Opioids Bupe after methadone with no dependence

[LucidSDreamr]

I have no dependence on opioids. If I took 5 to 10 mg of methadone then take 2 mg of bupe like 9 hours later, a precipitated withdrawl shouldn’t happen right? Because I have no withdrawl to speak of anyways.

Also 2mg of bupe is way stronger than 5 to 10 mg methadone.

 

[DLTL25]

I have no dependence on opioids. If I took 5 to 10 mg of methadone then take 2 mg of bupe like 9 hours later, a precipitated withdrawl shouldn’t happen right? Because I have no withdrawl to speak of anyways.

Also 2mg of bupe is way stronger than 5 to 10 mg methadone.

Huh, I have no idea. I don't think you would go into WD if you have no dependency on opiates but why would you want to do this in the first place?

 

[NawdybyNature]

Are you trying to catch a buzz, or what is the reason for you trying this? Just curious. I believe Buprenorphine has a higher affinity (lower Ki value) than methadone does, plus methadone is a full agonist. Taking bupe too early after taking methadone might throw you into PWD. Maybe not at the low doses you are talking about, but you generally don't want to be taking bupe directly after any other full agonist opioid because it is going to rip said opioid (methadone in this case) off your mu opioid receptors so that the bupe can slide in. It's this "replacement" that causes the extreme discomfort known as PWD. This is part of the reason (plus methadone's long half life) that patients switching from methadone to suboxone/subutex have to wait such a long time before taking their first bupe dose.

 

[LucidSDreamr]

Are you trying to catch a buzz, or what is the reason for you trying this? Just curious. I believe Buprenorphine has a higher affinity (lower Ki value) than methadone does, plus methadone is a full agonist. Taking bupe too early after taking methadone might throw you into PWD. Maybe not at the low doses you are talking about, but you generally don't want to be taking bupe directly after any other full agonist opioid because it is going to rip said opioid (methadone in this case) off your mu opioid receptors so that the bupe can slide in. It's this "replacement" that causes the extreme discomfort known as PWD. This is part of the reason (plus methadone's long half life) that patients switching from methadone to suboxone/subutex have to wait such a long time before taking their first bupe dose.

Yea but I’m not dependent so there is no withdrawal state to precipitate into.

I’m pretty sure that if you give naloxone to an opioid OD patient with no dependency they do not have a withdrawl and simply wake up. This is how veterinary anesthesia is done on large zoo animals (using etorphine then naloxone)

 

[LucidSDreamr]

Huh, I have no idea. I don't think you would go into WD if you have no dependency on opiates but why would you want to do this in the first place?

I wanted to get high later and if you’re non dependent or have a very low tolerance I find bupe to be far more recreational than methadone.

2 mg of bupe with no tolerance is almost as good as any of the best opioids imo. 20 to 30 mg of methadone with no tolerance is alright but it’s just not warm in the way the thebaine/morohine family of opioids are and bupe is included.

The methadone is stoning and almost more stimulating and I can feel the NMDA antagonism when my tolerance to it is low and I take a higher dose….indont like those effects that much.

I know once you have a tolerance bupe is shit and methadone is better; but I’m one of the few that likes bupe with no tolerance.

 

[NawdybyNature]

Gotcha, ya bupe definitely has some recreational value if you don't have a tolerance to opioids. I don't have much experience with methadone, but you're right, it feels very stoning and is probably just going to put you to sleep.


If you are going to use them to get high, I'd use them separately. Or if you are going to combine them, I would use the bupe first and the methadone second to avoid any chance of PWD. Such a small dose of bupe should allow for the methadone to occupy some of the receptors it doesn't fill. You will undoubtedly be wasting some of the methadone if you combine them because of how effective bupe is, but maybe you can find a nice low-dose combo. Good luck!

 

[LSDiesel]

Did it work? Were you able to get high? I myself am on methadone maintenance so I can’t try this now, but I swear I had a few successful bupe highs by two methods

Method one: vaping subs strips in a pizo meth pipe

Method two: toasting subs in a microwave basically to the point of golden brown like watching it like a hawk and at the point where it starts cooking and you see it start to burn even a little turn off the microwave or heat.

