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Mental Health Antipsychotics have shut down my dopamine system

Crowley666

Crowley666

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Joined
Aug 29, 2019
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5
I am Bipolar I was placed on Olanzapine. Now I am on lamotrogine which is luckily not an antipsychotic but I'm still having problems from the olanzapine. The Olanzapine completely shut down my dopamine system so if I do coke or meth I feel absolutely nothing. How do I return my brain to normal? It's been 3 months and I still feel absolutely nothing. Are there any supplements I can use?
 
This could take years to come back to normal. Its quite possible that it will never be the same again. I took antipsychotics for a few months and dopamine drugs dont affect me in the same way anymore.
The best thing would propably be to forget meth and coke. There has been some talk about supplements on this forum, you could check out the "coming off of invega" thread.
Hope you get better.
 
Thanks. I don't care for coke. But Tina I used to orally dose in sub 10mg doses for low sex drive and my partner has a higher sex drive than me and I'm just not horny enough most of the time. I did look into GHB which is supposed to help with sex drive. But I'm just struggling because Viagra doesn't help with lower libido. I don't have ED just low libido. I wonder if the parkinsonian dopamine agonist drugs can reverse the damage to my dopamine system.
 
Crowley666 said:
Thanks. I don't care for coke. But Tina I used to orally dose in sub 10mg doses for low sex drive and my partner has a higher sex drive than me and I'm just not horny enough most of the time. I did look into GHB which is supposed to help with sex drive. But I'm just struggling because Viagra doesn't help with lower libido. I don't have ED just low libido. I wonder if the parkinsonian dopamine agonist drugs can reverse the damage to my dopamine system.
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Im interested also about those parkinson meds. I read they reverse the effects established on the brain by antipsychotics, so I am fairly sure they would work.

Btw about sex drive... have you considered about doing things you and your partner have not done? The brain is weird that way and I believe people have potentially unlimited amounts of possibilities with trying new things.
 
Crowley666 said:
I am Bipolar I was placed on Olanzapine. Now I am on lamotrogine which is luckily not an antipsychotic but I'm still having problems from the olanzapine. The Olanzapine completely shut down my dopamine system so if I do coke or meth I feel absolutely nothing. How do I return my brain to normal? It's been 3 months and I still feel absolutely nothing. Are there any supplements I can use?
Click to expand...
Same here wtf I can only get high from meth if I take 5-7 days off of meth , but before invega I could get high repeatedly for 5 days straight before I ran out of dopamine now I can only get high 1 day then my dopamine gone and I have to take another 7 day break
:( I'm going to sue the shit out of the maker of Invega.
 
It will take time to heal but there is a good chance that in time your dopamine will turn back on. I would suggest supplements like tyrosine to help kickstart the process.

Search the web for ways to improve dopamine production. Diet, exercise, and supplements will all help you heal quicker.

@Isnortice91 I would love to hear how that works out for you. You plan on suing a company because you took their product and now you have to take breaks in meth binges to get high? 😂😂🤣🤣 good luck with that bro! Did you ever consider the reason you dont get as high for as long is actually because of tolerance and long term heavy abuse of meth causing damage to your dopamine production and receptors? Considering that meth does this in all heavy users, I would suggest you reevaluate your situation.
 
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I'm only 5 month user. And I know people who arnt on Invega but get high just from taking a day off. And some don't even take days off and still get euphoric high. I want to get off of Invega because is cuts you're dopamine to 50 %. Which means where the fuck is my other 50?.
I want my old brain back . Yeah the reason they put me on Invega ,now that I think of it the head owner of the facility I go to is Jewish and I told my therapist and doctor that I admire the Axis powers from WWII. And ever since I said that they put me on this injection. Before the injection I could read Mein Kampf for hours and be fascinated about Hitler and WWII now since the injection reading just seems boring and not interesting as it once was. And in the facility I go to get the injection all the top doctors are Jewish.
 
Isnortice91 said:
I'm only 5 month user. And I know people who arnt on Invega but get high just from taking a day off. And some don't even take days off and still get euphoric high. I want to get off of Invega because is cuts you're dopamine to 50 %. Which means where the fuck is my other 50?.
I want my old brain back . Yeah the reason they put me on Invega ,now that I think of it the head owner of the facility I go to is Jewish and I told my therapist and doctor that I admire the Axis powers from WWII. And ever since I said that they put me on this injection. Before the injection I could read Mein Kampf for hours and be fascinated about Hitler and WWII now since the injection reading just seems boring and not interesting as it once was. And in the facility I go to get the injection all the top doctors are Jewish.
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How about that - anti-psychotics cure meth addiction AND nazism!
 
