Am I at risk of serotonin syndrome?

[BK38]

I'm currently on antidepressants (effexor) ,valium and respridol. Would it be a bad idea if I ate some magic truffles on Saturday with a friend? I'm also tapering Kratom.

 

[dopamimetic]

Serotonin syndrome doesn't happen with psychedelics (usually) but either very high dose or combination of a 5-HT releaser or reuptake inhibitor with a MAOI. But antidepressants like Effexor blunt the effects of psychedelics to the point of them being entirely inactive, I've been on venlafaxine and couldn't trip at all.

 

[BK38]

Serotonin syndrome doesn't happen with psychedelics (usually) but either very high dose or combination of a 5-HT releaser or reuptake inhibitor with a MAOI. But antidepressants like Effexor blunt the effects of psychedelics to the point of them being entirely inactive, I've been on venlafaxine and couldn't trip at all.

Thanks for the fast and thoughtful post. I have previously tried rolling MDMA and Zoloft (another ssri). No dice

 

[dopamimetic]

In theory should a huge dosage of the psych of choice be able to break through the tolerance induced by antidepressants because they don't antagonize 5ht2a but my experience is that there are too many side effects and the amount of chemical required puts a strain onto the budget. I went through at least 150mg, if not more, of 5-MeO-MiPT during a couple of hours and all I got was a scattered feeling brain. No euphoria, no trip.

Interestingly did LSD work though when combined with some low dosed DXM (120mg, and 200mcg of 1cP-LSD). Not a full trip but I got the colors and visions, took more than 2 hours for the effects to manifest but they eventually did. A later attempt with dosing LSD didn't work though. I wonder whether the DXM was the reason. But combining venlafaxine with DXM is considered dangerous and should be avoided if you haven't already done that combo and know therefore that it was safe for you up to a given dosage.

And yeah - empathogens get dulled too. The first attempt at 6-APB while on venlafaxine gave me some nice feelings but very threshold. A later attempt with more material didn't work at all.

 

[BK38]

Hey gang, after taking about 35 grams of mixed strengths magic truffles, I broke through despite being on 10mg diazepam and 150mg of an ssri. My friend and I had a great time tripping. It was not a very strong or crazy profound trip, but I did get to know my friend's background and some of the roots of his trouble with substances and there were lots of giggles had.