I believe this is breaking down the buperenorphine into norbuperenorphine and the effects are nearly indistinguishable from a good oxy rush, noddy yet stimulating sometimes even like a dilly rush but I couldn’t repeat it I only got it right like maybe one out of ten times I tried and I tried probably about 30 to 50 times so like maybe 4 times I got that good bupe high

 

[LucidSDreamr]

Did it work? Were you able to get high? I myself am on methadone maintenance so I can’t try this now, but I swear I had a few successful bupe highs by two methods

Method one: vaping subs strips in a pizo meth pipe

Method two: toasting subs in a microwave basically to the point of golden brown like watching it like a hawk and at the point where it starts cooking and you see it start to burn even a little turn off the microwave or heat.

I believe this is breaking down the buperenorphine into norbuperenorphine and the effects are nearly indistinguishable from a good oxy rush, noddy yet stimulating sometimes even like a dilly rush but I couldn’t repeat it I only got it right like maybe one out of ten times I tried and I tried probably about 30 to 50 times so like maybe 4 times I got that good bupe high

You should search Google scholar to see what the heat decomposition products of bupe are. See if norbupe is significant or any other full agonist.

I would not put it past using sophisticated chemistry to also react bupe into a full agonist using one or two reactions….its so similar to many full agonists. Would be beautiful if someone perfected a way to do this. We would be able to transform widely available bupe into something as good as oxy/heroin.

Did it work? I have no dependence. I obliterated on 2 mg of bupe (nodding two days straight) 3 days after 10 mg of methadone.

Repeated this twice.

So that’s what I’ve tried.

Also makes me wonder about the equivalency of bupe to methadone. To me I would say for the non tolerant; 2mg of bupe is an equal high to about 30 to 40 mg of methadone. Like I hadn’t had too many trials with bupe being totally clean but oh my god was I fucked off 2 mg.

 

[DUMB ASS]

I have no dependence on opioids. If I took 5 to 10 mg of methadone then take 2 mg of bupe like 9 hours later, a precipitated withdrawl shouldn’t happen right? Because I have no withdrawl to speak of anyways.

Also 2mg of bupe is way stronger than 5 to 10 mg methadone.

WTF IS WRONG WITH YOU MAN???
IF YOU HAVE NO PHYSICAL DEPENDENCE, WHY WOULD YOU WANT ONE??? BECAUSE IF YOU KEEP DABBLING, THATS EXACTLY WHAT I 110% GUARANTEE IS GOING TO HAPPEN...LOOK,,,I KNOW HOW GREAT THE FEEL AS MUCH AS THE NEXT GUY, BUT TAKE OTHER MORE EXPERIENCED USERS WORDS TO HEART AND STOP PLAYING WITH POISENOUS SNAKES OR YOU WILL WISH YOU DID...SAID WITH ALL DUE RESPECT AND CARE.....STOP IT MAN,,,SMOKE SOME WEED OR SOMETHING...BE COOL LITTLE BROTHER AND LISTEN TO ME...I TOO WAS TO GOOD TO EVER DEVELOP A HABIT OR MUCH LESS PHYSICAL ADDICTION, BUT HERE I AM AS A 40 YEAR USER DONE WITH AS MUCH CAUTION AND CARE AS POSSIBLE....STOP FUCKING AROUND,,,,LIFE HAS MUCH BETTER THINGS TO DABBLE IN!!!!!STOP

I have no dependence on opioids. If I took 5 to 10 mg of methadone then take 2 mg of bupe like 9 hours later, a precipitated withdrawl shouldn’t happen right? Because I have no withdrawl to speak of anyways.

Also 2mg of bupe is way stronger than 5 to 10 mg methadone.

 

[LucidSDreamr]

WTF IS WRONG WITH YOU MAN???
IF YOU HAVE NO PHYSICAL DEPENDENCE, WHY WOULD YOU WANT ONE???