I would like to have known you before you started hitting the ice just to know what role it plays in your thoughts. My theory is that ice really brings out what is naturally in a person (except for psychosis which is mainly the lack of sleep not the drug itself and produces non-natural behaviours). But you also don’t seem like a person who believes in industrial scale murder and total state control over all aspects of society and thought. Your experiences of the legal system would be something quite common to socially undesirable people under Nazism - it was not all pretty uniforms and blitzgrieg.
 
Crowley666 said:
I am Bipolar I was placed on Olanzapine. Now I am on lamotrogine which is luckily not an antipsychotic but I'm still having problems from the olanzapine. The Olanzapine completely shut down my dopamine system so if I do coke or meth I feel absolutely nothing. How do I return my brain to normal? It's been 3 months and I still feel absolutely nothing. Are there any supplements I can use?
Click to expand...
Back to the OP. I have had problems with seroquel making meth unworkable at any dose. When I switched to Abilify I got the anti-psychotic benefits I needed for bi-polar but meth still worked (but coke did not). I don;t get the full euphoric high I would if totally clean of anti-psychotics but I definitely get all the horniness I can handle. I still use seroquel to clean up my act when meth gets too much and I have trouble stopping though.

One thought is that you you might need a bigger dose to cut through the anti-psychotics to get the horny effect you need. I find horniness is there at high doses but well before unpleasant over-amped side effects begin because of the tolerance reduction created by the anti-psychotics.

I think the horniness effect and and the euphoric effect and the tolerance level all work slightly differently in practice and ‘total dopamine depletion’ might not be sufficiently complex explanation for what is really going on.
 
I'm coming up on 2 years no seroquel/mood stabilizers and just recently began feeling a rebound in dopamine and emotion. I went through a period of time being on seroquel, lamictal, mirtazapine, wellbutrin, gabapentin, and other psych meds combined or one after the next within a period of a few months. I also feel that adding naltrexone was the nail in the coffin.

I've tried 5htp, GABA, ashwagandha + other minor gaba agonists such as chamomile, hops, and lemongrass. The difference is very very subtle but I think they help. I still take them now. What I found most beneficial however was adopting a more structured way of life along with practicing mindfulness.

Of course I don't know anything about your life structure or support system, but I've found those things paramount to keeping my sanity and dealing with my crippled emotional system.
 
I took Quetiapine (Seroquel) for about 6 months maybe longer and when I stopped taking it I didn't notice any dopaminergic impairment, I took Coke once about a month after I stopped the Quetiapine and the Coke was just as strong as it was before. Quetiapine is an atypical antipsychotic, im not sure what Olanzapine is I think its the same. I highly doubt you've permanently damaged ur dopamine neurons otherwise if u did then you'd quite certainly have more noticeable symptoms! Do you get any pleasure out of eating food, having sex, or achieving anything significant?
 
You need to take a high Tyrosine diet because Tyrosine is the precursor chemical needed by ur body to synthesize Dopamine. Try that for a month or two.

"Tyrosine, which can also be synthesized in the body from phenylalanine, is found in many high-protein food products such as chicken, turkey, fish, milk, yogurt, cottage cheese, cheese, peanuts, almonds, pumpkin seeds, sesame seeds, soy products and lima beans, but also in avocados and bananas."
 
I don't know why everyone is assuming it must be permanent. Antipsychotics antagonise dopamine and serotonin receptors which, yes, will make it feels like your dopamine reward system is fucked. While it may take the brain a while to fully recover after being taken off such medication, there's no reason to believe it never will.

Lamotrigine, which OP is currently on, does not inhibit serotonin and dopamine receptors strongly (although it does have weak action in these sites) but it is a sodium and calcium channel blocker. As a result it does inhibit glutamate at the striatum, which as it turns out is a vital part of your brain's reward system. Your brain needs both dopamine and glutamate to have a fully functioning reward system.

And yes, accordingly, stimulants such as amphetamine and cocaine exert their effects through modulation of glutamate as well as dopamine. So OP's stims not working makes perfect sense.

I would suggest it is far more likely that this pharmacological action from the lamotrigine is causing OP's continued apathy than some type of permanent dopamine deficiency somehow caused by an antipsychotic he stopped taking three months ago.

Of course OP hasn't been active since last year, so why did I write this? I dunno man. Amphetamine. I feel like this shit increases my IQ by 50 points. It doesn't, but it feels like it.

Hopefully this info useful to anyone with a similar issue who comes across this thread though. If you are on a medication that does not strongly inhibit dopamine, but you still feel loss of motivation or lack of effect from stimulants similarly to what you'd expect if your dopamine activity was reduced, you should also check out the effect of that med on glutamate.
 
Coffee is no help. Cocaine is alright. These with APs in my bod.
 
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