So they are studing this combination as anti-depressant, bupropion will increase the plasma level and slows the metabolism of DM.
en.wikipedia.org
www.ncbi.nlm.nih.gov
The observed DM antidepressant effect with onset over 3–48 hours and lasting 7 days after a single administration and 20 days with daily administration is strikingly consistent with the rapid—acting antidepressant effects seen with ketamine, which has provided a sustained antidepressant response for less than one week after a single dose and about 18 days with 6 consecutive ketamine infusions.7 DM also evidenced a treatment—resistant antidepressant response (this patient failed adequate trials of citalopram and vortioxetine). Ketamine response has been predicted by a family history of alcohol dependence;8 the patient’s family history was mildly positive for alcohol use disorders. The duration of DM response was not consistent with a conventional antidepressant response although this might be obtainable in a different dose range.
Upon full relapse in DSM-5 MDD while taking 600 mg/day of the strong CYP2D6 inhibitor bupropion XL, a 300 mg oral loading dose of DM was given, followed by 60 mg po bid after an additional dose—finding period, without side effects.
The dose of Bupropion seems pretty high, the max. dose is 450mg as after that the seizure risk will rise, so I think it's unsafe to test this at home. But it seems they administer it only once, so maybe if taken with some benzos to prevent possible seizures it's safe to try at home.
But for me bupropion by itself is only working anti-depressant that is daily used, of course ketamine and psychedelics are the best ones, but they are hard to get sometimes.
Dextromethorphan/bupropion - Wikipedia
Treatment Resistant Depression with Loss of Antidepressant Response: Rapid—Acting Antidepressant Action of Dextromethorphan, A Possible Treatment Bridging Molecule - PMC
Dextromethorphan (DM) may have ketamine—like rapid—acting, treatment—resistant, and conventional antidepressant effects.1,2 This reports our initial experience with DM in unipolar Major Depressive Disorder (MDD). A patient with treatment—resistant ...
www.ncbi.nlm.nih.gov
The observed DM antidepressant effect with onset over 3–48 hours and lasting 7 days after a single administration and 20 days with daily administration is strikingly consistent with the rapid—acting antidepressant effects seen with ketamine, which has provided a sustained antidepressant response for less than one week after a single dose and about 18 days with 6 consecutive ketamine infusions.7 DM also evidenced a treatment—resistant antidepressant response (this patient failed adequate trials of citalopram and vortioxetine). Ketamine response has been predicted by a family history of alcohol dependence;8 the patient’s family history was mildly positive for alcohol use disorders. The duration of DM response was not consistent with a conventional antidepressant response although this might be obtainable in a different dose range.
Upon full relapse in DSM-5 MDD while taking 600 mg/day of the strong CYP2D6 inhibitor bupropion XL, a 300 mg oral loading dose of DM was given, followed by 60 mg po bid after an additional dose—finding period, without side effects.
The dose of Bupropion seems pretty high, the max. dose is 450mg as after that the seizure risk will rise, so I think it's unsafe to test this at home. But it seems they administer it only once, so maybe if taken with some benzos to prevent possible seizures it's safe to try at home.
But for me bupropion by itself is only working anti-depressant that is daily used, of course ketamine and psychedelics are the best ones, but they are hard to get sometimes.
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