how much bup are you taking? how long after doing pods did you take your sub? have you been taking the same dose every day, or taking random doses? what ROA are you utilizing to take your suboxone?
bup should definitely "work," there is no way it wouldnt, that wouldnt be logical. maybe you are takin to much sub, which i think is probably why you feel that way. try to stay between 1-2mgs a day, this dose will give you the best effect definitely. by taking a low dose,, there wont be enough bup to occupy all your receptors leaving some unoccupied, bup will metabolize through 3A4 which is part of the cytochrome 450 family, enzymes apart of this class consist of 75% of all the enzymes in the liver. out of 75%, 3A4 is more abundant making up around 40% of the 450 family.
oh yah, i forgot to say, norbup is a full agonist at mu receptors, and has some affinity for other opiate receptors. bup is metabolized to norbup through 3A4, and since this enzyme is so prominent, a decent amount of bup will be metabolized to norbuprenorphine. in concluson, if you took a low dose leeaving unagonized receptors, norbup will have a good chance at binding with those receptor sights resulting n a feeling that is more "Agonistic," cleaner, feels better ( a little more euphoric). so the best effects come from taking 1-2mgs, some people say 2mg is the limit, some say 1, some say 4. so just stay between .5-3mgs.
if you took a high dose though, you will get a more antagonistic effect from mainly bup occupying most if not all receptors. bup beats norbup at binding affinity (Strength) . bup will inihibit norbup to bind because of the extremely powerful binding affinity bup has at mu\
i found some days i get extremely nauseous and feel like shit. most of the time this happens when i take a day or two off from bup. usually im pretty tolerant, but the naloxone and the bup definitely cause nausea. and high doses most likely cause anxiety
