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Misc Armodafinal/Nuvigil prescribed off-label for migraines...

Where Wolf?

Bluelighter
Joined
Oct 30, 2006
Messages
484
Location
Sheol
Just wanted to see if anyone else has been prescribed modafinil or armodafinil for migraine prophylaxis. I suffer from sleep apnoea, so the modafinil prescription made some sense - but I didn't find it all that pleasant (or useful as a functional stimulant) - and while attacks decreased in frequency, it was at the expense of a lot of sleep: the stuff's almost as bad as amphetamines for rebound insomnia. Now I've been given armodafinil for migraines, and find that 8 hours after a low dose (50mgs) I experience quite marked mood-swings, tearfulness and a strong tendency to painful reminiscence.

I've stopped taking the stuff, of course, but has anyone else had a similar experience? I do get extreme symptoms, so I've been given everything from dhc + tryptans to pitzofiten and metoclopramide (I read the side-effects profile of those two and took them right back to the pharmacy untouched), so I'm not surprised they've tried multiple options - though sumatriptan + ibuprofen + dhc/codeine is perfectly effective. I'm actually considering flushing the remaining Nuvigil - combines all the worst aspects of both mild and low-dose strong stimulants, with none of the plus points.
 
Stimulants are a terrible idea for migraines. I hated pizotifen. It's rarely prescribed anymore. Have you tried trycilics? I'm on nortryptaline (high dose) and it's done wonders for me.

And opiates (DHC) can cause migraines. Is your doctor crazy?
 
Stimulants are a terrible idea for migraines. I hated pizotifen. It's rarely prescribed anymore. Have you tried trycilics? I'm on nortryptaline (high dose) and it's done wonders for me.

And opiates (DHC) can cause migraines. Is your doctor crazy?

Opiates can cause migraines - maybe increased cranial pressure? - but when an attack hits, they can also distance you from the pain. The most effective treatment, for me, has been sumatriptan + dhc + an anti-emetic (usually buclyzine) + low-dose NSAIDS. Believe me, when the right side of your head's about to explode and the sumatriptan didn't work (usually because you've taken it too late), 120 mgs of dhc chased with soda and migraleve (500 mgs acetampinophen/paracetamol, small dose of bucylizine + 8mgs codeine) makes the difference between sitting in pain in a dark room for half an hour till the meds kick in and losing a whole day to agony that straight-up Ibuprofen or acetaminophen/paracetamol barely dents: without an opiate at hand, there's the risk of incapacitation. I can't afford - literally - to be unfit for work, day to day. I'm in the EU, the economy's been bad for years, my field's competitive: and I'm freelance. Two-three times a year, attacks come in on a daily basis - sometimes 2/3 times a day. I don't have time to fuck around.

There's an offer of surgery that might ameliorate the problem, but it isn't guaranteed, and I'd have to walk around with my face bandaged for up to six weeks. Now, I'm not much to look at: but I think I'm better off, at meetings, not looking like a mummy. But to be honest, yeah, my doctor is fucking crazy. He wrote me stupid scripts till I caught him out in a few careless prescriptions without proper warning, and then he pretty much allowed me to treat myself (I know a few shrinks socially, I was primed on how to put it. If I'd taken the pitzofiten/metocolopramide cocktail he'd given me, I could have undergone extreme personality change, tremors, weight gain, aggression, depression and tardive dyskenesia, plus addiction to dysphoric meds. So I cornered him, and he accepted my opinions/preferences for a while...then read a few papers that claimed modafinil in moderate doses can treat sleep apnoea - which exacerbates migraines - and isn't strong enough to cause them. But I think, on reflection, I better find another doc - so thanks for responding, it was the push I needed. The worst thing about it all, and I realise this ain't exactly serious. is that I have all the classic migraine triggers: red wine, red meat, dark chocolate, tobacco.

I love to smoke, eat beef in many forms and prefer dark chocolate.

And can live with an excuse to take painkillers.

As to noratryptaline, I'm not familiar with it...and it makes me think of tryptamine anti-depressants, which I've seen zombify friends. But I'll look into it.

I guess I started this thread because I know my doc was following an increasingly widespread practice of using the modafinils for migraine purposes, because of their vasodilatory properties - sinus shit (like my nasal polyps) exacerbates migraines, throw in sleep anpnoea and low-dose kinda makes theoretical sense. But it sure hasn't worked for me, and I've needed benzos (migraine-neutral) when armodafinal wears off.

