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  • BDD Moderators: Keif’ Richards | negrogesic

Antipsychotic dosage and comparison

A

Anon54

Ex-Bluelighter
Joined
Jun 11, 2010
Messages
861
firstly id like to say i dont know how i would cope without these drugs atm. they're like stronger versions of the otc sedating antihistamines & have cured years of unessasary insomnia. Something that benzos can only barely help unless taken in insane & dangerously addictive quantities.

antipychotics arnt the nicest feeling drugs in the world but i think they get a bad wrap they dont deserve.

Does anyone know the dose of which seroquel starts working as an antipsychotic & now just a sedating antihistamines?

Are all antipsychotics also antihistamines?

I've added a few links to to help people learn about the different side effects of the antipsychotics listed incase they're confused which ones will best suit themselfs.
http://drofrx.com/Diseases_files/RX files/Antipsychotics.pdf
http://www.psychresidentonline.com/atypical antipsychotics.htm


Heres some info on the ones ive tried

Olazapine makes me feel very heavy but has a cleaner tired feeling than Quetiapine. Probem being its duration is something like 16 hrs so ya feel tired half the next day.
Also makes me wanna eat alot.

Quetiapine doest make me feel as heavy & gives mild visual disortions. Even some CEV occationally in high doses. Makes my heaed spin like when i first started smoking. bit like a dissasociative. Seems more sedating & the good thing is it seems to have worn off after 8 hrs.

Rispiradone. Took it. didnt feel a thing must not have taken a high enough dose. I know Olanzapine & Seroquel are suppose to be equally sedating with clozapine the only stronger one & Rispiradone being the weakest of the 4.

Theres a few other commenly presribed antipsychotics. & id like ot here ppl experiences with em. side effects, duration of effects, sedation level etc.
 
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yea, psycopath is right. Seroquel at 25 mg should be tops for insomnia cure until tolerance develops (not sure how long). Staying low decreases your chances of feeling groggy as hell the next day. Was prescribed 25 mg long ago for sleep, worked great. I tried 50 mg once, wasn't tired.
 
posted in the linkpsycopath gave me was quoted from of the treads

-50 for sleep, up past 100 its a DA2 blocker, and may worsen your insomnia due to akatisa and dyskenesia associated with all antipsychotics, granted seroquel is known to be light on such side effects, they can still manifest.
Click to expand...

so takig more than 100mg will lesson the sedation?... & ive been taking 200mg probably why i still ant get to sleep


ehh i dont by into that BS. how can less than 100mg be more sedating than 300mg
 
Years ago, the first time I took Seroquel, my dumbass did like 200mg. They were "small little white pills" so why not pop two? Well here I am half an hour later with my heart racing and about to seek medical attention if it didn't get better. Then, I woke up the next morning. I don't recall trying to lay down and sleep.

I did do too much for a first timer. It made me almost have a panic attack for a while, then you get knocked the fuck out. I coulda had the same effect with just 25mg 8)

Then I learned that seroquel is some powerful shit!

Sometimes you just get lucky and get by without having to cause a scene. It obviously wasn't the smartest thing to do, I did emphasis "years ago".
 
DosageTo treat bipolar or schizophrenia, AstraZeneca recommends using 200–800 mg a day range, split into two or three doses a day. Seroquel extended release (XR) form can be taken once daily. Safety or effectiveness of low-dose use (<200mg) hasn't been established in clinical trials.

At very low doses (<25 mg), quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker. When the dose is increased quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. At high doses (over 250 mg) quetiapine starts blocking significant amounts of dopamine receptors.[16][17] DosageTo treat bipolar or schizophrenia, AstraZeneca recommends using 200–800 mg a day range, split into two or three doses a day. Seroquel extended release (XR) form can be taken once daily. Safety or effectiveness of low-dose use (<200mg) hasn't been established in clinical trials.

At very low doses (<25 mg), quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker. When the dose is increased quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. At high doses (over 250 mg) quetiapine starts blocking significant amounts of dopamine receptors.[16][17] Use of low-dose Quetiapine (<150mg/day) is not recommended except temporarily during drug titration period (less than 30 days).[18]
.[18]
Click to expand...

i dont understand why its not recommdended to take less than 150mg a day for a month.

