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Cannibis combo experiment with Theophylline(xanthine group)

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gruff

Greenlighter
Joined
Nov 18, 2008
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15
Location
South Africa
Here's a combo for regular smokers to try out with their weed.
Theophylline is a xanthine as is caffine, and is present in Yerba Mate.
Take 150mg Theophylline with your regular amount of cannabis.
Theophylline is a stimulant so watch your dose. Best to follow indications.

I obtained 300mg Theophylline tabs from my neighborhood pharmacy. They are white and bevel shaped with a score line. It's used for asthma, COPD etc.
It was an interesting enough experience to repeat.

I've had 2 experiences so far and am interested to know what others have to say about theirs.


I'll refrain from listing my subjective experiences just yet. I don't want to influence your experience before you try it yourself.


Now drop by you local drug-store pick up some theo, roll up a joint and give it a go.:D
 
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i would recommend and hope that people would at least do base research on drugs before going out and mixing them with cannabis, instead of just taking someones ^ word for it.

not saying anything against gruffs info but please research drugs if you're going to use them for the first time people.


that is all.
 
I couldn't agree more Sega420. I guess could have put a friendly reminder to those peeps out there but I figured them as responsible trippers. That said, Theophylline is asthma meds so I figure that some regular smokers may at least have had it in their system while toking away. In fact, marijuana interacts directly with Theophylline by increasing clearance by about 50%.
A good experiment for regular responsible trippers tho and those interested in combos. Or you could hold on to your moral beliefs and remain faithful to one woman-Mary Jane.:)
 
unfortunately we cannot rely on others to be responsible with data we provide.

you'd be surprised how many people would do it if i posted a thread saying "hey mix anthrax with ur weed it gets you higher". really.
there was a thread on smoking a corpse of a cannabis smoker's lung to get thc. :/


heophylline, also known as dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as COPD or asthma under a variety of brand names. Due to its numerous side-effects, these drugs are now rarely administered for clinical use. As a member of the xanthine family, it bears structural and pharmacological similarity to caffeine. It is naturally found in tea, although in trace amounts (~1 mg/L),[1] significantly less than therapeutic doses.[2] It is found also in cocoa beans. Amounts as high as 3.7 mg/g have been reported in Criollo cocoa beans.[3]
The main actions of theophylline involve:
relaxing bronchial smooth muscle
increasing heart muscle contractility and efficiency: positive inotropic
increasing heart rate: positive chronotropic
increasing blood pressure
increasing renal blood flow
some anti-inflammatory effects
central nervous system stimulatory effect mainly on the medullary respiratory centre.

Bioavailability is 100%. However, taking the drug late in the evening may slow the absorption process, without affecting the bioavailability. Taking the drug after a meal high in fat content will also slow down the absorption process, without affecting the bioavailability.






sounds pretty good man.
so it enables more thc to get into the system?

im a little confused.

i understand xanthines are a base in many human fluids and tissues?
 
Interesting question Sega. I've too been wondering if affects the amount of THC absorbed/processed in your system. I hesistate to make such claims but someone may very well say so even if untrue. So far I don't know. No research to back this up. Or perhaps I am missing elemenary knowledge that would answer this question. Hopefully someone with some biochem understanding of these drugs could answer the question.

If you decide to give it a try sega420, which I hope you do then let me know what you experience.
 
well i stay in the UK, so im not aware of the availability of this drug OTC.
what is the combination like in regards to how it changes the high (if it does)?

ie what benefits does it give over each substances separate use?

have you experimented on the processing times ie how well/different the effects are at different varying times of ingestion for each substance?




ive tried caffeine and cannabis before, was a small dose (cant remember exact number) and gave the high a sort of "sharp" edge to it.


i know you said you'd hold back your experience so as to not sway other peoples, however i need info before i conduct experiments on myself.
(not sarcasm, im into psychonautics and med science/chemistry)
 
Can you describe what the high is like? The drug is in the same family as caffeine so why not just take that? What makes Theophylline special?
 
yeah as sega has been saying, it would be nice to have a little more info before i go experiment with drugs i''ve never heard of/used before
 
Good info Sega420.
I'm still trying to make sense of all the info out there. Still have lots to learn on subject of pharmacokinetics. My understanding of Theophylline is still v. limited and research on its interaction with other drugs appears fragmented.

Smoking increases metabolism of Theophylline, a CNS stimulant. So I imagine smoking a cigarette or joint should be accompanied by a noticeable buzz akin to caffeine.
Also there is a complex interaction with the cytochrome P450- the family of enzymes responsible for most of our drug metabolism. If Enzymes CYP1A2 and CYP3A4 are common to THC, CBD and Theophylline metabolism then we might be onto something. From what I’ve been able to glean from the net Theo has been proven as a substrate of both and also a weak inhibitor of CYP1A2. CBD also inhibits CYP3A4.

But what does this mean for those who combine Theophylline with Cannabis? Does it synergize well? Is it comparable to a caffeine combo? Is it safer than using ephedrine?

Well I've tried it a few times now and it seems to be quite positive in its effects upon cannabis. It is a metabolite of caffeine so taking even small amounts may do the job for you. Synergy appears clean, minimizing body and mental fatigue so you could probably smoke more and get higher (& maybe even reach the rank of 'Cool' lol) Smell and touch appears enhanced. Depersonalisation or DXM-like effects seem apparent although not as strong. Auditory perception seems improved with possible hallucinations echo etc. I've had no negative effects yet at low doses I've been taking. (Usually 1/4 to 1/2 tab of 300mg)
The therapeutic margin is narrow however, which explains its fall out of popularity. But this shouldn’t be a major concern if you're being a responsible drug person. There’s more but I'm not sure all are valid. Might just be my imagination. Theophylline seems to enhance the positive effects of cannabis perhaps even potentiate. That’s just how it feels, not sure if it does pharmacologically. Well that's a brief description of my combo experience.

Maybe those with a bit of understanding on pharmacokinetics or how drugs are metabolised could help us understand the interaction. And those adventurous enough who try it could help recognise its effects, efficacy and tolerance etc. But I think were onto something here and it deserves some investigation.

As The Dude would say, "This is a very complicated case... A lot of Ins, a lot of Outs." %)
 
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