From your post I can see that you’re not even aware that people take drugs for reasons besides fun. It never even crossed your mind in your life it seems.

I have chronic pain for like 20 years and it’s prescribed to me by a medical doctor annd I’m a doctor. You know, the reason pharmaceutical opioids exist? that’s the reason one might want to take them. Make sense?

If you don’t have chronic pain don’t even bother commenting back because you’ll never understand.

chronic pain patients don’t want recreational junkies that use drugs for fun lecturing them about managing and living with chronic pain.


I don’t smoke weed because it increases pain perception, destroys your lungs and cognitive functions and I have a job where I can’t have my mind altered by a drug that makes you stupid like weed. Thanks for the medical advice though; I’ll run it by my doctor.

 

[LSDiesel]

first of all DUMB ASS, excellent choice of username, you obviously don’t know LucidSDreamer, I don’t really either other than to say the man certainly has plenty of methadone and buprenorphine usage under his belt, years of each, and legally too I might add. I’ve had bupe prescriptions and I am on methadone maintenance for the 3rd time so the supplies were using are at least pharma. Are you really going to be the guy who says we can’t use our legally acquired opiates this way or that way? You have every right to be that guy but hit up an NA meeting man there’s lots of users who are much less educated who need your help and guidance! Street fetty users I’m thinking need that guidance way more than the OP and most who choose to view the thread. Just a suggestion, hope you fix your caps lock key real soon

 

[bingey]

Are you trying to catch a buzz, or what is the reason for you trying this? Just curious. I believe Buprenorphine has a higher affinity (lower Ki value) than methadone does, plus methadone is a full agonist. Taking bupe too early after taking methadone might throw you into PWD. Maybe not at the low doses you are talking about, but you generally don't want to be taking bupe directly after any other full agonist opioid because it is going to rip said opioid (methadone in this case) off your mu opioid receptors so that the bupe can slide in. It's this "replacement" that causes the extreme discomfort known as PWD. This is part of the reason (plus methadone's long half life) that patients switching from methadone to suboxone/subutex have to wait such a long time before taking their first bupe dose.

Pwds are definitately one of the worst experiences of my life along with having my head bashed in on a parking lot.

 

[Keif' Richards]

Yea, I won't use the same technique as our friend @DUMB ASS but yea @LucidSDreamr he is right. I've been reading your posts for a long time now. I really hate to see people who break free who get sucked back in. I know I spend too much time talking about Lord of the Rings and its relation to addiction, but you can all take it or get a new moderator.

When the war of the Grand Alliance defeats Sauron, all they have to do to rid the world of evil forever is to throw the ring into the fire. Thousands died, there was misery, pain, but they won the war that seemed completely unwinnable. It was a miracle. Then Isildur refuses to destroy the ring. He will use its power to make a perfect world he thinks. It's the same thought every man previously had had regarding the ring.

Once you've been a junkie or "Chronically Opioid-Dependent" with cycles of withdrawal interwoven, you're basically fucked man. You will never be able to "enjoy" using Opioids again without extreme peril. You're only going to be able to use for 3 days tops before you are basically right back where you started.

No, Buprenorphine shouldn't cause precipitated withdrawal unless an individual is physically dependent upon Opioids, if this is a one-time thing, this interaction shouldn't be relevant. It will become relevant if you end up doing this for longer than a couple of days though.

 

[LSDiesel]

I too have reached a point of no physical dependence but psychologically it will always hold a special place in my heart, there you have it, I love you heroin, even though you will never love me back

 

[LucidSDreamr]

Yea, I won't use the same technique as our friend @DUMB ASS but yea @LucidSDreamr he is right. I've been reading your posts for a long time now. I really hate to see people who break free who get sucked back in. I know I spend too much time talking about Lord of the Rings and its relation to addiction, but you can all take it or get a new moderator.

When the war of the Grand Alliance defeats Sauron, all they have to do to rid the world of evil forever is to throw the ring into the fire. Thousands died, there was misery, pain, but they won the war that seemed completely unwinnable. It was a miracle. Then Isildur refuses to destroy the ring. He will use its power to make a perfect world he thinks. It's the same thought every man previously had had regarding the ring.

