing, I began shaking, pupils were dilated, and the cure was a 30 mg dose of diazepam which stopped it all and brought be back to safety. You think it was light serotonin syndrome,

0:00. 20 mg dukoxetine and 30 mg DXM

2:00 edible cannabis ~50 mg THC

3:00 tapentadol 75 mg

5:00 the bad part happened

 

[negrogesic]

The diagnostic criteria is straightforward, and simultaneously not that straightforward due to some degree of subjectivity in assessing these symptoms (especially self-assessment):



Personally, I think alot of self-reported cases of serotonin syndrome would be dismissed if said person was evaluated in the ER.

A 50mg THC edible would have me thinking all kinds of things (paranoia is strong at that dose).

 

[LucidSDreamr]

The diagnostic criteria is straightforward, and simultaneously not that straightforward due to some degree of subjectivity in assessing these symptoms (especially self-assessment):



Personally, I think alot of self-reported cases of serotonin syndrome would be dismissed if said person was evaluated in the ER.

A 50mg THC edible would have me thinking all kinds of things (paranoia is strong at that dose).

I’m a little confused following this flowchart assesses what happened to me. Re clonus and hyperrreflexia; I was shaking that’s all I can say. Don’t know if that would qualify as clonus or hyoerrflexia.

50 mg THC is a guess but also isn’t particularly high for me because I have a super high tolerance to edibles and even 100mg is a dose I will commonly do without ever having a negative reaction. However that was a home made edible so the dosage wasn’t exact but estimate, based on prior dosing of that batch of edibles and the strength of the THC high. I estimate That it was about 50 mg.

I haven’t used serotonergic recreational drugs in about a decade but I remember some very similar and bad experiences mixing weed with things like dxm, or mxe.

Mixing only weed and tapentadol I’ve done and it’s not a friendly combo, I trip pretty hard on tapentadol by itself and adding weed just ramps up a panicky feeling that feels like I’m on the verge of a panic attack/ bad trip. However this was such a low tap does at 75 mg. A true psychedelic dose of tap for me is 250 to 300.

Probably to many variables and other drugs here to make sense of it.

The fact that diazepam just completely ended it makes me think it wasn’t serotonin syndrome. Does that sound correct?

The euphoria before it got bad was something else though. I hadn’t felt euphoria specifically like that since doing empathogenic drugs, has much more of a rushy feeling to it than standard opioid euphoria. It was really good and makes me want to chase it again but yea not worth the scare I went through and I put my partner through.