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Science Are there any BL scientists (ideally chemists) who are fluent in Japanese?

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3DQSAR

Bluelighter
Joined
Oct 27, 2024
Messages
395
I do appreciate that this is a very specific question but I am faced with the situation in which the only published work on a specific class of drug (14-methoxy morphinans) seems to have been carried out by Japanese researchers and with the best will in the world, even if I spend years assiduously studying Japanese, it's unlikely that I would be able to read a technical paper.

I'm not entirely certain that the compound I'm researching is even covered by the patent application I have found BUT I cannot discount the possibility. PubChem does reference the patent, but I'm not sure if THEY are mistaken.

Long story short. In the 70s Bristol-Myers developed the analgesic butorphanol. But they were VERY careful not to cover any analogues that may have been pure agonists. I mean, they avoided mentioning the N-methyl analogue which is almost universally used as a metric with which to measure analogues.

I'm even unable to identify the authors so I'm uncertain if any English-language papers exist.

It's at times like this that I realize just how ignorant I truly am.

Many thanks.
 
Uh I can read hiragana and katakana. I really struggle with writing in the one that is formal. If you like post it i could translate it. I used to do international business with japan so I had to email in japanese and use .jp websites.
 
3DQSAR said:
I do appreciate that this is a very specific question but I am faced with the situation in which the only published work on a specific class of drug (14-methoxy morphinans) seems to have been carried out by Japanese researchers and with the best will in the world, even if I spend years assiduously studying Japanese, it's unlikely that I would be able to read a technical paper.

I'm not entirely certain that the compound I'm researching is even covered by the patent application I have found BUT I cannot discount the possibility. PubChem does reference the patent, but I'm not sure if THEY are mistaken.

Long story short. In the 70s Bristol-Myers developed the analgesic butorphanol. But they were VERY careful not to cover any analogues that may have been pure agonists. I mean, they avoided mentioning the N-methyl analogue which is almost universally used as a metric with which to measure analogues.

I'm even unable to identify the authors so I'm uncertain if any English-language papers exist.

It's at times like this that I realize just how ignorant I truly am.

Many thanks.
Click to expand...

If it’s a Japanese patent you can search its number on WIPO or the EPO patent websites and see if there is a corresponding English family member. Most inventors also file concurrently in at least the US.
 
It's rare but not unique for a Japanese paper to ONLY be available in Japanese. The reason being that English is generally accepted as the lingua franca for sciences. So it's quite possible that thee IS en English language version if you know where to look.

A German chemist, Hemut Schmidhammer published about a dozen papers on 14-methoxy morphinans. It was a while ago so maybe the Japanese have something new, but Schmidhammer was pretty exhausive.

If we knew what it was, we might be able to find the English languave version for you.
 
3DQSAR said:
I do appreciate that this is a very specific question but I am faced with the situation in which the only published work on a specific class of drug (14-methoxy morphinans) seems to have been carried out by Japanese researchers and with the best will in the world, even if I spend years assiduously studying Japanese, it's unlikely that I would be able to read a technical paper.

I'm not entirely certain that the compound I'm researching is even covered by the patent application I have found BUT I cannot discount the possibility. PubChem does reference the patent, but I'm not sure if THEY are mistaken.

Long story short. In the 70s Bristol-Myers developed the analgesic butorphanol. But they were VERY careful not to cover any analogues that may have been pure agonists. I mean, they avoided mentioning the N-methyl analogue which is almost universally used as a metric with which to measure analogues.

I'm even unable to identify the authors so I'm uncertain if any English-language papers exist.

It's at times like this that I realize just how ignorant I truly am.

Many thanks.
Click to expand...
Can you link the paper?
 
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