ADD Journal Club: Amphetamine induces DA efflux through a DAT channel

[5-HT2]

Because this is a forum for advanced drug discussion, I thought it appropriate to start our own journal club. Though ADD doesn't get that much traffic, BL does, and it might attract the copyright police, so we should probably limit what is posted in ADDJC to open access articles such as the following. I only posted the figures because the full text is not yet available in any format other than pdf, which is available here:

http://www.pnas.org/cgi/reprint/0407737102v1

Without further ado:

Kristopher M. Kahlig, Francesca Binda, Habibeh Khoshbouei, Randy D. Blakely, Douglas G. McMahon, Jonathan A. Javitch, and Aurelio Galli. Amphetamine induces dopamine efflux through a dopamine transporter channel. PNAS published February 22, 2005, 10.1073/pnas.0407737102

 

[5-HT2]

Figure 2

 

[5-HT2]

Figure 3

 

[5-HT2]

Figure 4

 

[Schizomanic]

I saw ADD & Amphetamine in the same tittle and instantly assumed this was going to be a discussion about attention deficit disorder

On a productive note, ADD is a great new addition to BL. Lets keep it useful, guys!

 

[BilZ0r]

Well those figures are big enough to read... ?

Man that's some dry electrophysiology. So DAT has both channel and transporter like activity... didn't we allready know that?

The rectification in the transporter (fig 3d) seems a bit odd. Doesn't it show that the current mode is only active at +40mV holding potential, or is that just me?

I'm not really down with biophysics enough to fully appriciate this paper.

 

[Synapse999]

That is a pretty technical article, i skimmed threw alot of it.
This thread could be pretty intresting, as this is a subject where they know what it does....in a way. But not exactly why.


They don't make it to clear. .at least to a novice like me. What there true point of comparing/achieving was in that. Gonna read it threw now.

There is a a few good brain spect studies and such, that show graphically and technically the differences of those effects.
Maybe a good thing to add....


I'm not sure where you would like that starting point to lead to....
But again, that is also very raw/advanced data to me...so don't see it the same.