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Opioids Any way to make codeine more potent

benzolover101

benzolover101

Bluelighter
Joined
Dec 27, 2024
Messages
31
How can I make a more euphoric feeling from like the first time I had codeine. I take now 8-10 30mg codeine tablets to hit that mark I was upon first taking it.
Anything around the house would help?
Something without having to go the pharmacy to buy something to add to it.
Any ides ?
 
Glutethemide/it's close analogs are said to make it feel like heroin because of how well it induces cyp2d6, but they're real hard to get. Promethazine is said to have similar qualities. Other than that, supplements might make it better. Some I like to take are dpla, turmeric & blackpepper, corydalis, valerian & hops, magnolia, cats claw, magnesium, skullcap... kratom might be a better bet, I feel like the ceiling dose (and obv price) is much better for abusers of the substance despite it being a partial agonist.
 
I would be vary careful when considering analogues of glutethimide. While para-amino glutethimide is used medically, it's used as a treatment for specific cancers. When a drug is used such a dangerous disease, toxicity is considered an acceptable risk.

While a couple of related compounds are, like glutethimide known to be CYP2D6 inducers, they are less effective in this role, are very old medicines and thus their safety profiles are not well known.

What I would like to know is if it's just one isomer of glutethimide or both or a metabolite since the two isomers undergo different metabolic pathways.

It's one of those things that was never studied at the time and given that glutethimide is no longer used medically, it's unlikely anyone will ever know which species is/are responsible for the enzyme induction.
 
benzolover101 said:
How can I make a more euphoric feeling from like the first time I had codeine. I take now 8-10 30mg codeine tablets to hit that mark I was upon first taking it.
Anything around the house would help?
Something without having to go the pharmacy to buy something to add to it.
Any ides ?
Click to expand...
Buy some cyclizine online, take 50-100mg before you take the codeine. Or grapefruit but not if you're on anti-depressants
 
Cyclizine is an opiate potentiator so basically makes any opiate you feel like you're on double the dose you took while also being an anti histamine and anti nausea med so no vomiting or itching. It's amazing mixed with any opiate and totally legal.

I've never read the book but I can imagine it's a good book.
 
low dose dxm potentiates opiates, or both drugs potentiate each other... with the more dxm you take the less like an opiate buzz it will be... like even a standard dose for a cough could increase the effects of an opiate a little bit ime... when i got my wisdom teeth removed, i drank a bottle of robitussin slowly through out the weekend with the pills.. it seemed to increase the feelings... i often hear about dxm and opiates, have done it some other times, but like i said, the more dxm you take the more dxm buzz you'll feel too, which isn't really like opiates.
 
3DQSAR said:
I would be vary careful when considering analogues of glutethimide. While para-amino glutethimide is used medically, it's used as a treatment for specific cancers. When a drug is used such a dangerous disease, toxicity is considered an acceptable risk.

While a couple of related compounds are, like glutethimide known to be CYP2D6 inducers, they are less effective in this role, are very old medicines and thus their safety profiles are not well known.

What I would like to know is if it's just one isomer of glutethimide or both or a metabolite since the two isomers undergo different metabolic pathways.

It's one of those things that was never studied at the time and given that glutethimide is no longer used medically, it's unlikely anyone will ever know which species is/are responsible for the enzyme induction.
Click to expand...
And thalidomide is the drug that glutethimide came from. Risky to say the least
 
foodcrisis said:
low dose dxm potentiates opiates, or both drugs potentiate each other... with the more dxm you take the less like an opiate buzz it will be... like even a standard dose for a cough could increase the effects of an opiate a little bit ime... when i got my wisdom teeth removed, i drank a bottle of robitussin slowly through out the weekend with the pills.. it seemed to increase the feelings... i often hear about dxm and opiates, have done it some other times, but like i said, the more dxm you take the more dxm buzz you'll feel too, which isn't really like opiates.
Click to expand...
DXM Is more like a SNRI version of PCP. Your better off doing DPH at 50 ~ 125mg with a Opioid.
 
