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Anyone use ibuprofen or another anti-inflammatory chronically or long term? What dose and how is it?

JohnBoy2000

JohnBoy2000

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I believe it's use is intended to be confined to 10 days in adults, unless prescribed by a Dr.

Max dose 3200 mg/day (which is a lot).

Used chronically it can deprive certain areas of blood flow (such as the inner ear), causing tinnitus (which sucks).

Unsure of the frequency with which that happens however.

I believe it inhibits prostaglandin production, which is normally responsible for inflammation.

But anyone use it long term and any side effects, concerns, thoughts, experiences etc?
 
I've used naproxen longterm (15 years) but low dose and quite rarely, I'll go for an average of maybe 500mg (250mg sometimes) twice a week

It's easier on my stomach than ibuprofen (but can still mildly irritate it on occasion), and definitely helps with inflammation and associated pain a little (but then again, so does a hefty multiple-capsule dose of Turmeric).

I did develop mild, sometimes moderate tinnitus around 8 years ago too, but I suspect loud music exposure for a few decades to be at play here, perhaps combined with the blood-pressure spikes caused by the rapid absorbtion of nasty drugs via roa's which facilitated that rush dunno. Maybe the naproxen was in the mix, seems the least likely culprit in my case but who knows
 
I would say 4 × 200 mg Advil / Motrin (ibuprofen) is about as much Advil as I would feel safe taking for pain per day.

Advil is one of the best of the NSAIDs (non steroidal anti inflammatory drug) pain relievers. It is pretty much 100% non psychoactive, but if anemia is an issue, use it sparingly.
 
I take 400 mg x 3 daily! Thats two tablets x 3, and that is a small dose, basically it amounts to one prescription strength and a quarter prescription strength, I cannot imagine any serious long term issues from such, and I have been taking this amount daily for years!
 
I take ibuprofen almost every day. Usually 800mg 2-3 times daily. It's been fine for me. I've been doing it for years. I sometimes use naproxen instead 440mg 2 times a day. It's actually in my medical history that I am a long term user of nsaids. I've never had the stomach issues or bleeding.
 
Long term main issues are stomach and kidneys.

Stomach is due to decreasing the amount of pH-buffering mucus being produced to protect your stomach from the acid and enzymes. Antacids can help with this.

The kidneys get hurt because blood flow decreases to them. This is a slower and more chronic process, and unfortunately one harder to mitigate.

Probably not worth freaking out over, but definately pay attention to creatinine clearance and BUN readouts when you get labs, and stop immediately if kidney issues occur.
 
Curious if ibuprofen and similar drugs are most recommended for dental pain?

400 mg makes things a lot easier, it's tinnitus worsening I'm concerned with though.

Also, something is giving me nasty dry mouth and dried out mucus membranes, no idea what.

It's hardly ibuprofen?
 
JohnBoy2000 said:
Curious if ibuprofen and similar drugs are most recommended for dental pain?

400 mg makes things a lot easier, it's tinnitus worsening I'm concerned with though.

Also, something is giving me nasty dry mouth and dried out mucus membranes, no idea what.

It's hardly ibuprofen?
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Long term or short term?
 
Survival0200 said:
Yes. Naproxen and diclofenac also. Depends on the dentist what they prefer.
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Think I used naproxen by the brand "vimovo".

Actually I found it weaker compared to ibuprofen, but maybe that was cause of the dose (though it said 1 tablet per day).

Diclofenac I think may be for shorter term use cause it dramatically increases the risk of cardiac events according to studies?

Good to know all my bases are covered though.
 
I also take ritalin in the morning, which is very good for alleviating the nerve pain in this pulsing tooth.
That gets me through the day, using the anti-inflammatory for the night.

Dr said he'd be open to prescribing "Nortriptyline", the old tricyclic, but I'd been on lofepramine before (70 mg, lowest dose), and it was horrible and nasty. Heavy cardiac effects due to muscarinic acetylcholine blocking.
 
I have been taking ibuprofen several times a month (600mg during periods of 2-3 days) for about six years now. Interestingly, the reasons I was told to take them is because I have tinnitus from chronic sinus issues.
 
JohnBoy2000 said:
Dr said he'd be open to prescribing "Nortriptyline", the old tricyclic, but I'd been on lofepramine before (70 mg, lowest dose), and it was horrible and nasty. Heavy cardiac effects due to muscarinic acetylcholine blocking.
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The adverse cardiac side-effects with this medicine only occur prior to building up a tolerance. Once you get used it, it will not affect you at all.

The only tricyclics I have tried are amitriptyline and imipramine though. I do not know if nortripyline is substantially different from amitriptyline or if they are the same sort of thing. I know they look very similar but I recall reading somewhere that desipramine was substantially different from imipramine, although this was not based on subjective accounts, rather the binding in vitro to the SER/NE transporters.
 
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