anxiety; links to ssnri's and Ampphet meds

[EllisD.yeahit'sme.]

anxiety; links to ssnri's and Amphet meds

yessum, so...

For a good while now, I've been prescribed to

adderall xr-30mg
cymbalta-60mg
xanax xr- 3 mg
and seroquel 200mg

During the time period i've been prescribed such meds, i've noticed a definite increase in essentially all the physiological symptoms of anxiety....markedly with increases in peripheral cns stimulation that i attributed to the l-amp isomer is the adderall....

anyway, i decreased the dose from that....

peripheral cns uncomfortabilty still occurring....my psych said the problem was more than likely an early onset of tardive dyskinesia, and i argued with him that that probably wouldn't account for the peripheral increases in anxiety symptoms that have begun to incapacitate me....

so we stopped the seroquel...

and then i was thinking. Cymbalta is an ssNri. emphasis on the inhibition of noradrenalin reuptake..

this, combined with the amphetamine would, in my theory, would account for a large percentage of my anxiety issues...

I discontinued, for two weeks, the adderall. anxiety definitely decreased, but was still suffering from it. next two weeks, i started back on the adderall, and ceased the cybalta. definite increase in anxiety, but not as marked as with the combination.

bringing this up with mu doctor yesterday, he told me that he really didn't know, and hadn't done any research on the subject. 8)

what do you guys think? any and all input welcome. but please, wipe your feet,

 

[fastandbulbous]

^ What do I think...

bringing this up with mu doctor yesterday, he told me that he really didn't know, and hadn't done any research on the subject.

I think that money is the motivator. I've just asked my wife about that list of prescribed medicines (she works at Poisons/Medicines Info Unit), and she agreed with me that there is NO logic behind that combination.

Seroquel and amphetamine have totally opposite actions, w.r.t the CNS

Newer or atypical antipsychotics are effective in the treatment of positive symptoms and claimed to be effective in the treatment of negative symptoms:_
clozapine (Clozaril)
risperidone (Risperdal)
olanzapine (Zyprexa)
quetiapine (Seroquel)
amisulpride (Solian)
zotepine (Zoleptil)
ziprasidone (Zeldox) Launch date: Summer 2001
These drugs block dopamine transmission but also affect serotonin transmission. For this reason it is claimed that these drugs have beneficial effects on the negative symptoms of schizophrenia. They cause less extrapyramidal side effects and therefore can be used in patients who are unable to tolerate the older antipsychotics.

www.napier.ac.uk/fhls/commhealth/PSYCHOTROPIC2.doc+seroquel+%22mode+of+action%22&hl=en]From Edinburgh Healthcare NHS Trust[/URL]

Cymbalata and amphetamine are, as you pointed out, going to increase noradrenergic activity, of which the most noticable effect is anxiety, so they try to deal with that by prescribing a shitload of an benzodiazepine (Xanax).

Just what exactly are they supposed to be treating you for? Whatever it is, they're going to turn you indo a benzo dependant person at the very least.

Refs for above

http://www.esmind.org.uk/Texts/quetiapi.htm

http://www.esmind.org.uk/Texts/antipsyc.htm

http://scholar.lib.vt.edu/theses/available/etd-02052001-120403/unrestricted/finalthesis.pdf.

I know that all the refs bar one are from NHS (UK) sources, but in the UK, we don't have to pay for medical care (well we do, but through Income Tax) so money isn't a motivating factor; the patients treatment/healthcare is the primary concern, unsullied by things like making a profit

 

[i are spectre]

i had bad anxiety problems with strattera and adderall, but not cymbalta which im on now and im going back on adderall xr friday. how long have you been on those meds? maybe it's anxiety caused by something other than those drugs, perhaps another drug or just something that occured in your life recently. im on a smaller dose of cymbalta (30mg) though.

 

[EllisD.yeahit'sme.]

well my best friend committed suicide february 16th, so that's not helping things much.

and thank you fastandbulbous. you were right about the r-bdf-d (benzodiflouran) and you're right about this.

i originally started seeing this doctor when i was on probation and needed amphetamines to help me study (well, wanted) and for an anxiety disorder that had been plauging me for years. anxiety's still here, unfortunatly, i still occaisionally have to take the amphetamine, but i drop out much of the contents of the pill to keep my hppd to a minimum (amps induce a psychotic reaction in me). the seroquel is to fight any neurosis that develops from the amps, and top help me sleep. taken in the p.m.



thanks again everyone!

 

[BilZ0r]

Saying that amphetamine and seroquel have completely opposing actions is a bit of an over simplification isn't it?

The combination does seem very odd none the less.

What do you mean when you say peripheral CNS, and talk about peripheral effects?

Mixing amphetamines with uptake inhibitors is a bad idea, generally... but more because they oppose each others actionsl. They don't generally potentiate each other.

 

[Dope_User]

As I see it, you have several options. If you think the NA reuptake inhibition from Cymbalta is increasing your anxiety, consider switching to an SSRI instead. If you think the l-amp is increasing anxiety, ask your doc if you can try dextroamphetamine instead. I'd recommend against increasing the Xanax XR due to dependence issues. You could always maybe lower the Xanax XR to 2 mg per day and if you get anxious, take regular Xanax (.5-1 mg per day) but only if needed. I don't see as much of a problem as others with respect to the Seroquel, as long as it is helping you sleep. You may just want to try decreasing dosages of the Cymbalta (down to 30 mg/day) and switching to d-amp at a lower dose. As my doc does, you should ALWAYS make one switch at a time and give it enough time so you can see what effects are a result of the change you made. Then you can go ahead and make a second (or third or fourth) change if necessary. Mental illness of any kind can be extremely difficult to treat and often requires lots of time and possibly many different combos of meds. Good luck.