Aeruginascin from Inocybe aeruginascens, and other triptamines

[smartshop]

Well i found this paper online and thought people on bluelight might find it interesting (if they arn't already familiar with it; it has been posted on the shroomery). I can only understand parts of it, but i thought it might be interesting to discuss what people get out of this information-wise.
There is also a nice discussion on the biosynthetic routes to psilocybin.
http://deposit.ddb.de/cgi-bin/dokserv?idn=973960833&dok_var=d1&dok_ext=pdf&filename=973960833.pdf
or
http://webdoc.sub.gwdg.de/diss/2004/jensen/

Enjoy!

 

[raybeez]

Interesting, so Aeruginascin = 4-PO-TriMmethyltryptamine? But not the same type of TMT that Shulgin looks at in Tikhal (5-MeO-TMT has the third methyl group coming off the indole ring).

I'm not great at interpreting receptor affinity numbers.. what type of effect would this compound have?

 

[smartshop]

Well, they mention something about it not crossing the blood brain barrier. So probably it doesn't have much of an effect.
This is in contrast to Jochen Gartz'es descritpion of the inocybe A. effects in his book Narrenschwamme. Maybe poeple have good experiences with the Inocye A. because they know it is rare and not possible to grow at home or in a laboratory.
I am much interested in the addition of NMT to the mushroom substrate to create a mushroom rich in beocystin. I would love to know if beocystin colors the experience of for example psylocybe samelanceata (wich happens to be the mushroom i hold in the highes regard).
Peace.

 

[yaesutom]

I'm pretty sure in the DET Gartz study it says in there that they also tried adding NMT and got plenty of 4-HO-NMT out, yeah I also would love to know the same. Unfortunately I can't do such experiments but i suuuure wish somebody would!

http://www.bluelight.ru/vb/showthread.php?t=232955

There's my old thread and a link in there to the DET study that mentions NMT, think i pulled a single page out of that jensen paper showing that suggested biosynthesis graph also.

 

[fastandbulbous]

I'm not great at interpreting receptor affinity numbers.. what type of effect would this compound have?

None, it's a quaternary amine & will not cross the blood brain barrier

 

[EN21]

F&B, I do absolutely agree!
Quats don't penetrate the BBB, except they have a specific transporter or become demethylated metabolically.
It should be relatively simple to synthesize and to try a quat like that orally. -That would be a total break through in pharmacology, if a quat could be used as an CNS agent.
To tell the truth, I also doubt any activity.

 

[smartshop]

So what do you guys think of all the funky new triptamines they synthesised and tested?