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abuse potiential of tricyclic antidepressants

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StaySedated

StaySedated

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on many of the new store bought drug tests, tricyclic antideprssants are one of the drugs it tests for.

i have heard a few stories of their abuse by people with histories of drug abuse. i have also heard that they are sometimes used with alcohol, benzos, and some opiates(methadone being the most mentioned).

can tricyclic antidepressants be abused? if so, what kind of effects would they cause?(euphoria, reduced anxiety, sedation)

also, i've heard some have dopamine reuptake inhibitor effects but i'm not sure about those claims. i know most are serotonin and norpinephrine reuptake inhibitors, as well as having some anticholinergic effects.
 
They have a very low abuse potential. Most tricyclics act as serotonin-norepinephrine reuptake inhibitors (SNRI's), which don't really give you a "high".
 
Amitryptaline has been used recreational, I think they just knock you out, and Tricyclics are dangerous in high doses. I take Mirtazapine which isn't a tricyclic anti D, but has the same effect as them,with less side effects
 
Sweet P said:
They have a very low abuse potential. Most tricyclics act as serotonin-norepinephrine reuptake inhibitors (SNRI's), which don't really give you a "high".
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i heard they have some DRI actions, but not as strong. also heard they have sedative and anti-anxiety effects, which i would find nice. why would they be on drug tests if they aren't abusable to some extent?
 
No high at all. They just help make someone with an active mind who has trouble sleeping (like an ADD type) get into sleepy mode. Not in a fun, uncoordinated, or happy way; just a `oh, I'm getting sleepy and want to go to bed` way.

I can't imagine anyone getting a recreational use out of it. The only `off-label` use I could think of is for people wanting to extend their (or perception of) REM sleep, and dream time, and possibly for lucid dreaming potential. Even that might not work for someone who isn't already a little ADD.
 
It's a diffn class, can't think but it's not a tricyclic. It'd say it's unique in its profile, with less side effects than the tricyclics
 
I've used Mirtazipine and Trimiprimine on various occasions (my GF has them prescribed). They're both good for a come-down when you need to get to sleep (Mirtazipine being the better), but neither have much recreational potential.

edit: plus both leave me with weird "spaced out" feeling the next day, which is not unpleasant, and feels like a low dose of benzos.
 
They're not recreational in any sense in my opinion.
Yes, they provide sedation, but that's about it. And it's not really a desirable sedation either.

As said, in high doses they can bring about seizures and liver damage. The people who "abuse" them are usually those with compulsive drug abuse problems.
 
JayJohnson said:
No high at all. They just help make someone with an active mind who has trouble sleeping (like an ADD type) get into sleepy mode. Not in a fun, uncoordinated, or happy way; just a `oh, I'm getting sleepy and want to go to bed` way.

I can't imagine anyone getting a recreational use out of it. The only `off-label` use I could think of is for people wanting to extend their (or perception of) REM sleep, and dream time, and possibly for lucid dreaming potential. Even that might not work for someone who isn't already a little ADD.
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`My little Amy`, that's how I call it, DOES knock you out, not in a happy or uncoordinated way. I don't know exactly why, nor how is it pharmacology. It is always the last resort to sleep I have when benzos, nor Lyrica, nor Diphenhydramine, nor even Carisoprodol works. Amitryptiline it's almost scary for me.
 
Since the drugs have clearly defined euphoric psychological and stimulatory physiological action in cases of constant usage,on the other hand the potential for TCA abuse is well established. Any comprehensive drug screening program should include a TCA panel.
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from bigdetox.com/common drugs of abuse

hmmm... i have seen other sites that list TCAs as drugs of abuse. they are both combined with other cns depressants and by themselves. however, abuse usually occurs with people who have been taking them for awhile or by people with chronic drug seeking behavior.
 
My benzo dealer tried to sell me Remeron (Mirtazepine) and swore that it was a benzo.
I was so pissed and refused to buy them, to say the least.

Anti depressants in any form (other than maybe Tramadol, and even that's debatable) are not euphoric/recreational. And anyone who does try to "abuse" them is a complete moron with no knowledge of what good drugs are.
But StaySedated, once again you have wasted space on a subject you could have easily used the search engine/google for. Good job!
 
shoolameet said:
But StaySedated, once again you have wasted space on a subject you could have easily used the search engine/google for. Good job!
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well, go fuck youself. if you don't like the thread, DON'T FUCKIN READ IT. why don't you find a thread you like, and post all your thoughts there. i'm sure you'll find it much less of waste of everybody's time.
 
Because you post non-fucking-stop and all of your threads of wastes of space, stupid, pointless questions, and can easily be answered by using the search engine or google!

I am not even kidding, you start like 10 new threads everyday and they are always retarded. It's hard to not read your posts when you don't fucking stop posting!
In less than one month you have over 200 posts and you aren't a mod... that's ridiculous.
 
shoolameet said:
Because you post non-fucking-stop and all of your threads of wastes of space, stupid, pointless questions, and can easily be answered by using the search engine or google!

I am not even kidding, you start like 10 new threads everyday and they are always retarded. It's hard to not read your posts when you don't fucking stop posting!
In less than one month you have over 200 posts and you aren't a mod... that's ridiculous.
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its hard to stop posting stupid shit non-stop when you're on the computer on adderall :D and you have a bunch of stupid questions and weird experiences.
 
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