I'm a Jew. A fucking Jew. Could I bless red wine and bread and light the candles tonight? Nah, I had to drink white wine, or I would have been hitting max doses on ibuprofen just to get the codeine blended in these pills. Sorry to go on at such length: I'm lucky to be somewhere one can easily and legally be equipped to take quite large amounts of codeine and anti-emetics. But I tried the armodafinil this morning, and have finally decided it's completely useless. I hate throwing pills away, but these ones are going down the toilet.
 
It hasn't zombified me at all. It is an anti depressant but it works well for pain. And yes, I know what the pain is like. I'm a chronic migraine sufferer. You need to find a new doctor if you haven't been tried on preventative treatments which it sounds like you haven't. While the DHC may help at the time but it may also be to blame for the next headache. Most migraine sufferers are suffering really with medication induced miraine.

Before even thinking surgery trycilics and things like gabapentin should be tried. How common are the headaches? Have you seen a neurologist?

http://en.wikipedia.org/wiki/Nortriptyline

It has almost erradicated my headaches after 5 years of trying different meds and everyday pain.
 
About a year ago, I asked my long time psychiatrist for Provigil/modafinil.

He said he had just been messing with 3 different insurance companies that said the ONLY way Provigil would be covered is if the patient has been diagnosed with sleep apnea.

So yeah, off label, but you still fit the general criteria for the drug.
 
Sorry, madog11, of course you understand about the pain and nausea. Nortryptyline is, as I feared a tricyclic, and I don't trust anti-depressants of any kind - the increased risk of suicidal ideation frightens me with this one. There's been a lot of suicide in my family, so it's often on my mind as is. More thoughts of that kind I don't need.

I've tried gabapentin and pregabalin with some success, but they seem to work best at high doses and I can only get them as private prescriptions (they're not covered by our medical system here, and our national health system doesn't seem to know about them: I was met with a blank stare when I first asked - I'm sure the doc had never heard of them). Attacks come in clusters, for two-three periods a year of 3-weeks to a month or so, usually once or twice a day. I woke up with one beginning, this morning, and 400mgs Ibuprofen + 30 of codeine and 10mgs of diazepam (all I have) with strong coffee has more or less disposed of it. I just can't wait till this cluster passes - though at least it's kept my drinking down.

I haven't seen a neurologist, but I did get an MRI, which showed the polyps - that plus sleep apnoea are the primary physical cause. A steady or large supply of Sumatriptan would make life a lot easier, but they'll only ever prescribe me 12 x 50mgs a month, and at the moment, that just about gets me through a week.
 
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You need to get your doctor to transfer you to a neurologist. I found that GP's, even good ones don't prescribe nearly high enough doses because they are being too cautious. A neurologist will know better what meds will suit you and will put you on the actual dose you need. I can't believe you haven't seen one already. Surely some anti-epileptics are available not on private prescription over there? It sounds like they helped. It doesnt just have to be gabapentin.

I know you're frightened but tryciclic anti depressants and triptamine ones are very different. At least do some reading before dismissing it completely. It really has been a miracle drug for me (not saying it definately will for you but it's worth looking at).

http://en.wikipedia.org/wiki/Tryptamine

http://en.wikipedia.org/wiki/Tricyclic_antidepressant

I spent a lot of my time growing up very suicidal. And a lot of depressed people already are. The meds have that effect so rarely. They haven't increased my thinking about it. (I'm on an anti depressant sized dose but i'm not on it for any depression, probably should have been a few years back!).
 
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Sorry, madog11, of course you understand about the pain and nausea. Nortryptyline is, as I feared a tricyclic, and I don't trust anti-depressants of any kind - the increased risk of suicidal ideation frightens me with this one. There's been a lot of suicide in my family, so it's often on my mind as is. More thoughts of that kind I don't need.

I've tried gabapentin and pregabalin with some success, but they seem to work best at high doses and I can only get them as private prescriptions (they're not covered by our medical system here, and our national health system doesn't seem to know about them: I was met with a blank stare when I first asked - I'm sure the doc had never heard of them). Attacks come in clusters, for two-three periods a year of 3-weeks to a month or so, usually once or twice a day. I woke up with one beginning, this morning, and 400mgs Ibuprofen + 30 of codeine and 10mgs of diazepam (all I have) with strong coffee has more or less disposed of it. I just can't wait till this cluster passes - though at least it's kept my drinking down.

