N&PD Moderators: Skorpio | someguyontheinternet
I'm not sure about the potency of aniline ring substituted fentanyls I have seen a jannsen paper/patent somewhere that had fluoros on the aniline ring but I can't remember whether it was good or bad. I'm really not interested in opioids.mad_scientist said:(ii) also what about substitutions on the aniline ring of fentanyl? Would a meta-hydroxy group boost activity or is the conformation wrong? I guess it would be a bitch to make but you could use meta-methoxyaniline and then strip off the CH3 later maybe?