Alcohol and CYP enzymes induction

[jasoncrest]

Chronic use of Alcohol induces CYP enzymes. (thid is not the case with acute use)
This is big problem when someone is on Methadone: CYP enzymes induction means inreased metabolization to inactive products, -> decreased effects...

I'm a chronic alcohol drinker, and I also take Methadone daily. Are the effects of Methadone only slightly decreased, or really heavily decreased?
If I stop drinking, will I notice a big difference in the effects of Methadone?

 

[BilZ0r]

Well it's not a classical, or large scale inducer of CYP3A4, but it does do it a little bit

http://www.ncbi.nlm.nih.gov/entrez/..._uids=12824820&query_hl=2&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/entrez/..._uids=15841467&query_hl=5&itool=pubmed_docsum


But, it does do odd things to your opioid receptors
http://www.ncbi.nlm.nih.gov/entrez/..._uids=14512140&query_hl=7&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/entrez/..._uids=15882810&query_hl=9&itool=pubmed_docsum

 

[jasoncrest]

Than you very much for these links (eventhough I don't understand half of it...)

Ethanol induced CYP3A activity and content both in vitro and in vivo

So by inducing CYP3A4, Ethanol reduces the duration and the effects of Methadone (because CYP3A4 metabolize Methadone to inactive products).

Does anyone know how much alcohol does it take to reduce significantly the effects of Lethadone? (with how much alcohol (quantity and duration of use) do you really feel that Methadone is not as strong as usual?

And if you drink alcohol everyday (6 beers/day), do you notice the difference in Methadone effects?