Ive read conflicting info on the internet regarding the antipychotic dose of seroquel. some say only 100mg but like wiki has stated above, doses over 250mg
so does anyone actually know the dose or are these websites just guessing
 
If you had continued to read the thread I linked to, you would have read that "It's around 100mg where the antihistamine effects start to be overpowered by the DA2 blocking effects, as rangrz mentioned. Probably best to stay in the 25-75mg range for sleep." Past 100mg is more likely used for treating psychotic symptoms.

This was posted by the moderator. Typically a good source.

We posted at the same time. Wikipedia is typically accurate.
http://en.wikipedia.org/wiki/Reliability_of_Wikipedia#Assessments
I know it is from wiki, but they use 178 outside sources.
 
Anon54 said:
firstly id like to say i dont know how i would cope without these drugs atm. they're like stronger versions of the otc sedating antihistamines & have cured years of unessasary insomnia. Something that benzos can only barely help unless taken in insane & dangerously addictive quantities.

antipychotics arnt the nicest feeling drugs in the world but i think they get a bad wrap they dont deserve.

Does anyone know the dose of which seroquel starts working as an antipsychotic & now just a sedating anthistamine?

Are all anitpsychotics also antihistamines?


Heres some info on the ones ive tried

Olazapine makes me feel very heavy but has a cleaner tired feeling than Quetiapine. Probem being its duration is something like 16 hrs so ya feel tired half the next day.
Also makes me wanna eat alot.

Quetiapine doest make me feel as heavy & gives mild visual disortions. Even some CEV occationally in high doses. Makes my heaed spin like when i first started smoking. bit like a dissasociative. Seems more sedating & the good thing is it seems to have worn off after 8 hrs.

Rispiradone. Took it. didnt feel a thing must not have taken a high enough dose. I know Olanzapine & Seroquel are suppose to be equally sedating with clozapine the only stronger one & Rispiradone being the weakest of the 4.

Theres a few other commenly presribed antipsychotics. & id like ot here ppl experiences with em. side effects, duration of effects, sedation level etc.
Click to expand...

No not all anti-psychotics either atypical or typical have much if any anti-histaminic side effects or anti-cholinergic side effects. It varies alot.

Seroquel is probably the strongest of the atypicals for causing anti-histamine like side effects hence why it is the knockout drug of the atypicals. It's the anti-histamine side effects that put you to sleep. As for what dose seroquel starts becoming a anti-psychotic I'm not sure really but 100mg's or less is not going to act as a anti-psychotic. It takes 300-400mg's a day to help my bipolar so yeah it's not that potent of a anti-psychotic.

Zyrexa (olanzapine) is not used for sleep nearly as much as seroquel. It has a long ass half life and is not as drowsy. It has anti-cholinergic side effects and that's what causes it's drowsiness. It does not make me drowsy at all though if I'm manic even at 20mg's (the top dose in a day) sometimes but it works wonders for my bipolar. Too bad i can't afford it :(

Risperdal (risperidone) has very little anti-histaminic side effects and hardly any anti-cholinergic side effects so that's why it's not a knock out atypical anti-psychotic. The only way it makes you drowsy at all is through it's very strong D2 antagonism. It is the most potent atypical anti-psychotic out there i think but a sleep aid it is not. I took it for a long time for bipolar disorder and although it helps alot sometimes i just don't like the side effects. It's the second oldest atypical the oldest being clozapine. So yeah risperdal has a fuck load of side effects and i don't know why any doctor would prescribe it for sleep cause that's just dumb. Also if any doctor gave you clozapine for a sleep disorder they should have their license taken away. That shit is dangerous and is only used when everything else fails pretty much.

I have also had a few typical anti-psychotics one being methotrimeprazine aka levomepromazine and the brand name in Canada is nozinan. I don't know what other countries you can get it in. This drug is so drowsy that it makes seroquel look like a stimulant. It is a low potency anti-psychotic only being half as potent as chlorpromazine but i find it way more drowsy at equal doses then chlorpromazine. It will knock you out for most of the day because of it's very long half life.

Chlorpromazine which is good old largactil aka thorazine is another anti-psychotic i have taken. It gets a very bad rep but i think it's not that bad at fairly low doses. I don't find it as unpleasant as risperdal or seroquel even and it doesn't feel much like a anti-psychotic to me. It is a knockout drug though totally and i don't think many docs would script thorazine for insomnus.
 