I haven't seen a neurologist, but I did get an MRI, which showed the polyps - that plus sleep apnoea are the primary physical cause. A steady or large supply of Sumatriptan would make life a lot easier, but they'll only ever prescribe me 12 x 50mgs a month, and at the moment, that just about gets me through a week.

I get cluster headaches: I'm sorry for your pain.
I don't have a dr. now..as I've gone back to school..and had to trade insurance for education.
hefty doses of caffeine, and any opiates I have laying around if i'm lucky enough, are what I have to help me now...
People who don't get these, could never understand.

token
 
I get bad migraines but I don't recall ever being prescribed either of those drugs for them. I have tried a whole lot of different treatments and the only one I find to help at is is relatively simple and healthy. Drink tons of water, don't eat any white flour, reduce or eliminate intake of wheat (eat other grains instead), avoid caffeine, reduce processed sugar, avoid MSG, avoid artificial sweeteners, avoid fluorescent lights, get some fresh air. Also avoid any foods/substances you notice seem to trigger the migraines, like for me raw onions are not good. Take Advil Extra-Strength Liqui-Gels (ibuprofen, but this type or the generic liqui-gels seem to be particularly effective and have far less stomach issues) and drink 2 (or more) glasses water immediately at onset of headache (but try not to take ibuprofen every day). Acupuncture can also be beneficial when done by someone who is very good at it.

Yeah it's not as easy as taking a bunch of drugs, but this has seriously worked wonders for me and I never had success with any prescription meds or any other OTC painkillers.

ETA: Also putting mint and camphor (available in ointments like Tiger Balm or Vick's Vapo-Rub, or in essential oil form) on your temples, forehead, base of head where it connects to neck or anywhere else that hurts can be helpful if applied when you have a headache. This seems to help at least to a degree for most types of headaches. But the best thing is preventing the headaches in the first place.
 
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I get bad migraines but I don't recall ever being prescribed either of those drugs for them. I have tried a whole lot of different treatments and the only one I find to help at is is relatively simple and healthy. Drink tons of water, don't eat any white flour, reduce or eliminate intake of wheat (eat other grains instead), avoid caffeine, reduce processed sugar, avoid MSG, avoid artificial sweeteners, avoid fluorescent lights, get some fresh air. Also avoid any foods/substances you notice seem to trigger the migraines, like for me raw onions are not good. Take Advil Extra-Strength Liqui-Gels (ibuprofen, but this type or the generic liqui-gels seem to be particularly effective and have far less stomach issues) and drink 2 (or more) glasses water immediately at onset of headache (but try not to take ibuprofen every day). Acupuncture can also be beneficial when done by someone who is very good at it.

Yeah it's not as easy as taking a bunch of drugs, but this has seriously worked wonders for me and I never had success with any prescription meds or any other OTC painkillers.

ETA: Also putting mint and camphor (available in ointments like Tiger Balm or Vick's Vapo-Rub, or in essential oil form) on your temples, forehead, base of head where it connects to neck or anywhere else that hurts can be helpful if applied when you have a headache. This seems to help at least to a degree for most types of headaches. But the best thing is preventing the headaches in the first place.

I tried cutting out migraine triggers etc, still wont drink regular coffee when I have a headache even though it has no effects on my headache. It took meds to get mine under control. I can't believe you haven't been tried on preventatives. It sounds like you have an incompetant doctor.
 
I tried cutting out migraine triggers etc, still wont drink regular coffee when I have a headache even though it has no effects on my headache. It took meds to get mine under control. I can't believe you haven't been tried on preventatives. It sounds like you have an incompetant doctor.

What I said was I don't recall being prescribed specifically modafinil or armodafinil. I have tried plenty of other meds.
Did you try cutting out wheat and drinking tons of water?
 
I don't need to. Because 1, i don't eat much wheat. 2, to see if it works it would mean coming off my meds that have stopped my headaches. I'm just not willing to do that when I have no other food migraine triggers, caffeine, chocolate, cheese, all of which i've tried going without.

My meds stop almost all of my headaches. And I have a great doctor and a seperate neurologist who never mentioned it. So for the tiny chance you might be right i would have a month of headaches. Sorry, but it's not worth it. I might try cutting out the very small amount of wheat I eat should I ever come off my meds.
 
^This.

Have you tried the triptan class of anti-migraine drugs? They are by far the most effective anti-migraine drugs on the market. I've tried, well, every migraine drug out there (with the exception of Cafergot) and the triptans blow everything out of the water. Even potent opiates (Demerol, hydromorphone, morphine) don't touch the triptan's ability to knock migraines down.
 
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