Stimulants Can an amphetamine comedown potentiate an opioid?

[Ksa]

I laughed in my sleep all night last day and felt super good, first time it happends. If you get over excited with an upper, can the body balance downwards, resulting in a downer effect during comedown?

Thanks,

 

[Psychedelic Jay]

Yes.

There is a down period afterwards. That is why you are so tired after heavy usage.

It is the rebound effect of overloading neurotransmitter sites.

 

[Ksa]

Yes.

There is a down period afterwards. That is why you are so tired after heavy usage.

It is the rebound effect of overloading neurotransmitter sites.

thanks