rules
Bluelighter
Hypothetically, how much Buprenorphine would one have to snort to get the maximum amount of bupe metabolized into norbuprenorphine?
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OD Moderators: Keif’ Richards | negrogesic
Bupe Buprenorphine and norbuprenorphine
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IF you want maximum amount of norbuprenorphine u want to take maximum amount of bupe? The trick is at what dose the metabolized norbuprenoprhine would still find enough places to stick on to without bupe blocking it. Meaning that you would want to maximize norbuprenorphine concentration in your receptors (maybe this is what you actually ment). I believe that is a question for which only qualified scientist could give some answers.
Ashley
Bluelight Crew
I thought more norburprenorphine was around at lower doses of buprenorphine (2mg and less)?
rules
Bluelighter
so did i...
No, buprenorphine is metabolized to norbuprenorphine which is a full agonist. However at higher doses the buprenorphine not yet metabolized blocks the effect of already metabolized nobuprenorphine. At lower doses the receptors arent saturated with bupe, so one can feel the norbuprenorphine full agonist effects also. At least this is what I have understood.
Znegative
Bluelight Crew
That's the theory. The problem is that I keep reading different findings on the potency of norbuprenorphine. Some seem to claime it's a potent agonist where others say its weak.
Another reason that buprenorphine could have more 'pure' agonist effects, is that at lower dosages (<2mg), there is a steeper drop and a larger spike in buprenorphine blood levels between dosages, just like how you feel heroin the strongest in the morning (because you've probably gone the longest period of time without it during a 24 hour period, allowing more of the heroin to disassociate from the opiate receptors)
Another reason that buprenorphine could have more 'pure' agonist effects, is that at lower dosages (<2mg), there is a steeper drop and a larger spike in buprenorphine blood levels between dosages, just like how you feel heroin the strongest in the morning (because you've probably gone the longest period of time without it during a 24 hour period, allowing more of the heroin to disassociate from the opiate receptors)
amanitadine
Bluelighter
^^^ this. The whole bupe/nor-dupe thing doesn't have any basis in reality, it's all about the plasma levels. If nor bupe was the tits, then taking it orally would rock you. Why? First pass metabolism is straight to nor-bupe. . . .
Znegative
Bluelight Crew
Thanks you. I've researched this topic to the best of my ability in the hope that the whole norbuprenorphine thing could be proven true, but everything I've found has been inconclusive, or contradictory. I've even heard sme sources say that norbuprenorphine would most likely be dysphoric, though I forget the exact reason why, I'll have to look it up later.
In the end it doesn't matter whether it's norbupe or bupe that's getting you 'buzzed'. As long as you stay on a low dosage, you'll feel the drug way more.
In the end it doesn't matter whether it's norbupe or bupe that's getting you 'buzzed'. As long as you stay on a low dosage, you'll feel the drug way more.
In theory the dysphoria would be caused by the kappa-receptor agonism, in which the norbuprenorphine has more activity by some sources. I guess we would have to wait until some comes up with pure norbuprenorphine as design drug or something to really find out what are the properties of metabolites. But even then things wouldnt be that simple, because there might be some kind of dynamics between buprenoprhine and its metabolites.