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can the effects of ghb be countered?

A

**AJ**

Bluelighter
Joined
Sep 10, 2000
Messages
141
Location
Sydney, Australia
Hi everyone,
I know there's a couple G threads going around atm, but I've searched and can't find what I'm looking for...
So, if someone's taken more g than they should (ie feeling like they might soon pass out) is there anything you can do to stop this? I understand G works by increasing dopamine production and simultaneously supressing it's release in the synapses. So would amphetamines (most likely speed) cause the build-up of dopamine to be released and stop someone passing out? Any info or experiences with combining g and speed would also be good.
AJ =)
 
I don't know about from a medical viewpoint, or even from a view of stoping someone from "G'ing out"...
But I do know that G and amphetamines (commonly known as the "G-Wizz Combo"), is a really awesome feeling! :D
Now that that's been said, it'd be interesting to see exactly how safe/bad this combo is from someone that knows... :)
 
Taking amphetamines prior to g does increase tolerance for g, see erowid.
Perhaps the dopamine effects aren't responsible for g's hypnotic effects - it may be due to some of the other effects such as
binds to GABA-B receptors in the brain, inhibits noradrenaline release in the hypothalamus, and mediates the release of an opiatelike substance in the striatum. It produces a biphasic dopamine response, increasing release at high doses and inhibiting release at lower doses. (from Toxicity, Gamma-Hydoxybutyrate
The only suggested treatment to reverse G poisoning (from the same article):
Although physostigmine has been shown to reverse sedation in clinical trials, presently, some experts believe that the risks of physostigmine use (eg, bradycardia, asystole, seizures) outweigh the benefits in most GHB ingestions and that it should be reserved for selected cases, if used at all.
I also checked Poisindex - it states there is no specific antidote for G, other than phyostigmine. I'm thinking that if amphetamines worked, it would be documented, but ...maybe not. I wonder about dopamine agonist drugs like bromocriptine, but again, perhaps the dopamine effects aren't the cause of g sedation.
AFAIk there is no specific treatment you could use at home, or for use in the hospital, to reverse g sedation (except phyostigmine). Therefore the best thing to do would be to get the person comfortable on the floor, so you can get them into the coma position if necessary, then observe them closely. If they start having seizures, vomitting and choking or breathing in vomit, or their breathing is impaired, you need to think seriously about calling an ambulance.
Click to expand...
Click to expand...
 
I cannot say exactly what you can take to stop soemone from going too far if they've had too much, But from past experiences I've found making someone throw up seems to help.
Now this is only from MY point of veiw. Also anyone who I have had chuck in front of me I have chucked in the shower and stayed with them. Not because I was too worried, I just wanted to make sure they were OK and snapped out of it....
 
From experience Id have to say amphetamines are the only thing that has upped my tolerance to GHB (or 14B).. I would say some meth or alike would possible stop someone "g-ing out" , but obviously depends on how overboard they have gone.
Throwing up is alos a good option, but this has to occur quickly if it is to work, such as in the case of known accidental overdosing.. (ie someone has a swig and then goes "hey that didn't tatse like water"...)
 
i've found getting up and moving around helps to decrease the effects of GHB. you might look really, really unco-ordinated, but at least you wont pass out.
M
 
if you drink orange juice with G it raises your tolerance significantly. i've found if i dose with a glass of OJ (works well at blocking out that crap taste) i hardly feel the effects an di have to nearly triple my dose to feel anything.
i guess if someone acidentally od'd, if you quickly gave them 3 glasses of OJ or something, it would probably dilute it before your stomach had a chance to absorb it..
 
Can that be anything else but placebo effect or set and setting? I've been trying to find any chemical references for reasons that GHB might take longer to work when mixed with orange juice, but so far I've come up blank. Maybe I'm looking in the wrong places.
Or did you mean mixing 1,4-butanediol with orange juice?
BigTrancer :)
 
The biggest thing that effects the streghth of a dose, is whether you have eaten recently or not. It is stronger on an empty stomach.
M
 
Nah Sifu, my point is - I searched everywhere for information on why GHB might change potency when taken with OJ but I found nothing. I wasn't about to repeat all the searches using 1,4B as the topic until I figured out more details.
The only possible mechanism I could figure would be taking some food that competed for metabolism with the same enzymes in the liver that convert 1,4B into GHB... and I'm not even sure that OJ would contain anything that would accomplish this (a la taking grapefruit juice with MDMA to compete for cytochrome P450). That indeed may be a gross over-simplification of the process, however, and if something was competing for metabolism I think it would *potentiate* the effects of the drug, not diminish them.
I think it might be mostly set/setting/placebo though, or variations in concentration - perhaps the bottle had sat for awhile and wasn't thoroughly mixed.
BigTrancer :)
 
hahaha, fuck me, 1,4b and oj... fine example of why i hardly ever check out these boards
 
unless Luko can back that up with some scientific evidence, I would like to suggest that it is total BS- as is almost every other myth about OJ being a potentiator; alternatively as a way to stop people tripping, or reduce the effects of drugs.
I have always had my GHB (or 2,3 furanone di-hydro, or GBL, or 1,4 butanediol, or glycol-b or whatever GHB analogue) with juice, and indeed I have had it with many other mixers (lemonade, coca-cola, Fanta) and I have never noticed any difference whatsoever in dose tolerance and strength, onset, or duration. If anything, the caffiene in some soft drinks can slightly delay the onset.
As GHB enacts mostly on the dopamine release mechanism, I can think of no way that Orange Juice or associated enzymes would have any effect on this pathway, nor can I find any evidence thereof on the net.
Simple conjecture, side order of urban myth and a healthy dose of placebo.
 
speed the best explanation i can come up with for not endng up in casualty after drinking on ghb.
trust me, this was like 4 years ago when no one was saying not to drink on it.
but i dont recommend it. U might not be so lucky.
 
Pinger, vitamin C does bring down trips for me, but that's cos I'd heard about it and tried it once before the myth was debunked completely for me. Now it works almost every time. I know it's all completely psychosomatic, but really, who cares, for me it works :)
Back to G, it does take a fair amount of G to be dangerous on its own. So if someone does G out, often it would just be best to let them sleep and keep an eye on them. If they are sound asleep, and breathing deeply, then there shouldn't be a problem. I had my gf passing out on me a lot before I realised I shouldn't be giving her the same dose as me (duh), and although she was completely uncontactable to the outside world, I have never felt that she has been in any danger.
I also believe things like making someone vomit and cold showers may help also. I think Ging out should be treated similarly to passing out on alcohol. Just keep em warm, make sure their breathing is ok and that they dont choke on their own vomit.
 
After scanning a book about GHB by Dr. Steven Fowkes, the reason for taking GHB (and I assume 1,4B) with orange juice is because of pH.
One is a base, one is an acid. Combine and you get a pH that is a lot friendlier to your stomach (I guess adding very basic substances to your acidic stomach can cause some discomfort...)
 
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