daturetard said:
Glutethemide/it's close analogs are said to make it feel like heroin because of how well it induces cyp2d6, but they're real hard to get. Promethazine is said to have similar qualities. Other than that, supplements might make it better. Some I like to take are dpla, turmeric & blackpepper, corydalis, valerian & hops, magnolia, cats claw, magnesium, skullcap... kratom might be a better bet, I feel like the ceiling dose (and obv price) is much better for abusers of the substance despite it being a partial agonist.
Click to expand...
Turmeric and codeine would intensify codeine?
 
benzolover101 said:
Turmeric and codeine would intensify codeine?
Click to expand...
With black pepper, it should. Turmeric has very weak effects on the u opioid receptors as an agonist, I'm almost certain that's why it's anti-inflammatory and analgesic. The body clears it too fast (ei; poor bioavailability), but piperine from (whole seed) black pepper should inhibit its breakdown. (Said to boost curcumin absorption 2000%)
https://pubmed.ncbi.nlm.nih.gov/19070135/ https://www.sciencedirect.com/science/article/abs/pii/S0143417922000932 Also look into blackseed oil too.
3DQSAR said:
I always look for CYp2D6 inducers - do you have a reference for that. I did perform a search before asking.
Click to expand...
Ik the cyp2d6 wiki it said the only two known pharmaceutical inducers are glutethemide and haloperidol, the later of which is also said to be an inhibitor as well. There are certainly more inducers used for purposes that make the activity there irrelevant.
 
Medicine as a whole has been searching for CYP2D6 inducers as there is medical utility. It's sort of been declared a difficult enzyme to induce.

Genetics appears to play a much larger role hence the possibly medical utility of a new inducer - to ensure a reliable response

To the best of my knowledge ONLY glutethimide (or a metabolite - nobody has actually tested that hypothesis) is classed as being a potent CYP2D6 inducer.

A few others are mentioned but nobody has ever measured how active they are. There are some old medicines related to glutethimide that have SOME induction activity, but nobody has studied them.
 
Back in the days - late 90s I was addicted to codeine and glutethemid for 2-3 years. When I didn’t have glutethimid I was using tardil, fenobarbital or hexadorm instead but non of them was giving the same effect as glutethimid. Anyway each one of them was potentiating codeine pretty good. BUT !!!!!!! You must be really careful with these pills.
 
tardil? hexadorm? Can you provide the CAS number of these medicines or at least the name of the active drug so we can be certain of which we talk. Thanks,

I'm guessing fenobarbital = phenobarbitone...

Phenobarbitone is still in use and no mention of CYP2D6 induction but there is a clear warning that codeine can lead to enhanced CNS depression. That said, it's often people reporting that leads to such discoveries.

If you have references, I would love to read them. If glutethimide AND phenobarbitone do cause CYP2D6 induction then we have some key moieties, especially if hexadrom is a brand-name for hexobarbital. That might suggest that it's a metabolite of glutethimide which would open the door to designing a compound that would bnot e psychoactive if used alone BUT would make codeine (and I suspect dihydrocodeine, hydrocodone and ocycodone) far more active.

Thanks for the notes.
 
Last edited:
I got hexobarbital but we need conformation.

But if the 4-aryl-4-alkyl are key then I take that as a good sign.
 
Hexadorm calcium- cyclobarbital- CAS:52-31-3
Tardyl- amobarbital- CAS:57-43-2
It’s phenobarbital- [Phenobarbital CIV (200 mg)] - CAS [50-06-6]
 
Odd that there is no reference to enzyme induction for those barbiturates. Now most barbiturates were largely replaced by safer, more modern drugs by the time the activity of glutethimide was properly establishes.

But phenobarbitone (in the UK often referred to as phenobarbital) IS still in use for certain types of epilepsy.

But I can't find any references suggesting it's a CYP2D6 inducer... which isn't proof of absence.
 
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