Misc Acetaminophen Block Cannabinoid Receptors?

[muie]

Found on Wikkepedia:

"Paracetamol also modulates the endogenous cannabinoid system.[38] Paracetamol is metabolized to AM404, a compound with several actions; most important, it inhibits the uptake of the endogenous cannabinoid/vanilloid anandamide by neurons. Anandamide uptake would result in the activation of the main pain receptor (nociceptor) of the body, the TRPV1 (older name: vanilloid receptor). Furthermore, AM404 inhibits sodium channels, as do the anesthetics lidocaine and procaine.[39] Either of these actions by themselves has been shown to reduce pain, and are a possible mechanism for paracetamol.

However, it has been demonstrated that, after blocking cannabinoid receptors with synthetic antagonists, paracetamol's analgesic effects are prevented, suggesting its pain-relieving action involves activation of the endogenous cannabinoid system."

What does anybody make of this?

I also found on Wikkepedia reports that both Ibuprofen and Pseudoepheridrine block the effects of codeine.

p.s. I posted here hoping I'd get better results/anwers but by all means feel
free to move it over to the Cannabis section if you think it goes there!

 

[JoshuaV]

What that says is if you block the cannabinoid receptors with synthetics (like the JWH-018 shit, Im guessing), the tylenol doesn't work. It stands to reason, therefore, that if you smoke pot, tylenol won't work on top of it. Not the other way around.

This suggests, then, that tylenol works indirectly on the same pain-relief systems that weed does.

 

[Mr Blonde]

^ Not JWH, but antagonists; ligands that bind to the receptor without activating it, and prevent other ligands with weaker affinities from binding.

APAP does not block cannabis from having an effect.

And ibuprofen and pseudoephedrine do not block the effects of codeine.