Once you've been a junkie or "Chronically Opioid-Dependent" with cycles of withdrawal interwoven, you're basically fucked man. You will never be able to "enjoy" using Opioids again without extreme peril. You're only going to be able to use for 3 days tops before you are basically right back where you started.

No, Buprenorphine shouldn't cause precipitated withdrawal unless an individual is physically dependent upon Opioids, if this is a one-time thing, this interaction shouldn't be relevant. It will become relevant if you end up doing this for longer than a couple of days though.

I fucking hate opioids and all they bring. You guys sound like squares saying that ppl on these fucking opioids are having fun and a big party…it’s miserable and the choice to take them is just trying to decide what’s less miserable; raw unmedicated physical pain or dependency. Dependency might be worse though to be honest at least for 85% of the pain o experience.

I’m running from physical pain not chasing a fun high.

I want to die and have begged my wife to prepare for it or leave me. So this is how dire it is to escape pain

If you don’t have chronic pain you don’t get it.


But I have been reflecting and despite all the recent pain I can’t let myself get dependent again be cause the process of withdrawl disrupts my life so severely and I have too much responsibility at this point in life.

 

[LSDiesel]

I love to hate it. I absolutely use it for both physical and emotional pain. Life without the fleeting relief acquired here and there doesn’t seem possible or realistic in any sense. I truly wish it wasn’t so dismal the “love and fun” aspects of opiates are merely in the sense that I find it fun to feel no pain and be numb. Over the years that became much more important to what I would consider to be recreational substances. Sure psychedelics and e offer incredible life experience milestone wowzers but as I aged any substance for it to be considered recreational by me at all would need to have some element of numbing or pain relief for me to consider it “fun”

Getting older dancing to music at live events for hours it certainly helped to numb up your feet and legs after doing it for so many hours so you couldn’t feel how sore you were really making your muscles

This was an early 30s phish show experience where I had a wicked good blasted time but this time it was heavily ketamine based I wouldn’t have needed such a numbing agent when I was 22 to dance for so many hours

I have used k and h/opiods while excercising to try to push my body to do more strenuous things that I might not handle well sober at times, then again each time I abstain for too long existence is what I am running from, i can’t accept this is how it is it’s only bearable by making new plans to escape it though medicine distraction and hedonism

 

[Señor Moreno]

2 mg of bupe with no tolerance is almost as good as any of the best opioids imo.

People are different, maybe you like bupe better, but I don't think that you will find too many people who would take a partial agonist over a full one, bupe over heroin as an example. Many people, myself included, find bupe to be a nasty drug and never liked it, but I get that you do and so do others

20 to 30 mg of methadone with no tolerance is alright but it’s just not warm in the way the thebaine/morohine family of opioids are and bupe is included.

30 mg of mdone with no tolerance seems a little overkill to me.

 

[LucidSDreamr]

People are different, maybe you like bupe better, but I don't think that you will find too many people who would take a partial agonist over a full one, bupe over heroin as an example.

i never said I prefer bupe over heroin or dilaided. I said with no tolerance, I would pick it over methadone, I would not pick it over heroin.

 

[Señor Moreno]

Well, you exactly said, word by word, that "2 mg of bupe with no tolerance is almost as good as any of the best opioids imo". And I can't agree.
But its ok anyway, people is different and drugs affects us in different ways. You are far from being alone in liking bupe, french users always have had have a taste for it.

People looks at me weirdly when I say that I like Demerol, but the thing is that I like it...

 

[Señor Moreno]

Oh, @LucidSDreamr, back to the topic of your thread, I have been reading weeks ago about Mauritius Islands, in the Indian Ocean, you know.
Apparently, heroin is big there. The report said that the islands are a main point of h distribution to South and S E Asia, aswell to other places.
Those islands are a true paradise, utterly beautiful beachs and all that. If on top of that they have avaliable good heroin, it could be the perfect destination.