• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

RCs Alcohol and norepinephrine-dopamine reuptake inhibitors such as MDPV and Cocaine

R

ResearchSpecialist

Greenlighter
Joined
Aug 1, 2012
Messages
5
Why is it that alcohol consumption seems to make norepinephrine-dopamine reuptake inhibitor's seem so much better?

benzoylmethylecgonine by itself is good, but combined with drinking feels way better.

MDPV/A-PVP are kinda shitty by itself, yet after a couple beers it seems up there with benzoylmethylecgonine.

Is there some type of reason for this?
 
Well for cocaine at lest when it's done together with alcohol Cocaethylene is formed.

Cocaethylene appears to, in most users, produce more euphoria and possess a longer duration of action than cocaine. Some studies suggest that it may be more cardiotoxic than cocaine. Cocaethylene is more potent than cocaine at binding to the dopamine transporter, however it is less potent at binding to the serotonin transporter and norepinephrine transporter. (Source)
Click to expand...

Not sure on the others but I would think that similar chemistry could be at play.
 
Cocaethylene accounts for a minority of effects when cocaine and alcohol are consumed together. It's not actually made in a very high concentration relative to blood cocaine levels. The only other substance that recieves this "treatment" in vivo is methylphenidate - but it gets turned into an inactive isomer, preferentially, so again that doesan't contribute to the pharmacokinetics very much.

It's probably as simple as an addictive effect. Alcohol releases dopamine in the reward centers of the brain, NDRI's make it act longer. One plus one is two, as it were...

MDPV and the cathinones do not undergo transesterification like cocaine does, because they aren't esters.
 
sekio said:
Cocaethylene accounts for a minority of effects when cocaine and alcohol are consumed together. It's not actually made in a very high concentration relative to blood cocaine levels. The only other substance that recieves this "treatment" in vivo is methylphenidate - but it gets turned into an inactive isomer, preferentially, so again that doesan't contribute to the pharmacokinetics very much.

It's probably as simple as an addictive effect. Alcohol releases dopamine in the reward centers of the brain, NDRI's make it act longer. One plus one is two, as it were...

MDPV and the cathinones do not undergo transesterification like cocaine does, because they aren't esters.
Click to expand...

Ahh gotcha. sekio, I actually did know this about cocaine, yet I was wondering if something similar could apply for MDPV/apvp. Its possible that it could I guess, considering there has been only a somewhat small amount of research performed with MDPV/apvp, but its probably unlikely. Your explanation is very thorough yet makes complete sense, I appreciate the fast response! Thanks!
 
Very interesting to know sekio! I've always found myself wondering if this applied to substance other than cocaine or not.
 
You must log in or register to reply here.
Top