Anon54 said:
firstly id like to say i dont know how i would cope without these drugs atm. they're like stronger versions of the otc sedating antihistamines & have cured years of unessasary insomnia. Something that benzos can only barely help unless taken in insane & dangerously addictive quantities.

antipychotics arnt the nicest feeling drugs in the world but i think they get a bad wrap they dont deserve.

Does anyone know the dose of which seroquel starts working as an antipsychotic & now just a sedating anthistamine?

Are all anitpsychotics also antihistamines?


Heres some info on the ones ive tried

Olazapine makes me feel very heavy but has a cleaner tired feeling than Quetiapine. Probem being its duration is something like 16 hrs so ya feel tired half the next day.
Also makes me wanna eat alot.

Quetiapine doest make me feel as heavy & gives mild visual disortions. Even some CEV occationally in high doses. Makes my heaed spin like when i first started smoking. bit like a dissasociative. Seems more sedating & the good thing is it seems to have worn off after 8 hrs.

Rispiradone. Took it. didnt feel a thing must not have taken a high enough dose. I know Olanzapine & Seroquel are suppose to be equally sedating with clozapine the only stronger one & Rispiradone being the weakest of the 4.

Theres a few other commenly presribed antipsychotics. & id like ot here ppl experiences with em. side effects, duration of effects, sedation level etc.
Click to expand...

This article might help you:

http://thelastpsychiatrist.com/2007/07/the_most_important_article_on.html
 
Hey Anon54, how much Seroquel do you typically take for sleep/insomnia?
 
Seroquel has all its qualities at all doses, but certain qualities (for example, anti-histamine action and resulting sedation) are more apparent at certain doses. In Seroquel's case, it is a powerful anti-histamine at lower doses, and its anti-psychotic effects (action on the dopamine and serotonin systems) are still there, but they aren't powerful enough to really make any difference, at least in my experience. I have taken high doses of Seroquel and they were just as sedating as lower doses, but more disorienting and what I would consider to be "antipsychotic-like".

However, because everybody's brain and body is different, just because a certain dose will work for somebody for sedation, doesn't mean it will work for you.

Seroquel is a powerful antipsychotic drug and little to no recreational potential. There have been threads upon threads upon more threads about Seroquel and they've all, well, most of them, have come the same conclusion. Don't take antipsychotics unless you need to. There are even better drugs around for sedation. Seroquel (and other antipsychotics) are good at what they do (most of the time), but you have to remember that using them for sleep is still an off-label usage.
 
kaiba said:
Hey Anon54, how much Seroquel do you typically take for sleep/insomnia?
Click to expand...

150mg-300mg

had 300mg last night.. also had 10mg diaz (all i had left) & still woke up multiple times throughout the night :(

had very mild strange delerient effects. like i though i was standing in a different part of the room. & found it sorta had to find my way back to bed

& thx kaiba for the website
http://thelastpsychiatrist.com/2007/07/the_most_important_article_on.html

I actually already found that one yesturday

Basically,
Ive got possion of both seroquel & Zyprexa. Can get oreribed the other ones to. wanted to know ppls opions on antipychotics. which has worked the best for them.

If Zyprexa didnt last so long & keep me tired half the day it would be far saperier for seroquel with side effects.

5mg of Zyprexa= 75-100mg of seroquel if anyone is intersted in converting
 
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Anon54 said:
150mg-300mg

had 300mg last night.. also had 10mg diaz (all i had left) & still woke up multiple times throughout the night :(

had very mild strange delerient effects. like i though i was standing in a different part of the room. & found it sorta had to find my way back to bed

& thx kaiba for the website
http://thelastpsychiatrist.com/2007/07/the_most_important_article_on.html

I actually already found that one yesturday

Basically,
Ive got possion of both seroquel & Zyprexa. Can get oreribed the other ones to. wanted to know ppls opions on antipychotics. which has worked the best for them.

If Zyprexa didnt last so long & keep me tired half the day it would be far saperier for seroquel with side effects.

5mg of Zyprexa= 75-100mg of seroquel if anyone is intersted in converting
Click to expand...

The "150mg-300mg" you take at night for sleep, did the psychiatrist/doctor prescribe that amount to you?


Are you taking the regular Seroquel or the XR/extended release?


Typically, they prescribe 25/50 mg at night for sleep/insomnia.
 
kaiba said:
The "150mg-300mg" you take at night for sleep, did the psychiatrist/doctor prescribe that amount to you?


