Opioids Alcohol Inducing CYP2D6 And CYP3A4 Liver Enzymes Weakening My Methadone Maintenance.

[Thomas29]

I have Read that One Beer can Induce CYP2D6 enough to Make Codeine Feel Stronger Due to Increase in Converted Morphine Via the Liver..... But then I Hear people Say One Beer Or Two is Not enough and it would take like 5-7 But I have Only Heard this about when it comes to Weakening Drugs Not just My Methadone I Am on But when Doing Oxycodone Or Any Possible Opiate And Opioid. I would just Like to KNOW WHICH ONE IS FACT AND Which Information is FALSE! I Would Prefer A Source To the Information Backing Up Behind Your Answer About this Urgent Question Of Mine Considering Tomorrow is Christmas and I would Like to Enjoy A Glass Of Wine Or Two Maybe Beer Instead I Am Not Sure. I Will Stay Away From the Alcohol Completely if it Really is even A WEAK OR SLIGHT POSSIBILITY OF BEING A CYP ENZYMES INDUCER AT ALL! It is Just Not Worth the Alcohol Consumption To Me it is Only GOOD FOR ONE THING Occasionally For Extracting Drugs Etc. Etc. And Most Importantly at Least For Me is 1 Unit Or 2 At Most For Health Safety Reasons Such As Dehydration, When Taken with Cocaine Eaten, Snorted Or Even I.V.'d Causes it to Convert Via the Liver in A Less Physically Stimulating Cocaethylene Chemical Created From Mixing Cocaine And Small Amounts Of Alcohol in the Body In Exchange For A More Mentally Euphoric High From the Cocaethylene Cocaine Conversion From Alcohol Consumption Happening Via By Inside the Liver..... It is a Spectacular Way To Reduce Cravings Since it also LASTS TWICE AS LONG HENCE IS ALSO TWICE AS CARDIOTOXIC AS Cocaine, But Main thing is I would Rather Feel AMAZING then Like My Heart Is Beating Like I Am Sprinting Vs. A Light Brisk Job Heart Beating Type Of Feeling is what Good Quality Clean Cocaine Converted Cocaethylene In the Body Feels Like To Me.


Anyways Bottom Line Can 1 Beer Or 2 TRULY FOR A FACT INDUCE CYP2D6 And CYP3A4 TO ANY DEGREE EVEN THE SLIGHTEST MINISCULE CLINICALLY UNNOTICABLE AMOUNT THAT IT DOES NOT MATTER UNLESS YOU DRINK 24 Beers Tell Me What you All Know Anyways People Please And Thank You!

 

[sekio]

alcohol is a cyp inducer when administered chronically, i dont think the effect of one beer is going to be very strong, but one beer a night would be a different story

 

[muie]

I was on methadone 205mg/day 2004-2008, again for 6 months in 2010 at 65mg/day and currently on 120mg, having gone back in April 2014 that is 5-6yrs of *daily* methadone use. Also for a good 8 months I was using methadone recreationally in 25mg and 10mg pills, which was one of my favorites in terms of overall high but without the tolerance of the MMT since I wasn't taking it daily.

I was a big drinker, at least half a 750ml bottle rum or anything 40%+ (80 proof, I think...for the American BLighters). The minimum was 2L red wine a day maybe even 3L and never more than 4L (from morning to night...late night lol)

I quickly found out I could drink a lot more with methadone than I could normally without methadone. I would drink usually 4-8hrs after my dose and going through the amounts mentioned above was no problem. I also found out I didn't get out of hand to where the police, neighbors, parents, etc would come to intervene, instead I'd feel very sedated and go to bed, usually waking up refreshed and with a minor hangover. I drank a lot more b/c of this until I decided it would be methadone or alcohol, not both! I went with methadone.

The same pharmacological mechanism of action goes for antihistamines (Benadryl, Gravol, etc), benzos (valium, lorazepam, etc) and barbiturates (phenobarbital, amobarbital, etc).

When I was on 205mg/day, one night I had saved up 120mg of phenobarbital which I took with 1.5x the methadone dose so 307mg approximately and clonazepam, expecting some extremely powerful high, instead I waited 8hrs for the buzz which never came, rather I was in minor withdrawls by the end of the 8hrs I spent watching TV. Amobarbital had the same effect on my methadone, making it much shorter lasting and also much weaker to the point an increase in dose is necessary.

I still take benzos + opiates and I love the combo but that too only contributes to the potentiation of sedation but not like Doriden which actually increased the effects of codeine drastically.

Conclusion: just b/c a drug is a powerful sedative on its own doesn't mean combining it with opioids increases the potency of the opioid rather they increase the sedation of the opioids. Doriden (gluethimide sp?) is the only one to my knowledge and isn't made anymore. Soma or carisoprodol is what I find works the best as a potentiator out of the antihistamines, benzos & barbs that's I've tried.

It has also been found (allegedly) by methadone and other opioid users that Milk Thistle works to potentiate and to increase the length of methadone and oxycodone. I personally use it and haven't noticed much though I do believe that it makes it last longer, if only slightly. St. Johns Wort along with phenobarbital are a thousand times worse than alcohol and they will remove the methadone from your body much quicker than any other drugs.