It's a reversible MAOI:
The selective and reversible MAO-A inhibitors (as well as 5-HT releasers) amiflamine, alpha-ethyltryptamine, and alpha-methyltryptamine reduced markedly the ejaculatory response after both single and repeated treatments.
Rényi L. (1986). The effects of monoamine oxidase inhibitors on the ejaculatory response induced by 5-methoxy-N,N-dimethyltryptamine in the rat. British journal of pharmacology, 88(4), 827–835. doi: 10.1111/j.1476-5381.1986.tb16256.x Abstract
Patients treated with moclobemide are at lower risk for hypertensive responses to TYR; moclobemide is a RIMA [reversible inhibitor of MAO-A]
which can be displaced from MAO by higher concentrations of TYR and of NE released by TYR. This displacement restores the activity of MAO and allows it to catabolize TYR and released NE. The labeling for moclobemide carries warnings about ingesting high-TYR foods that are similar to those for irreversible MAOIs despite clear evidence in the literature that, with moclobemide doses of up to 900 mg/day, a TYR-restricted diet is not necessary (5,30).
Pharmacist Toolkit: Monoamine Oxidase Inhibitors. Rex Lott, PharmD, BCPP. Lincoln, NE: American Association of Psychiatric Pharmacists, 2022 Interaction with Tyramine-Containing Food (“Cheese” Effect)
Reversible inhibitors of MAO-A have the distinction of being easily displaced by ingested tyramine in the gut and thus do not cause the cheese reaction.
MAO Inhibitors: Risks, benefits, and lore. Wimbiscus, Molly MD; Olga Kostenk, MD; Donald Malone, MD. Dec 2010. Cleveland Clinic Journal of Medicine. 77 (12) 859-882. DOI: 10.3949/ccjm.77a.09103 Do selectivity and reversibility matter?, p. 861
https://www.poison.org/articles/making-sense-of-mao-inhibitors (See bottom of page.)
I don’t diet before ceremony. Amazonians usually don’t either. It’s just a tourist thing and everyone makes up their own version.
MapachoCura, 2024-04-25,
reddit
The dietary restrictions classically advised for patients taking oral MAO inhibitors were established to prevent hypertensive crises associated with tyramine ingestion. However, some of these restrictions were unsubstantiated,[38] and evidence from more recent studies suggests that they are unnecessarily strict[39]
[...]
Among the many foods determined to be unnecessarily restricted are avocados; bananas; beef or chicken bouillon; chocolate; fresh and mild cheeses, eg, ricotta, cottage cheese, cream cheese, processed cheese slices; fresh meat, poultry, or fish; meat gravy (fresh); monosodium glutamate; peanuts; properly stored pickled or smoked fish (eg, herring); raspberries; and yeast extracts (except Marmite).[39]
[...]
Absolute dietary restrictions include[39]:
• Aged cheeses and meats
• Banana peels
• Broad bean (fava) pods
• Spoiled meats
• Marmite
• Sauerkraut
• Soybean products
• Draft beers.
From the ‘Diet can be more lenient than in the past’ section in the article that contains the third quote above (pg. 873).
if the conclusion is anything other than tyramine and all mess that goes along with it is anything other than Hocus Pocus old science then it's meaningless collectively. I have been [tranylcypromine] for like 30 years and long ago I forgot entirely about all that tyramine and preserved sausages and stuff like that, and yet here I am, happy and healthy
pumbungler, 2024-06-03,
reddit
It's very rare to have a hypertensive crisis while on MAOIs, but the danger is there and you can get one when you least expect it. Took me two years to find out how it felt like. I ate spoiled meat and it gave me a splitting headache, felt like my head was about to explode. Before that incident i had been eating everything and paid the diet no concern at all.
I still don't care about the diet, but gourmet cheese and spoiled food should be avoided at all costs.
ChopSuey, 2014-09-22,
Re: MAOI "diet" by psychiatrists - a joke?
I don't drink beer on tap, eat artesian cheeses, or consume homemade fermented goods. I also don't eat much soy sauce. I didn't consume these foods pre MAOI anyway. Most of the information regarding food restrictions is dated and inaccurate. I've used MAOI's for about two years. After the first 2 weeks or so I don't really even think about diet restrictions.
TechnicalCatch, 2024-05-13,
reddit
Follow-up ⇩
Yup. 2.5 years on an irreversible MAOI (Nardil and Parnate separately) and I don't even think about the diet to a significant degree. Tap beer, artesian cheeses, rotten meat (ew), don't eat excess soy sauce (ew) and don't guzzle back homemade kombucha (ew). So far, it's had a minor negative impact on me maybe 1-2 times when I was offered part of a beer on tap and i declined. It would likely be fine at a good bar with kegs/lines that are maintained and used frequently but I personally don't bother. But hey, It was garbage beer anyway so...blessing in disguise i guess?
Had some loaded up pizza at dinner, and a couple of glasses of red wine today lol.
TechnicalCatch, 2024-05-26,
reddit