Are you taking the regular Seroquel or the XR/extended release?


Typically, they prescribe 25/50 mg at night for sleep/insomnia.
Click to expand...

yeah, I take what i want. 25mg/50mg?

not even as strong as otv phenergan
also says onn wiki that does below 150mg shouldnt be taken for more than a month which i dont understand why but that's what it says.

I was actually precribed 5mg zyprexa & they do the trick. they're equal to around 100mg seroquel.

I got ambian to play around with tonight. took 14. still dont feel a thing

on another not when i was stoned & took seroquel it was like 5 times stronger so pot must interact with em or something
 
NeighborhoodThreat said:
.........

Seroquel is a powerful antipsychotic drug..........
Click to expand...

yea and sugar is a powerful stim.
i really cant disagree with that more. that is so far down the chain on psych meds.
also i thought respirdol is a stronger relative of seroquel. dont know what op means by its the weakest. unless your going by weakest is lowest mgs. kind of shocked op didnt get much on that. ime ive noticed effects as low as 2mg i believe. may have been 3.

and op you serious about saying you dont know why they get bad rep? try asking people that take them on a daily basis or read the side effects. they arent to pleasant. especially if you get "lucky". but good to see you were truly lucky.
since stopping meds i still have tremors, twitches, zaps, full body collapses (not that common but when you have to keep aware it can happen again its a beoch), ontop of whatever affects im not aware of for sure.

for the zyprexa yea affects are lengthy at first which is common but will level out in a week or so as tolerance builds. but watch out op bc it looks like you didnt luck out on one of the big side affects there. high fast weight gain.
 
I find this to be true with Seroquel. When prescribed for sleep all doctors tell me to take 50mg so I'll take 50-100mg for this reason and get knocked the fuck out. Now just recently a doctor tried switching me from Risperidone to Seroquel XR for symptoms of anxiety caused by my bipolar and he put me on 300mg. NO sedation, in fact it made it HARDER for me to get to sleep. And anti-psychotics get a bad rep because they cause side effects that can be permanent. Seroquel made the Parkinson's type symptoms so severe that I had to go back onto the Risperidone. That and because it caused insomnia. I'm no longer fucking around with my anti-psychotic. I'll stay on the 4mg of Risperidone that I am on right now.

And to the OP, I actually heard that Risperidone is one of the most potent and older atypical anti-psychotic and Zyprexa one of the weakest. That seems to be the case for me. Zyprexa didn't work much for me yet didn't cause so much side effects other than weight gain. I used to think Seroquel was one of the most powerful due to its knock out power until now that I tried a high dose.
 
Seroquel made the Parkinson's type symptoms so severe that I had to go back onto the Risperidone.
Click to expand...

I would say that any drug with the capability of causing those types of symptoms when used as prescribed should call under the category of "powerful".
 
Here they often combine Parkinsons disease drugs with Seroquel if those kind symptoms appear. I would not still go for Seroquel as my main neuroleptic after I have been on aripiprazole even though it is expensive one (can I discuss the legit pharmacy prices here?).
 
MrRoot said:
Here they often combine Parkinsons disease drugs with Seroquel if those kind symptoms appear. I would not still go for Seroquel as my main neuroleptic after I have been on aripiprazole even though it is expensive one (can I discuss the legit pharmacy prices here?).
Click to expand...

Where did you hear this? Anti-psychotics are notorious for causing Tardive Dyskinesia, a permanent muscle problem that causes involuntary, repetitive body movements. Why would they prescribe something like that for Parkinson's disease? They would only make symptoms worse. Seroquel XR at doses around 150-300mg caused this problem for me so I went off. At 150mg it wasn't so severe but at 300mg it was unbearable.
 
^It was extremely common to prescribe benztropine or diphenhydramine (both anticholinergics used for Parkinsons) along with first generation APs to offset rigidity and other extrapyrmidial effects from the APs. Less common with 2nd generation. Sometimes they used the dopamine agonist amantadine to offset the parkinson's like effects from the APs.

2nd generation APs don't usually have extrapyrmidial side effects as severe as the 1st gen APs. Risperidone has more EPS than most of the other 2nd gen so you might find some meds to treat EPS prescribed with it once and a while.

Extrapyrmidial side effects and parkinsons are for many purposes the same thing.
 
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